Reviewed, UniProtKB/Swiss-Prot Q4A041 (SDHD_STAS1)

Names and origin

Protein names

Recommended name:
    Probable D-serine dehydratase
    EC=4.3.1.18
Alternative name(s):
    D-serine deaminase
      Short name=DSD

Gene names

Name:	dsdA
Ordered Locus Names:	SSP0432

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-serine = pyruvate + NH3. HAMAP MF_01030
Cofactor	Pyridoxal phosphate By similarity.
Sequence similarities	Belongs to the serine/threonine dehydratase family. DsdA subfamily.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-amino acid metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	D-serine ammonia-lyase activity Inferred from electronic annotation. Source: EC hydro-lyase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 433	433	Probable D-serine dehydratase HAMAP MF_01030		PRO_0000291745
Amino acid modifications
	Modified residue	112	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4A041-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: FFE3D605DD45A407	FASTA	433	48,000
	10 20 30 40 50 60 MNDLATLKQD FPLIDSMQNY KPIFWENPNF RKPASLTFTL KDMEDAAQRL ERFSSYISTV 70 80 90 100 110 120 FPETENNHGL IESPLKHIPF MQNTLTNIES LPIEGKLWLK CDSHLAISGS IKARGGIYEV 130 140 150 160 170 180 LKLAETIAMQ DGDLKETADY RVLAEQKYQD LFSKYNVAVG STGNLGLSIG IMSAKLGFKV 190 200 210 220 230 240 TVHMSTDARQ WKKDLLRSRG VEVIEHQSDY QYAVAEGRKH AENDPTCHFV DDEGSSDLFL 250 260 270 280 290 300 GYTVAALRLK AQLAAENIQI DAEHPLFVYI PCGVGGGPGG VTFGLKQVFG EHVYCIFTEP 310 320 330 340 350 360 THAPCMLLGM MTQLHDKISV KDIGIDGNTD ADGLAVARPS RLVGQIMNTL LYGIQTVSDS 370 380 390 400 410 420 EMYRYLYLLS EKEDIFIEPS AASGFAGIKS AITLAKQQGI QMNQANHIVW ATGGNMVPKE 430 EMLKYVNHGK SCL

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP008934 Genomic DNA. Translation: BAE17577.1.
RefSeq	YP_300522.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3616180.
GenomeReviews	Gene locus SSP0432 in contig AP008934_GR.
KEGG	ssp:SSP0432.
NMPDR	fig|342451.4.peg.340.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4A041.
OMA	Q4A041. DHPLFVY.
Enzyme and pathway databases
BioCyc	SSAP342451:SSP0432-MON.
Family and domain databases
HAMAP	MF_01030. [Tree]
InterPro	IPR011780. D_Ser_am_lyase. IPR001926. PyrdxlP-dep_enz_bsu. IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. [Graphical view]
PANTHER	PTHR10314:SF9. D_Ser_am_lyase. 1 hit.
Pfam	PF00291. PALP. 1 hit. [Graphical view]
TIGRFAMs	TIGR02035. D_Ser_am_lyase. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SDHD_STAS1

Accession

Primary (citable) accession number: Q4A041

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)