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Protein

Polyphosphate kinase

Gene

ppk

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).UniRule annotation

Catalytic activityi

ATP + (phosphate)(n) = ADP + (phosphate)(n+1).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei439 – 4391Phosphohistidine intermediateUniRule annotation
Active sitei458 – 4581Phosphohistidine intermediateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSAP342451:GKFA-435-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyphosphate kinaseUniRule annotation (EC:2.7.4.1UniRule annotation)
Alternative name(s):
ATP-polyphosphate phosphotransferaseUniRule annotation
Polyphosphoric acid kinaseUniRule annotation
Gene namesi
Name:ppkUniRule annotation
Ordered Locus Names:SSP0433
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000006371 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 719719Polyphosphate kinasePRO_0000128660Add
BLAST

Post-translational modificationi

An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to histidine residues through a N-P bond.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi342451.SSP0433.

Structurei

3D structure databases

ProteinModelPortaliQ4A040.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini434 – 46835PLD phosphodiesteraseUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyphosphate kinase family.UniRule annotation
Contains 1 PLD phosphodiesterase domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CUU. Bacteria.
COG0855. LUCA.
HOGENOMiHOG000248948.
KOiK00937.
OMAiLSSMIHA.
OrthoDBiEOG65TRRG.

Family and domain databases

Gene3Di3.30.1840.10. 1 hit.
HAMAPiMF_00347. Polyphosphate_kinase.
InterProiIPR003414. PP_kinase.
IPR024953. PP_kinase_middle.
IPR025200. PPK_C_dom.
IPR025198. PPK_N_dom.
[Graphical view]
PfamiPF02503. PP_kinase. 1 hit.
PF13090. PP_kinase_C. 1 hit.
PF13089. PP_kinase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015589. PP_kinase. 1 hit.
SUPFAMiSSF140356. SSF140356. 1 hit.
TIGRFAMsiTIGR03705. poly_P_kin. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4A040-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRNLGDKDL NLPQYYNNRE LSWLDFNYRV LQEAQDKNNP LLEQLNFISI
60 70 80 90 100
FSSNLDEFFM VRVAGLQDQV KMGYDKPENK AQLTPKQQLV QIKLKNKEIV
110 120 130 140 150
DLQYKRYNEL IDDLKQYQVE IIKPEQLPDD LLPQLESEFK YGILPTLTPL
160 170 180 190 200
GIDAYHPFPK LNNKSLNIFV DIDTEDDINS AIVQIPSLIS RFYSFNKGDK
210 220 230 240 250
QYIILIEDII TYFINDLFSG YTVLNTFTFR ITRNADLTIH EDGAEDLLIE
260 270 280 290 300
IERFLKERKR GTAVRLEVDG RQATHEDIVW IINQLDVHDN DVYFVDGPLD
310 320 330 340 350
LTMLTDLVDH LSNKLKYLKY NKYVPQIPQS LGNHNIFDLS LKRDIFFHHP
360 370 380 390 400
YESFEPIVDF IREAAEDPNT IAIKQTLYRV SKDSPIINSL KNAAENGKQV
410 420 430 440 450
TVLVELKARF DEENNVHWAR MLEEAGCHVI YGMTHLKTHS KIALVVKRMN
460 470 480 490 500
NKLTSFIHLG TGNYNDKTAN IYTDMGLITT NAEIAEDAIN FFNYLSGYSV
510 520 530 540 550
KPEYNKLIVA PFDIRDVFLA RIDNEIKSHR ENGNGKIIMK MNSLTDKDII
560 570 580 590 600
LKLFEASCAG VKVQLIIRGI CCLKPGVPGI SENIEVVSIV GRFLEHSRIY
610 620 630 640 650
HFHNNGDDII YLSSADAMTR NMIKRVEILF PVEDKNIAKR LLDYMNLQLS
660 670 680 690 700
DNQKGRYQDE LGQYHYIENN LSPLNSQAFL MKEAMDYGQQ LKEDNTRPQV
710
MSVNERKGWF TKIRKQFRK
Length:719
Mass (Da):83,478
Last modified:September 13, 2005 - v1
Checksum:iD9EC52E02E227DA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA. Translation: BAE17578.1.
RefSeqiWP_011302400.1. NC_007350.1.

Genome annotation databases

EnsemblBacteriaiBAE17578; BAE17578; SSP0433.
GeneIDi3616181.
KEGGissp:SSP0433.
PATRICi19622355. VBIStaSap90642_0438.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA. Translation: BAE17578.1.
RefSeqiWP_011302400.1. NC_007350.1.

3D structure databases

ProteinModelPortaliQ4A040.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi342451.SSP0433.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE17578; BAE17578; SSP0433.
GeneIDi3616181.
KEGGissp:SSP0433.
PATRICi19622355. VBIStaSap90642_0438.

Phylogenomic databases

eggNOGiENOG4105CUU. Bacteria.
COG0855. LUCA.
HOGENOMiHOG000248948.
KOiK00937.
OMAiLSSMIHA.
OrthoDBiEOG65TRRG.

Enzyme and pathway databases

BioCyciSSAP342451:GKFA-435-MONOMER.

Family and domain databases

Gene3Di3.30.1840.10. 1 hit.
HAMAPiMF_00347. Polyphosphate_kinase.
InterProiIPR003414. PP_kinase.
IPR024953. PP_kinase_middle.
IPR025200. PPK_C_dom.
IPR025198. PPK_N_dom.
[Graphical view]
PfamiPF02503. PP_kinase. 1 hit.
PF13090. PP_kinase_C. 1 hit.
PF13089. PP_kinase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015589. PP_kinase. 1 hit.
SUPFAMiSSF140356. SSF140356. 1 hit.
TIGRFAMsiTIGR03705. poly_P_kin. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
    Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
    Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15305 / DSM 20229.

Entry informationi

Entry nameiPPK_STAS1
AccessioniPrimary (citable) accession number: Q4A040
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: September 13, 2005
Last modified: March 16, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.