SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q49ZN0

- FDHL_STAS1

UniProt

Q49ZN0 - FDHL_STAS1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Putative formate dehydrogenase SSP0601

Gene
SSP0601
Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Cofactori

Binds 1 2Fe-2S cluster By similarity.
Binds 4 4Fe-4S clusters By similarity.
Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi37 – 371Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi48 – 481Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi51 – 511Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi63 – 631Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi95 – 951Iron-sulfur 2 (4Fe-4S); via tele nitrogen By similarity
Metal bindingi99 – 991Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi102 – 1021Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi109 – 1091Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi147 – 1471Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi150 – 1501Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi153 – 1531Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi157 – 1571Iron-sulfur 4 (4Fe-4S) By similarity
Metal bindingi190 – 1901Iron-sulfur 4 (4Fe-4S) By similarity
Metal bindingi193 – 1931Iron-sulfur 4 (4Fe-4S) By similarity
Metal bindingi196 – 1961Iron-sulfur 4 (4Fe-4S) By similarity
Metal bindingi200 – 2001Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi264 – 2641Iron-sulfur 5 (4Fe-4S) By similarity
Metal bindingi267 – 2671Iron-sulfur 5 (4Fe-4S) By similarity
Metal bindingi271 – 2711Iron-sulfur 5 (4Fe-4S) By similarity
Metal bindingi299 – 2991Iron-sulfur 5 (4Fe-4S) By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. electron carrier activity Source: InterPro
  4. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  5. molybdenum ion binding Source: InterPro

GO - Biological processi

  1. formate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

Enzyme and pathway databases

BioCyciSSAP342451:GKFA-603-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative formate dehydrogenase SSP0601 (EC:1.2.1.2)
Gene namesi
Ordered Locus Names:SSP0601
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000006371: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 984984Putative formate dehydrogenase SSP0601PRO_0000304137Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi342451.SSP0601.

Structurei

3D structure databases

ProteinModelPortaliQ49ZN0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 79772Fe-2S ferredoxin-typeAdd
BLAST
Domaini138 – 167304Fe-4S ferredoxin-type 1Add
BLAST
Domaini181 – 211314Fe-4S ferredoxin-type 2Add
BLAST
Domaini257 – 313574Fe-4S Mo/W bis-MGD-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni252 – 984733Formate dehydrogenaseAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG3383.
HOGENOMiHOG000031440.
KOiK00123.
OMAiLVYMHPE.
OrthoDBiEOG6CVV7G.

Family and domain databases

InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view]
PfamiPF12838. Fer4_7. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
PIRSFiPIRSF036643. FDH_alpha. 1 hit.
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR01591. Fdh-alpha. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49ZN0-1 [UniParc]FASTAAdd to Basket

« Hide

MQEHLIVSLD GKDYLVEPGT NLLQFIKSQD TFVPSICYNE SLGPIQTCDT    50
CTVEIDGKME RACSTTIDRP MIVNTQNDKV QASQKEALDR ILEKHMLYCT 100
VCDYNNGDCE IHNTMDQWGL EHQTYEYKEK PYEKDYGPFY RYDPNQCILC 150
GRCVEVCQDV QVNETLTIDW ERQQPRVIWD NDTSINDSSC VGCGQCATVC 200
PCNAMLEVNM EGNAGYMTDL EPGSLAAMID LTKKAEPGYG PLFAVSDSEA 250
AMREERIEKT KTVCTYCGVG CSFDVWTKNR EVLKVQPQHE SPANKISSCV 300
KGKFGWDYVD SDERLTKPLV RKNGQFEEVE WEEALSVVAE NFNKVKGTHG 350
SDGLAFISSS KATNEESYLM QKLARQVIGT NNVDNCSRYC QAPATKGLFR 400
TVGHGGDSGS IEDLEIADMV VLIGTNTAEA HPVIASRIKR GHKLYNNTLN 450
VFDIRKHEMA ERADNFYQPK PGTDLVWLSA VTKYIIDEDL HDKAFINEWV 500
NHFDEYYKSL APYTMEFAEE TTGISKDALI DFAHQVADAK SVSIAWAMGV 550
TQQDIGSDTS TAISNLLLAT GNYRKPGSGA YPLRGHNNVQ GCSDMGSMPD 600
QFPGYQKVTD DEIRAKFERE YGETLPKQVG KDNHQMMEGI HNGEIDSLYL 650
YGEDTGIVDS NINFVQAALE KVGFLVVQDE FFTFTATYAD VVLPASPSLE 700
KTGTFTNTER RIQRLFQALE PKGDSKPDWQ IIQAVAKAMG YDWNYTHPSQ 750
IMDEIARLTP LYSGVNYDRL EGYNSLQWPV AEDGTDEPIL YLEGFNFEDK 800
KANFYPLTFD NFFKVNEEYD LHVNNGRLLE HFHEGNMTYK VPGLEYKVPN 850
AFVEVSPELA EDRGIHEGAE IKLISETGEV ELVAHVTDRV KGKEIYIPLN 900
NNAMAHGDHG AINLLTNSDV DKDTDTPSYK RTSCRMEVKT RRGKSPLNPT 950
NFRVNKQRQP QYSVRVQDKW KREDYTFPGS QVDR 984
Length:984
Mass (Da):111,049
Last modified:September 13, 2005 - v1
Checksum:i8F9B3434353CA9EF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE17746.1.
RefSeqiWP_011302546.1. NC_007350.1.
YP_300691.1. NC_007350.1.

Genome annotation databases

EnsemblBacteriaiBAE17746; BAE17746; SSP0601.
GeneIDi3616095.
KEGGissp:SSP0601.
PATRICi19622690. VBIStaSap90642_0605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE17746.1 .
RefSeqi WP_011302546.1. NC_007350.1.
YP_300691.1. NC_007350.1.

3D structure databases

ProteinModelPortali Q49ZN0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 342451.SSP0601.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE17746 ; BAE17746 ; SSP0601 .
GeneIDi 3616095.
KEGGi ssp:SSP0601.
PATRICi 19622690. VBIStaSap90642_0605.

Phylogenomic databases

eggNOGi COG3383.
HOGENOMi HOG000031440.
KOi K00123.
OMAi LVYMHPE.
OrthoDBi EOG6CVV7G.

Enzyme and pathway databases

BioCyci SSAP342451:GKFA-603-MONOMER.

Family and domain databases

InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view ]
Pfami PF12838. Fer4_7. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF036643. FDH_alpha. 1 hit.
SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view ]
SUPFAMi SSF50692. SSF50692. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR01591. Fdh-alpha. 1 hit.
PROSITEi PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
    Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
    Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15305 / DSM 20229.

Entry informationi

Entry nameiFDHL_STAS1
AccessioniPrimary (citable) accession number: Q49ZN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi