Putative formate dehydrogenase SSP0601 - Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)

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Names and origin

Protein names

Recommended name:
Putative formate dehydrogenase SSP0601
EC=1.2.1.2

Gene names

Ordered Locus Names:

SSP0601

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

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Protein attributes

Sequence length	984 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

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General annotation (Comments)

Catalytic activity

Formate + NAD⁺ = CO₂ + NADH.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 4 4Fe-4S clusters By similarity.

Molybdenum (molybdopterin) By similarity.

Sequence similarities

In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 2 4Fe-4S ferredoxin-type domains.

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Ontologies

Keywords
Domain	Repeat
Ligand	2Fe-2S 4Fe-4S Iron Iron-sulfur Metal-binding Molybdenum NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	formate metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	formate dehydrogenase complex Inferred from electronic annotation. Source: InterPro
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro formate dehydrogenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW molybdenum ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 984

984

Putative formate dehydrogenase SSP0601

PRO_0000304137

Regions

Domain

3 – 79

77

2Fe-2S ferredoxin-type

Domain

138 – 167

30

4Fe-4S ferredoxin-type 1

Domain

181 – 211

31

4Fe-4S ferredoxin-type 2

Region

252 – 984

733

Formate dehydrogenase

Sites

Metal binding

37

1

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

48

1

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

51

1

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

63

1

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

95

1

Iron-sulfur 2 (4Fe-4S); via tele nitrogen By similarity

Metal binding

99

1

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

102

1

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

109

1

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

147

1

Iron-sulfur 3 (4Fe-4S) By similarity

Metal binding

150

1

Iron-sulfur 3 (4Fe-4S) By similarity

Metal binding

153

1

Iron-sulfur 3 (4Fe-4S) By similarity

Metal binding

157

1

Iron-sulfur 4 (4Fe-4S) By similarity

Metal binding

190

1

Iron-sulfur 4 (4Fe-4S) By similarity

Metal binding

193

1

Iron-sulfur 4 (4Fe-4S) By similarity

Metal binding

196

1

Iron-sulfur 4 (4Fe-4S) By similarity

Metal binding

200

1

Iron-sulfur 3 (4Fe-4S) By similarity

Metal binding

264

1

Iron-sulfur 5 (4Fe-4S) By similarity

Metal binding

267

1

Iron-sulfur 5 (4Fe-4S) By similarity

Metal binding

271

1

Iron-sulfur 5 (4Fe-4S) By similarity

Metal binding

299

1

Iron-sulfur 5 (4Fe-4S) By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

Q49ZN0-1 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 8F9B3434353CA9EF
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FASTA

984

111,049

        10         20         30         40         50         60 
MQEHLIVSLD GKDYLVEPGT NLLQFIKSQD TFVPSICYNE SLGPIQTCDT CTVEIDGKME 

        70         80         90        100        110        120 
RACSTTIDRP MIVNTQNDKV QASQKEALDR ILEKHMLYCT VCDYNNGDCE IHNTMDQWGL 

       130        140        150        160        170        180 
EHQTYEYKEK PYEKDYGPFY RYDPNQCILC GRCVEVCQDV QVNETLTIDW ERQQPRVIWD 

       190        200        210        220        230        240 
NDTSINDSSC VGCGQCATVC PCNAMLEVNM EGNAGYMTDL EPGSLAAMID LTKKAEPGYG 

       250        260        270        280        290        300 
PLFAVSDSEA AMREERIEKT KTVCTYCGVG CSFDVWTKNR EVLKVQPQHE SPANKISSCV 

       310        320        330        340        350        360 
KGKFGWDYVD SDERLTKPLV RKNGQFEEVE WEEALSVVAE NFNKVKGTHG SDGLAFISSS 

       370        380        390        400        410        420 
KATNEESYLM QKLARQVIGT NNVDNCSRYC QAPATKGLFR TVGHGGDSGS IEDLEIADMV 

       430        440        450        460        470        480 
VLIGTNTAEA HPVIASRIKR GHKLYNNTLN VFDIRKHEMA ERADNFYQPK PGTDLVWLSA 

       490        500        510        520        530        540 
VTKYIIDEDL HDKAFINEWV NHFDEYYKSL APYTMEFAEE TTGISKDALI DFAHQVADAK 

       550        560        570        580        590        600 
SVSIAWAMGV TQQDIGSDTS TAISNLLLAT GNYRKPGSGA YPLRGHNNVQ GCSDMGSMPD 

       610        620        630        640        650        660 
QFPGYQKVTD DEIRAKFERE YGETLPKQVG KDNHQMMEGI HNGEIDSLYL YGEDTGIVDS 

       670        680        690        700        710        720 
NINFVQAALE KVGFLVVQDE FFTFTATYAD VVLPASPSLE KTGTFTNTER RIQRLFQALE 

       730        740        750        760        770        780 
PKGDSKPDWQ IIQAVAKAMG YDWNYTHPSQ IMDEIARLTP LYSGVNYDRL EGYNSLQWPV 

       790        800        810        820        830        840 
AEDGTDEPIL YLEGFNFEDK KANFYPLTFD NFFKVNEEYD LHVNNGRLLE HFHEGNMTYK 

       850        860        870        880        890        900 
VPGLEYKVPN AFVEVSPELA EDRGIHEGAE IKLISETGEV ELVAHVTDRV KGKEIYIPLN 

       910        920        930        940        950        960 
NNAMAHGDHG AINLLTNSDV DKDTDTPSYK RTSCRMEVKT RRGKSPLNPT NFRVNKQRQP 

       970        980 
QYSVRVQDKW KREDYTFPGS QVDR

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References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases
	AP008934 Genomic DNA. Translation: BAE17746.1.
RefSeq	YP_300691.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3616095.
GenomeReviews	Gene locus SSP0601 in contig AP008934_GR.
KEGG	ssp:SSP0601.
NMPDR	fig\|342451.4.peg.780.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q49ZN0.
OMA	Q49ZN0. NETISID.
Enzyme and pathway databases
BioCyc	SSAP342451:SSP0601-MON.
Family and domain databases
InterPro	IPR017896. 4Fe4S_Fe-S-bd. IPR001450. 4Fe4S_Fe_S_bd_subgr. IPR017900. 4Fe4S_Fe_S_CS. IPR009010. Asp_de-COase-like_fold. IPR001041. Ferredoxin. IPR006478. Formate_DH_asu. IPR006656. Mopterin_OxRdtase. IPR006963. Mopterin_OxRdtase_Fe4S4. IPR006655. Mopterin_OxRdtase_prok_CS. IPR006657. MPT_dinuc_bd. IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd. [Graphical view]
Gene3D	G3DSA:2.40.40.20. Asp_decarboxylase-like_fold. 1 hit.
Pfam	PF00111. Fer2. 1 hit. PF00037. Fer4. 2 hits. PF04879. Molybdop_Fe4S4. 1 hit. PF00384. Molybdopterin. 1 hit. PF01568. Molydop_binding. 1 hit. PF10588. NADH-G_4Fe-4S_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR01591. Fdh-alpha. 1 hit.
PROSITE	PS51085. 2FE2S_FER_2. 1 hit. PS00198. 4FE4S_FER_1. 1 hit. PS51379. 4FE4S_FER_2. 2 hits. PS00551. MOLYBDOPTERIN_PROK_1. 1 hit. PS00490. MOLYBDOPTERIN_PROK_2. False negative. PS00932. MOLYBDOPTERIN_PROK_3. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

FDHL_STAS1

Accession

Primary (citable) accession number: Q49ZN0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents