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Protein

Putative formate dehydrogenase SSP0601

Gene

SSP0601

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi37Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi48Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi51Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi63Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi95Iron-sulfur 2 (4Fe-4S); via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi99Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi102Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi109Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi147Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi150Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi153Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi157Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi190Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi193Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi196Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi200Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi264Iron-sulfur 5 (4Fe-4S)By similarity1
Metal bindingi267Iron-sulfur 5 (4Fe-4S)By similarity1
Metal bindingi271Iron-sulfur 5 (4Fe-4S)By similarity1
Metal bindingi299Iron-sulfur 5 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Ligand2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

Enzyme and pathway databases

BioCyciSSAP342451:G1G2H-581-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative formate dehydrogenase SSP0601 (EC:1.17.1.9)
Gene namesi
Ordered Locus Names:SSP0601
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000006371 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003041371 – 984Putative formate dehydrogenase SSP0601Add BLAST984

Proteomic databases

PRIDEiQ49ZN0

Interactioni

Protein-protein interaction databases

STRINGi342451.SSP0601

Structurei

3D structure databases

ProteinModelPortaliQ49ZN0
SMRiQ49ZN0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 792Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST77
Domaini79 – 1194Fe-4S His(Cys)3-ligated-typePROSITE-ProRule annotationAdd BLAST41
Domaini138 – 1674Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST30
Domaini181 – 2114Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST31
Domaini257 – 3134Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni252 – 984Formate dehydrogenaseAdd BLAST733

Sequence similaritiesi

In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108HIZ Bacteria
COG3383 LUCA
HOGENOMiHOG000031440
KOiK00123
OMAiTNTAECH
OrthoDBiPOG091H037M

Family and domain databases

CDDicd00207 fer2, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR009010 Asp_de-COase-like_dom_sf
IPR006478 Formate_DH_asu
IPR006657 MoPterin_dinucl-bd_dom
IPR006656 Mopterin_OxRdtase
IPR006963 Mopterin_OxRdtase_4Fe-4S_dom
IPR006655 Mopterin_OxRdtase_prok_CS
IPR027467 MopterinOxRdtase_cofactor_BS
IPR019574 NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd
PfamiView protein in Pfam
PF12838 Fer4_7, 1 hit
PF04879 Molybdop_Fe4S4, 1 hit
PF00384 Molybdopterin, 1 hit
PF01568 Molydop_binding, 1 hit
PF10588 NADH-G_4Fe-4S_3, 1 hit
SMARTiView protein in SMART
SM00926 Molybdop_Fe4S4, 1 hit
SM00929 NADH-G_4Fe-4S_3, 1 hit
SUPFAMiSSF50692 SSF50692, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR01591 Fdh-alpha, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits
PS51839 4FE4S_HC3, 1 hit
PS51669 4FE4S_MOW_BIS_MGD, 1 hit
PS00551 MOLYBDOPTERIN_PROK_1, 1 hit
PS00932 MOLYBDOPTERIN_PROK_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q49ZN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEHLIVSLD GKDYLVEPGT NLLQFIKSQD TFVPSICYNE SLGPIQTCDT
60 70 80 90 100
CTVEIDGKME RACSTTIDRP MIVNTQNDKV QASQKEALDR ILEKHMLYCT
110 120 130 140 150
VCDYNNGDCE IHNTMDQWGL EHQTYEYKEK PYEKDYGPFY RYDPNQCILC
160 170 180 190 200
GRCVEVCQDV QVNETLTIDW ERQQPRVIWD NDTSINDSSC VGCGQCATVC
210 220 230 240 250
PCNAMLEVNM EGNAGYMTDL EPGSLAAMID LTKKAEPGYG PLFAVSDSEA
260 270 280 290 300
AMREERIEKT KTVCTYCGVG CSFDVWTKNR EVLKVQPQHE SPANKISSCV
310 320 330 340 350
KGKFGWDYVD SDERLTKPLV RKNGQFEEVE WEEALSVVAE NFNKVKGTHG
360 370 380 390 400
SDGLAFISSS KATNEESYLM QKLARQVIGT NNVDNCSRYC QAPATKGLFR
410 420 430 440 450
TVGHGGDSGS IEDLEIADMV VLIGTNTAEA HPVIASRIKR GHKLYNNTLN
460 470 480 490 500
VFDIRKHEMA ERADNFYQPK PGTDLVWLSA VTKYIIDEDL HDKAFINEWV
510 520 530 540 550
NHFDEYYKSL APYTMEFAEE TTGISKDALI DFAHQVADAK SVSIAWAMGV
560 570 580 590 600
TQQDIGSDTS TAISNLLLAT GNYRKPGSGA YPLRGHNNVQ GCSDMGSMPD
610 620 630 640 650
QFPGYQKVTD DEIRAKFERE YGETLPKQVG KDNHQMMEGI HNGEIDSLYL
660 670 680 690 700
YGEDTGIVDS NINFVQAALE KVGFLVVQDE FFTFTATYAD VVLPASPSLE
710 720 730 740 750
KTGTFTNTER RIQRLFQALE PKGDSKPDWQ IIQAVAKAMG YDWNYTHPSQ
760 770 780 790 800
IMDEIARLTP LYSGVNYDRL EGYNSLQWPV AEDGTDEPIL YLEGFNFEDK
810 820 830 840 850
KANFYPLTFD NFFKVNEEYD LHVNNGRLLE HFHEGNMTYK VPGLEYKVPN
860 870 880 890 900
AFVEVSPELA EDRGIHEGAE IKLISETGEV ELVAHVTDRV KGKEIYIPLN
910 920 930 940 950
NNAMAHGDHG AINLLTNSDV DKDTDTPSYK RTSCRMEVKT RRGKSPLNPT
960 970 980
NFRVNKQRQP QYSVRVQDKW KREDYTFPGS QVDR
Length:984
Mass (Da):111,049
Last modified:September 13, 2005 - v1
Checksum:i8F9B3434353CA9EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA Translation: BAE17746.1
RefSeqiWP_011302546.1, NZ_MTGA01000036.1

Genome annotation databases

EnsemblBacteriaiBAE17746; BAE17746; SSP0601
GeneIDi3616095
KEGGissp:SSP0601
PATRICifig|342451.11.peg.605

Similar proteinsi

Entry informationi

Entry nameiFDHL_STAS1
AccessioniPrimary (citable) accession number: Q49ZN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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