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Protein

Putative formate dehydrogenase SSP0601

Gene

SSP0601

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi37 – 371Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi48 – 481Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi51 – 511Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi63 – 631Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi95 – 951Iron-sulfur 2 (4Fe-4S); via tele nitrogenBy similarity
Metal bindingi99 – 991Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi102 – 1021Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi109 – 1091Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi147 – 1471Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi150 – 1501Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi153 – 1531Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi157 – 1571Iron-sulfur 4 (4Fe-4S)By similarity
Metal bindingi190 – 1901Iron-sulfur 4 (4Fe-4S)By similarity
Metal bindingi193 – 1931Iron-sulfur 4 (4Fe-4S)By similarity
Metal bindingi196 – 1961Iron-sulfur 4 (4Fe-4S)By similarity
Metal bindingi200 – 2001Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi264 – 2641Iron-sulfur 5 (4Fe-4S)By similarity
Metal bindingi267 – 2671Iron-sulfur 5 (4Fe-4S)By similarity
Metal bindingi271 – 2711Iron-sulfur 5 (4Fe-4S)By similarity
Metal bindingi299 – 2991Iron-sulfur 5 (4Fe-4S)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

Enzyme and pathway databases

BioCyciSSAP342451:GKFA-603-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative formate dehydrogenase SSP0601 (EC:1.2.1.2)
Gene namesi
Ordered Locus Names:SSP0601
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000006371 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 984984Putative formate dehydrogenase SSP0601PRO_0000304137Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi342451.SSP0601.

Structurei

3D structure databases

ProteinModelPortaliQ49ZN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 79772Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST
Domaini138 – 167304Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini181 – 211314Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini257 – 313574Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni252 – 984733Formate dehydrogenaseAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.Curated
Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation
Contains 1 4Fe-4S Mo/W bis-MGD-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG3383.
HOGENOMiHOG000031440.
KOiK00123.
OMAiWGVTLQP.
OrthoDBiEOG6CVV7G.

Family and domain databases

InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view]
PfamiPF12838. Fer4_7. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
PIRSFiPIRSF036643. FDH_alpha. 1 hit.
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR01591. Fdh-alpha. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49ZN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEHLIVSLD GKDYLVEPGT NLLQFIKSQD TFVPSICYNE SLGPIQTCDT
60 70 80 90 100
CTVEIDGKME RACSTTIDRP MIVNTQNDKV QASQKEALDR ILEKHMLYCT
110 120 130 140 150
VCDYNNGDCE IHNTMDQWGL EHQTYEYKEK PYEKDYGPFY RYDPNQCILC
160 170 180 190 200
GRCVEVCQDV QVNETLTIDW ERQQPRVIWD NDTSINDSSC VGCGQCATVC
210 220 230 240 250
PCNAMLEVNM EGNAGYMTDL EPGSLAAMID LTKKAEPGYG PLFAVSDSEA
260 270 280 290 300
AMREERIEKT KTVCTYCGVG CSFDVWTKNR EVLKVQPQHE SPANKISSCV
310 320 330 340 350
KGKFGWDYVD SDERLTKPLV RKNGQFEEVE WEEALSVVAE NFNKVKGTHG
360 370 380 390 400
SDGLAFISSS KATNEESYLM QKLARQVIGT NNVDNCSRYC QAPATKGLFR
410 420 430 440 450
TVGHGGDSGS IEDLEIADMV VLIGTNTAEA HPVIASRIKR GHKLYNNTLN
460 470 480 490 500
VFDIRKHEMA ERADNFYQPK PGTDLVWLSA VTKYIIDEDL HDKAFINEWV
510 520 530 540 550
NHFDEYYKSL APYTMEFAEE TTGISKDALI DFAHQVADAK SVSIAWAMGV
560 570 580 590 600
TQQDIGSDTS TAISNLLLAT GNYRKPGSGA YPLRGHNNVQ GCSDMGSMPD
610 620 630 640 650
QFPGYQKVTD DEIRAKFERE YGETLPKQVG KDNHQMMEGI HNGEIDSLYL
660 670 680 690 700
YGEDTGIVDS NINFVQAALE KVGFLVVQDE FFTFTATYAD VVLPASPSLE
710 720 730 740 750
KTGTFTNTER RIQRLFQALE PKGDSKPDWQ IIQAVAKAMG YDWNYTHPSQ
760 770 780 790 800
IMDEIARLTP LYSGVNYDRL EGYNSLQWPV AEDGTDEPIL YLEGFNFEDK
810 820 830 840 850
KANFYPLTFD NFFKVNEEYD LHVNNGRLLE HFHEGNMTYK VPGLEYKVPN
860 870 880 890 900
AFVEVSPELA EDRGIHEGAE IKLISETGEV ELVAHVTDRV KGKEIYIPLN
910 920 930 940 950
NNAMAHGDHG AINLLTNSDV DKDTDTPSYK RTSCRMEVKT RRGKSPLNPT
960 970 980
NFRVNKQRQP QYSVRVQDKW KREDYTFPGS QVDR
Length:984
Mass (Da):111,049
Last modified:September 13, 2005 - v1
Checksum:i8F9B3434353CA9EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA. Translation: BAE17746.1.
RefSeqiWP_011302546.1. NC_007350.1.

Genome annotation databases

EnsemblBacteriaiBAE17746; BAE17746; SSP0601.
GeneIDi23780903.
KEGGissp:SSP0601.
PATRICi19622690. VBIStaSap90642_0605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA. Translation: BAE17746.1.
RefSeqiWP_011302546.1. NC_007350.1.

3D structure databases

ProteinModelPortaliQ49ZN0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi342451.SSP0601.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE17746; BAE17746; SSP0601.
GeneIDi23780903.
KEGGissp:SSP0601.
PATRICi19622690. VBIStaSap90642_0605.

Phylogenomic databases

eggNOGiCOG3383.
HOGENOMiHOG000031440.
KOiK00123.
OMAiWGVTLQP.
OrthoDBiEOG6CVV7G.

Enzyme and pathway databases

BioCyciSSAP342451:GKFA-603-MONOMER.

Family and domain databases

InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view]
PfamiPF12838. Fer4_7. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
PIRSFiPIRSF036643. FDH_alpha. 1 hit.
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR01591. Fdh-alpha. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
    Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
    Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15305 / DSM 20229.

Entry informationi

Entry nameiFDHL_STAS1
AccessioniPrimary (citable) accession number: Q49ZN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 13, 2005
Last modified: July 22, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.