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Q49ZN0

- FDHL_STAS1

UniProt

Q49ZN0 - FDHL_STAS1

Protein

Putative formate dehydrogenase SSP0601

Gene

SSP0601

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Formate + NAD+ = CO2 + NADH.

    Cofactori

    Binds 1 2Fe-2S cluster.By similarity
    Binds 4 4Fe-4S clusters.By similarity
    Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi37 – 371Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi48 – 481Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi51 – 511Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi63 – 631Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi95 – 951Iron-sulfur 2 (4Fe-4S); via tele nitrogenBy similarity
    Metal bindingi99 – 991Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi102 – 1021Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi109 – 1091Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi147 – 1471Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi150 – 1501Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi153 – 1531Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi157 – 1571Iron-sulfur 4 (4Fe-4S)By similarity
    Metal bindingi190 – 1901Iron-sulfur 4 (4Fe-4S)By similarity
    Metal bindingi193 – 1931Iron-sulfur 4 (4Fe-4S)By similarity
    Metal bindingi196 – 1961Iron-sulfur 4 (4Fe-4S)By similarity
    Metal bindingi200 – 2001Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi264 – 2641Iron-sulfur 5 (4Fe-4S)By similarity
    Metal bindingi267 – 2671Iron-sulfur 5 (4Fe-4S)By similarity
    Metal bindingi271 – 2711Iron-sulfur 5 (4Fe-4S)By similarity
    Metal bindingi299 – 2991Iron-sulfur 5 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    3. electron carrier activity Source: InterPro
    4. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
    5. molybdenum ion binding Source: InterPro

    GO - Biological processi

    1. formate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

    Enzyme and pathway databases

    BioCyciSSAP342451:GKFA-603-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative formate dehydrogenase SSP0601 (EC:1.2.1.2)
    Gene namesi
    Ordered Locus Names:SSP0601
    OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
    Taxonomic identifieri342451 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000006371: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 984984Putative formate dehydrogenase SSP0601PRO_0000304137Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi342451.SSP0601.

    Structurei

    3D structure databases

    ProteinModelPortaliQ49ZN0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 79772Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini138 – 167304Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini181 – 211314Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini257 – 313574Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni252 – 984733Formate dehydrogenaseAdd
    BLAST

    Sequence similaritiesi

    In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.Curated
    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation
    Contains 1 4Fe-4S Mo/W bis-MGD-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG3383.
    HOGENOMiHOG000031440.
    KOiK00123.
    OMAiLVYMHPE.
    OrthoDBiEOG6CVV7G.

    Family and domain databases

    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR001450. 4Fe4S-bd_dom.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR009010. Asp_de-COase-like_dom.
    IPR006478. Formate_DH_asu.
    IPR006657. MoPterin_dinucl-bd_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR006655. Mopterin_OxRdtase_prok_CS.
    IPR027467. MopterinOxRdtase_cofactor_BS.
    IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
    [Graphical view]
    PfamiPF12838. Fer4_7. 1 hit.
    PF04879. Molybdop_Fe4S4. 1 hit.
    PF00384. Molybdopterin. 1 hit.
    PF01568. Molydop_binding. 1 hit.
    PF10588. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036643. FDH_alpha. 1 hit.
    SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
    SM00929. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50692. SSF50692. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR01591. Fdh-alpha. 1 hit.
    PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 2 hits.
    PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
    PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q49ZN0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQEHLIVSLD GKDYLVEPGT NLLQFIKSQD TFVPSICYNE SLGPIQTCDT    50
    CTVEIDGKME RACSTTIDRP MIVNTQNDKV QASQKEALDR ILEKHMLYCT 100
    VCDYNNGDCE IHNTMDQWGL EHQTYEYKEK PYEKDYGPFY RYDPNQCILC 150
    GRCVEVCQDV QVNETLTIDW ERQQPRVIWD NDTSINDSSC VGCGQCATVC 200
    PCNAMLEVNM EGNAGYMTDL EPGSLAAMID LTKKAEPGYG PLFAVSDSEA 250
    AMREERIEKT KTVCTYCGVG CSFDVWTKNR EVLKVQPQHE SPANKISSCV 300
    KGKFGWDYVD SDERLTKPLV RKNGQFEEVE WEEALSVVAE NFNKVKGTHG 350
    SDGLAFISSS KATNEESYLM QKLARQVIGT NNVDNCSRYC QAPATKGLFR 400
    TVGHGGDSGS IEDLEIADMV VLIGTNTAEA HPVIASRIKR GHKLYNNTLN 450
    VFDIRKHEMA ERADNFYQPK PGTDLVWLSA VTKYIIDEDL HDKAFINEWV 500
    NHFDEYYKSL APYTMEFAEE TTGISKDALI DFAHQVADAK SVSIAWAMGV 550
    TQQDIGSDTS TAISNLLLAT GNYRKPGSGA YPLRGHNNVQ GCSDMGSMPD 600
    QFPGYQKVTD DEIRAKFERE YGETLPKQVG KDNHQMMEGI HNGEIDSLYL 650
    YGEDTGIVDS NINFVQAALE KVGFLVVQDE FFTFTATYAD VVLPASPSLE 700
    KTGTFTNTER RIQRLFQALE PKGDSKPDWQ IIQAVAKAMG YDWNYTHPSQ 750
    IMDEIARLTP LYSGVNYDRL EGYNSLQWPV AEDGTDEPIL YLEGFNFEDK 800
    KANFYPLTFD NFFKVNEEYD LHVNNGRLLE HFHEGNMTYK VPGLEYKVPN 850
    AFVEVSPELA EDRGIHEGAE IKLISETGEV ELVAHVTDRV KGKEIYIPLN 900
    NNAMAHGDHG AINLLTNSDV DKDTDTPSYK RTSCRMEVKT RRGKSPLNPT 950
    NFRVNKQRQP QYSVRVQDKW KREDYTFPGS QVDR 984
    Length:984
    Mass (Da):111,049
    Last modified:September 13, 2005 - v1
    Checksum:i8F9B3434353CA9EF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008934 Genomic DNA. Translation: BAE17746.1.
    RefSeqiWP_011302546.1. NC_007350.1.
    YP_300691.1. NC_007350.1.

    Genome annotation databases

    EnsemblBacteriaiBAE17746; BAE17746; SSP0601.
    GeneIDi3616095.
    KEGGissp:SSP0601.
    PATRICi19622690. VBIStaSap90642_0605.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008934 Genomic DNA. Translation: BAE17746.1 .
    RefSeqi WP_011302546.1. NC_007350.1.
    YP_300691.1. NC_007350.1.

    3D structure databases

    ProteinModelPortali Q49ZN0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 342451.SSP0601.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE17746 ; BAE17746 ; SSP0601 .
    GeneIDi 3616095.
    KEGGi ssp:SSP0601.
    PATRICi 19622690. VBIStaSap90642_0605.

    Phylogenomic databases

    eggNOGi COG3383.
    HOGENOMi HOG000031440.
    KOi K00123.
    OMAi LVYMHPE.
    OrthoDBi EOG6CVV7G.

    Enzyme and pathway databases

    BioCyci SSAP342451:GKFA-603-MONOMER.

    Family and domain databases

    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR001450. 4Fe4S-bd_dom.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR009010. Asp_de-COase-like_dom.
    IPR006478. Formate_DH_asu.
    IPR006657. MoPterin_dinucl-bd_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR006655. Mopterin_OxRdtase_prok_CS.
    IPR027467. MopterinOxRdtase_cofactor_BS.
    IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
    [Graphical view ]
    Pfami PF12838. Fer4_7. 1 hit.
    PF04879. Molybdop_Fe4S4. 1 hit.
    PF00384. Molybdopterin. 1 hit.
    PF01568. Molydop_binding. 1 hit.
    PF10588. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036643. FDH_alpha. 1 hit.
    SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
    SM00929. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50692. SSF50692. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR01591. Fdh-alpha. 1 hit.
    PROSITEi PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 2 hits.
    PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
    PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
      Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
      Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15305 / DSM 20229.

    Entry informationi

    Entry nameiFDHL_STAS1
    AccessioniPrimary (citable) accession number: Q49ZN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3