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Q49ZM5 (Y606_STAS1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative 2-hydroxyacid dehydrogenase SSP0606
EC=1.1.1.-
Gene names
Ordered Locus Names:SSP0606
OrganismStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]
Taxonomic identifier342451 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Putative 2-hydroxyacid dehydrogenase SSP0606
PRO_0000312192

Regions

Nucleotide binding156 – 1572NAD By similarity
Nucleotide binding235 – 2373NAD By similarity
Nucleotide binding284 – 2874NAD By similarity

Sites

Active site2371 By similarity
Active site2661 By similarity
Active site2841Proton donor By similarity
Binding site2611NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q49ZM5 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 938DCFD425F8DD03

FASTA31834,974
        10         20         30         40         50         60 
MVKVYIAGPI PEVGLNLLKD QGFEVDMYEG TGIIDKETLK QGVKDADALI SLLSTSVDKE 

        70         80         90        100        110        120 
VIDAANNLKI ITNYGAGFNN VDIDYARQQN IDVTNTPKAS TNSTAELTFA LVLAVARRIP 

       130        140        150        160        170        180 
EGDKLCRTTG FDGWAPLFFR GREVSGKTIG IIGLGEIGSA VARRAKAFDM NILYTGPHQK 

       190        200        210        220        230        240 
VDKEREIGAK YVDLETLLKN ADFVTINAAY NPSLHHQIDK AQFEMMKPTS YLINASRGPI 

       250        260        270        280        290        300 
VHEKALVQAL KDKEIEGAAL DVFEFEPEIN DELKTLDNVV ITPHIGNATF ESRDMMSKIV 

       310 
ANDTISKLNN DQPKFIVN

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References

[1]"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15305 / DSM 20229.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008934 Genomic DNA. Translation: BAE17751.1.
RefSeqYP_300696.1. NC_007350.1.

3D structure databases

HSSPHSSP built from PDB template 2DBZ based on UniProtKB O58320.
ProteinModelPortalQ49ZM5.
ModBaseSearch...

Protein-protein interaction databases

STRING342451.SSP0606.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE17751; BAE17751; SSP0606.
GeneID3616100.
KEGGssp:SSP0606.
PATRIC19622700. VBIStaSap90642_0610.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1052.
HOGENOMHOG000136700.
OMADKEREIG.
ProtClustDBCLSK885881.

Family and domain databases

Gene3D3.40.50.720. 2 hits.
InterProIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_2_OHA_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEPS00065. D_2_HYDROXYACID_DH_1. False negative.
PS00670. D_2_HYDROXYACID_DH_2. False negative.
PS00671. D_2_HYDROXYACID_DH_3. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameY606_STAS1
AccessionPrimary (citable) accession number: Q49ZM5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: September 13, 2005
Last modified: May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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