ID   GAL1_STAS1              Reviewed;         386 AA.
AC   Q49ZK2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Galactokinase;
DE            EC=2.7.1.6;
DE   AltName: Full=Galactose kinase;
GN   Name=galK; OrderedLocusNames=SSP0629;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 /
OS   DSM 20229).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K.,
RA   Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S.,
RA   Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- CATALYTIC ACTIVITY: ATP + D-galactose = ADP + alpha-D-galactose 1-
CC       phosphate.
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. GalK subfamily.
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DR   EMBL; AP008934; BAE17774.1; -; Genomic_DNA.
DR   RefSeq; YP_300719.1; -.
DR   GeneID; 3616025; -.
DR   GenomeReviews; AP008934_GR; SSP0629.
DR   KEGG; ssp:SSP0629; -.
DR   NMPDR; fig|342451.4.peg.808; -.
DR   HOGENOM; Q49ZK2; -.
DR   OMA; Q49ZK2; ISENERT.
DR   BioCyc; SSAP342451:SSP0629-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004335; F:galactokinase activity; IEA:HAMAP.
DR   GO; GO:0046835; P:carbohydrate phosphorylation; IEA:InterPro.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:HAMAP.
DR   HAMAP; MF_00246; -; 1.
DR   InterPro; IPR000705; Galactokinase.
DR   InterPro; IPR019741; Galactokinase_CS.
DR   InterPro; IPR019539; GalKase_gal_bd.
DR   InterPro; IPR006204; GHMP_kinase.
DR   InterPro; IPR013750; GHMP_kinase_C.
DR   InterPro; IPR006203; GHMP_knse_ATP_bd_CS.
DR   InterPro; IPR006206; Mev_galkinase.
DR   InterPro; IPR014721; Ribosomal_S5_D2-type_fold.
DR   Gene3D; G3DSA:3.30.230.10; Ribosomal_S5_D2-type_fold; 1.
DR   Pfam; PF10509; GalKase_gal_bdg; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF000530; Galactokinase; 1.
DR   PRINTS; PR00473; GALCTOKINASE.
DR   PRINTS; PR00959; MEVGALKINASE.
DR   TIGRFAMs; TIGR00131; gal_kin; 1.
DR   PROSITE; PS00106; GALACTOKINASE; 1.
DR   PROSITE; PS00627; GHMP_KINASES_ATP; FALSE_NEG.
PE   3: Inferred from homology;
KW   ATP-binding; Carbohydrate metabolism; Complete proteome; Cytoplasm;
KW   Galactose metabolism; Kinase; Nucleotide-binding; Transferase.
FT   CHAIN         1    386       Galactokinase.
FT                                /FTId=PRO_1000005765.
FT   NP_BIND     121    131       ATP (Potential).
SQ   SEQUENCE   386 AA;  43131 MW;  43B27DBA4366952C CRC64;
     MLQEMHKKFE SLFDVKADVR AFAPGRINLI GEHTDYNGGY VFPAAIELGT YGLASKRTDR
     IIQLYSNNFE DTGIVSFTLD ELEFNEQHDW ANYPKGVVKY LKEEFNDINQ GFNILVEGNI
     PNGASLSSSA SIELLTGWLI KQLFNLHLER LQLIKLGQVV ENKFMGVNSG IMDQFIIGMG
     KAEHAILLDT ATLDFDYVPA KFGDYVISIM NTNKRRSLTE SKYNERRSEC ENALSQLQQQ
     LEITSLGELS LAQFEKYQSL ITDEVVCRRA KHAISENERT KLAHKALADN NFEQFGQLLN
     ASHKSLKEDY EVTGIELDTL AETAQQVEGV LGARMTGAGF AGCAIALVDK NSIQKLEDEV
     SKAYIDKIGY APSFYHVGIS DGVKAL
//