Q49ZK2 (GAL1_STAS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactokinase
EC=2.7.1.6

Alternative name(s):
Galactose kinase

Gene names

Name:	galK
Ordered Locus Names:	SSP0629

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	386 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-galactose = ADP + alpha-D-galactose 1-phosphate. HAMAP MF_00246
Pathway	Carbohydrate metabolism; galactose metabolism. HAMAP MF_00246
Subcellular location	Cytoplasm Potential HAMAP MF_00246.
Sequence similarities	Belongs to the GHMP kinase family. GalK subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW galactokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 386	386	Galactokinase HAMAP MF_00246		PRO_1000005765
Regions
	Nucleotide binding	121 – 131	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q49ZK2 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 43B27DBA4366952C	FASTA	386	43,131
	10 20 30 40 50 60 MLQEMHKKFE SLFDVKADVR AFAPGRINLI GEHTDYNGGY VFPAAIELGT YGLASKRTDR 70 80 90 100 110 120 IIQLYSNNFE DTGIVSFTLD ELEFNEQHDW ANYPKGVVKY LKEEFNDINQ GFNILVEGNI 130 140 150 160 170 180 PNGASLSSSA SIELLTGWLI KQLFNLHLER LQLIKLGQVV ENKFMGVNSG IMDQFIIGMG 190 200 210 220 230 240 KAEHAILLDT ATLDFDYVPA KFGDYVISIM NTNKRRSLTE SKYNERRSEC ENALSQLQQQ 250 260 270 280 290 300 LEITSLGELS LAQFEKYQSL ITDEVVCRRA KHAISENERT KLAHKALADN NFEQFGQLLN 310 320 330 340 350 360 ASHKSLKEDY EVTGIELDTL AETAQQVEGV LGARMTGAGF AGCAIALVDK NSIQKLEDEV 370 380 SKAYIDKIGY APSFYHVGIS DGVKAL

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15305 / DSM 20229.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008934 Genomic DNA. Translation: BAE17774.1.
RefSeq	YP_300719.1. NC_007350.1.
3D structure databases
HSSP	HSSP built from PDB template 2AJ4 based on UniProtKB P04385.
ProteinModelPortal	Q49ZK2.
SMR	Q49ZK2. Positions 1-386.
ModBase	Search...
Protein-protein interaction databases
STRING	Q49ZK2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000048135; EBSTAP00000046504; EBSTAG00000048132.
GeneID	3616025.
GenomeReviews	Gene locus SSP0629 in contig AP008934_GR.
KEGG	ssp:SSP0629.
NMPDR	fig|342451.4.peg.808.
PATRIC	19622744. VBIStaSap90642_0632.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0153.
GeneTree	EBGT00050000026414.
HOGENOM	HBG725121.
OMA	FIISTAR.
PhylomeDB	Q49ZK2.
ProtClustDB	PRK05322.
Enzyme and pathway databases
BioCyc	SSAP342451:SSP0629-MONOMER.
Family and domain databases
HAMAP	MF_00246. Galactokinase. [Tree]
InterPro	IPR000705. Galactokinase. IPR022963. Galactokinase_bac. IPR019741. Galactokinase_CS. IPR019539. GalKase_gal-bd. IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006206. Mevalonate/galactokinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K00849.
Pfam	PF10509. GalKase_gal_bdg. 1 hit. PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000530. Galactokinase. 1 hit.
PRINTS	PR00473. GALCTOKINASE. PR00959. MEVGALKINASE.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00131. Gal_kin. 1 hit.
PROSITE	PS00106. GALACTOKINASE. 1 hit. PS00627. GHMP_KINASES_ATP. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GAL1_STAS1

Accession

Primary (citable) accession number: Q49ZK2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program