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Q49ZA6 (MTLD_STAS1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17
Gene names
Name:mtlD
Ordered Locus Names:SSP0725
OrganismStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]
Taxonomic identifier342451 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol-1-phosphate 5-dehydrogenase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196
PRO_1000011817

Regions

Nucleotide binding3 – 1412NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q49ZA6 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 55BD2C6F9CD6E0F7

FASTA36741,143
        10         20         30         40         50         60 
MKALHFGAGN IGRGFIGYIL ADNDVKVTFA DVNEEIINAL DKEHQYDVIL ADEAKTTTRV 

        70         80         90        100        110        120 
HNVDAINSGG PSESLKQAVL EADLITTAVG VNILPIIAKS FAPYLKEKET PVNIVACENA 

       130        140        150        160        170        180 
IMATNTLKDA ILDITGPLGD HIHFANSAVD RIVPLQTNDN LLDVIVEPFY EWVIEKDAWF 

       190        200        210        220        230        240 
GPELDHIKYV DNLTPYIERK LLTVNTGHAY LAYAGRFYGQ PTILDAVNDD NIRHGLENVL 

       250        260        270        280        290        300 
KETSQYITTQ FNFTESEQAQ YVDKIIGRFK NPNLSDEVTR VGRGTMRKIG PQDRIIKPLS 

       310        320        330        340        350        360 
YLYQNNLKHD ALIKTAALLL KYDDTNDQET VEKNEYIDKH GVEGFLKSFA KTDDQLTSEI 


VKEYNVL

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References

[1]"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15305 / DSM 20229.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008934 Genomic DNA. Translation: BAE17870.1.
RefSeqYP_300815.1. NC_007350.1.

3D structure databases

ProteinModelPortalQ49ZA6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ49ZA6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000047726; EBSTAP00000046095; EBSTAG00000047723.
GeneID3615926.
GenomeReviewsGene locus SSP0725 in contig AP008934_GR.
KEGGssp:SSP0725.
NMPDRfig|342451.4.peg.1138.
PATRIC19622952. VBIStaSap90642_0727.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0246.
GeneTreeEBGT00050000024485.
HOGENOMHBG568825.
OMAFANTAVD.
PhylomeDBQ49ZA6.
ProtClustDBPRK02318.

Enzyme and pathway databases

BioCycSSAP342451:SSP0725-MONOMER.

Family and domain databases

HAMAPMF_00196. Mannitol_dehydrog.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR023028. Mannitol_1_phos_5_DH.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00009.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
PROSITEPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLD_STAS1
AccessionPrimary (citable) accession number: Q49ZA6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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