Reviewed, UniProtKB/Swiss-Prot Q49ZA6 (MTLD_STAS1)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	SSP0725

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD(+) = D-fructose 6-phosphate + NADH.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	Mannitol-1-phosphate 5-dehydrogenase		PRO_1000011817
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q49ZA6-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 55BD2C6F9CD6E0F7	FASTA	367	41,143
	10 20 30 40 50 60 MKALHFGAGN IGRGFIGYIL ADNDVKVTFA DVNEEIINAL DKEHQYDVIL ADEAKTTTRV 70 80 90 100 110 120 HNVDAINSGG PSESLKQAVL EADLITTAVG VNILPIIAKS FAPYLKEKET PVNIVACENA 130 140 150 160 170 180 IMATNTLKDA ILDITGPLGD HIHFANSAVD RIVPLQTNDN LLDVIVEPFY EWVIEKDAWF 190 200 210 220 230 240 GPELDHIKYV DNLTPYIERK LLTVNTGHAY LAYAGRFYGQ PTILDAVNDD NIRHGLENVL 250 260 270 280 290 300 KETSQYITTQ FNFTESEQAQ YVDKIIGRFK NPNLSDEVTR VGRGTMRKIG PQDRIIKPLS 310 320 330 340 350 360 YLYQNNLKHD ALIKTAALLL KYDDTNDQET VEKNEYIDKH GVEGFLKSFA KTDDQLTSEI VKEYNVL

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP008934 Genomic DNA. Translation: BAE17870.1.
RefSeq	YP_300815.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3615926.
GenomeReviews	Gene locus SSP0725 in contig AP008934_GR.
KEGG	ssp:SSP0725.
NMPDR	fig|342451.4.peg.1138.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q49ZA6.
Enzyme and pathway databases
BioCyc	SSAP342451:SSP0725-MON.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DHase_multihelical. IPR013118. Mannitol_DHase_C. IPR000669. Mannitol_DHase_core. IPR013131. Mannitol_DHase_N. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_STAS1

Accession

Primary (citable) accession number: Q49ZA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 13, 2005
Last modified:	November 25, 2008
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)