Q49Z82 (DEOB_STAS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphopentomutase
EC=5.4.2.7

Alternative name(s):
Phosphodeoxyribomutase

Gene names

Name:	deoB
Synonyms:	drm
Ordered Locus Names:	SSP0749

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus saprophyticus › Staphylococcus saprophyticus subsp. saprophyticus

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphotransfer between the C1 and C5 carbon atoms of pentose By similarity. HAMAP-Rule MF_00740
Catalytic activity	Alpha-D-ribose 1-phosphate = D-ribose 5-phosphate. HAMAP-Rule MF_00740 2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-alpha-D-ribose 5-phosphate. HAMAP-Rule MF_00740
Cofactor	Binds 1 or 2 manganese ions Potential.
Pathway	Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 1/3. HAMAP-Rule MF_00740
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00740.
Sequence similarities	Belongs to the phosphopentomutase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	5-phosphoribose 1-diphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway cellular metabolic compound salvage Inferred from electronic annotation. Source: InterPro deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: InterPro manganese ion binding Inferred from electronic annotation. Source: HAMAP phosphopentomutase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	Phosphopentomutase HAMAP-Rule MF_00740		PRO_0000199848
Sites
	Metal binding	14	1	Manganese By similarity
	Metal binding	291	1	Manganese By similarity
	Metal binding	327	1	Manganese By similarity
	Metal binding	328	1	Manganese By similarity
	Metal binding	339	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q49Z82 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 5F2537C892B10FA4	FASTA	395	44,373
	10 20 30 40 50 60 MTTPFKRVHL IVMDSVGIGE GPDAKAFDDE GSHTLKHTLE GFEQSLPNLQ KLGLGNIEPL 70 80 90 100 110 120 PVIDKEVEPQ AFYTKMSEAS VGKDTMTGHW EIMGLNIMQP FKVYPEGFPE ELVNEIETLT 130 140 150 160 170 180 GRKVVANRPA SGTQIIDEWG EHQMKTGDLI VYTSADPVLQ IAAHEDIIPL EELYDICEKV 190 200 210 220 230 240 RELTKDPKYL IGRIIARPYI GEPGSFKRTS NRHDYALKPF GRTVMNELKD NGYDVIALGK 250 260 270 280 290 300 INDIFDGEGV TESIRTKDNM DGIDKLIETV QRDFNGLSFL NLVDFDALYG HRRDKPGYAQ 310 320 330 340 350 360 AIKDFDERLS ELMNHLQEED LVIITADHGN DPTADGTDHT REYIPVLMFS PKMTDYHELT 370 380 390 IDSTFSSLGA TIADNFGVKL PEFGKSYLKE MGVEK

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15305 / DSM 20229.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008934 Genomic DNA. Translation: BAE17894.1.
RefSeq	YP_300839.1. NC_007350.1.
3D structure databases
ProteinModelPortal	Q49Z82.
ModBase	Search...
Protein-protein interaction databases
STRING	342451.SSP0749.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAE17894; BAE17894; SSP0749.
GeneID	3615814.
KEGG	ssp:SSP0749.
PATRIC	19623000. VBIStaSap90642_0751.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1015.
HOGENOM	HOG000008159.
KO	K01839.
OMA	PNMAKLG.
ProtClustDB	PRK05362.
Enzyme and pathway databases
BioCyc	SSAP342451:GKFA-761-MONOMER.
UniPathway	UPA00087; UER00173.
Family and domain databases
Gene3D	3.30.70.1250. 1 hit. 3.40.720.10. 2 hits.
HAMAP	MF_00740. Phosphopentomut.
InterPro	IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core. IPR010045. DeoB. IPR006124. Metalloenzyme. IPR024052. Phosphopentomutase_DeoB_cap. [Graphical view]
Pfam	PF01676. Metalloenzyme. 1 hit. [Graphical view]
PIRSF	PIRSF001491. Ppentomutase. 1 hit.
SUPFAM	SSF53649. Alkaline_phosphatase_core. 1 hit. SSF143856. SSF143856. 1 hit.
TIGRFAMs	TIGR01696. deoB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOB_STAS1

Accession

Primary (citable) accession number: Q49Z82

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	September 13, 2005
Last modified:	May 29, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program