Q49Z66 (KITH_STAS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:	tdk
Ordered Locus Names:	SSP0765

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP MF_00124
Subunit structure	Homotetramer By similarity. HAMAP MF_00124
Subcellular location	Cytoplasm Potential HAMAP MF_00124.
Sequence similarities	Belongs to the thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW thymidine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Thymidine kinase HAMAP MF_00124		PRO_0000242809
Regions
	Nucleotide binding	15 – 22	8	ATP By similarity
	Nucleotide binding	88 – 91	4	ATP By similarity
Sites
	Active site	89	1	Proton acceptor Potential
	Metal binding	145	1	Zinc By similarity
	Metal binding	148	1	Zinc By similarity
	Metal binding	183	1	Zinc By similarity
	Metal binding	186	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q49Z66 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 26D233DFE3016B0F	FASTA	199	22,177
	10 20 30 40 50 60 MYETYHSGWI ECITGSMFSG KSEELIRRLR RGLYAKQKVV VFKPAIDDRY HKDKIVSHNG 70 80 90 100 110 120 NAIEAINIST AAEILKHDLS EVDVIGIDEV QFFENGIVHI AEQLAEKGHR VITAGLDMDF 130 140 150 160 170 180 RAQPFEPMPQ LMAVSEDVTK LQAVCAVCGA SSSRTQRLID GNPAKIDDPV ILVGANESYE 190 PRCRAHHIVA PSNTEKEEM

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15305 / DSM 20229.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008934 Genomic DNA. Translation: BAE17910.1.
RefSeq	YP_300855.1. NC_007350.1.
3D structure databases
ProteinModelPortal	Q49Z66.
SMR	Q49Z66. Positions 1-189.
ModBase	Search...
Protein-protein interaction databases
STRING	Q49Z66.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000047415; EBSTAP00000045784; EBSTAG00000047412.
GeneID	3615830.
GenomeReviews	Gene locus SSP0765 in contig AP008934_GR.
KEGG	ssp:SSP0765.
NMPDR	fig|342451.4.peg.1279.
PATRIC	19623032. VBIStaSap90642_0767.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1435.
GeneTree	EBGT00050000023861.
HOGENOM	HBG522108.
OMA	EPRCRHH.
PhylomeDB	Q49Z66.
ProtClustDB	PRK04296.
Enzyme and pathway databases
BioCyc	SSAP342451:SSP0765-MONOMER.
Family and domain databases
HAMAP	MF_00124. Thymidine_kinase. [Tree]
InterPro	IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. IPR020634. Thymidine_kinase_subgr. [Graphical view]
KO	K00857.
PANTHER	PTHR11441. TK_cell. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_STAS1

Accession

Primary (citable) accession number: Q49Z66

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program