Q49Z62 (PTPB_STAS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Low molecular weight protein-tyrosine-phosphatase PtpB
EC=3.1.3.48

Alternative name(s):
Phosphotyrosine phosphatase B
Short name=PTPase B

Gene names

Name:	ptpB
Ordered Locus Names:	SSP0769

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus saprophyticus › Staphylococcus saprophyticus subsp. saprophyticus

Protein attributes

Sequence length	140 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Dephosphorylates the phosphotyrosine-containing proteins By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Sequence similarities	Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Ontologies

Keywords
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 140	140	Low molecular weight protein-tyrosine-phosphatase PtpB		PRO_0000300683
Sites
	Active site	7	1	Nucleophile By similarity
	Active site	13	1	By similarity
	Active site	111	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q49Z62 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 48B1DB6DA157849D	FASTA	140	15,703
	10 20 30 40 50 60 MKIIFVCTGN TCRSPMAESI AQSKLPNHTI VSRGMYAIDG QPISDHTKEI LLERHLNVPY 70 80 90 100 110 120 QAQSFTASDI NADLILTMGS SHKRIIKELY DNTDHVFTLN EYVDKIGEVS DPFGGSKSAY 130 140 LEIYNELNLL IDSLKNKILN

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15305 / DSM 20229.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008934 Genomic DNA. Translation: BAE17914.1.
RefSeq	YP_300859.1. NC_007350.1.
3D structure databases
HSSP	HSSP built from PDB template 1ZGG based on UniProtKB P39155.
ProteinModelPortal	Q49Z62.
ModBase	Search...
Protein-protein interaction databases
STRING	342451.SSP0769.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAE17914; BAE17914; SSP0769.
GeneID	3615834.
KEGG	ssp:SSP0769.
PATRIC	19623040. VBIStaSap90642_0771.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0394.
HOGENOM	HOG000273091.
KO	K01104.
OMA	ERDINDP.
ProtClustDB	CLSK2464252.
Family and domain databases
InterPro	IPR023485. Ptyr_pPase_SF. IPR000106. Tyr_phospatase/Ars_reductase. IPR017867. Tyr_phospatase_low_mol_wt. [Graphical view]
PANTHER	PTHR11717. PTHR11717. 1 hit.
Pfam	PF01451. LMWPc. 1 hit. [Graphical view]
PRINTS	PR00719. LMWPTPASE.
SMART	SM00226. LMWPc. 1 hit. [Graphical view]
SUPFAM	SSF52788. Tyr_Pase_low_mol_wt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PTPB_STAS1

Accession

Primary (citable) accession number: Q49Z62

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 13, 2005
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program