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Q49Z24 (ALR_STAS1) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase

EC=5.1.1.1
Gene names
Name:alr
Ordered Locus Names:SSP0807
OrganismStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]
Taxonomic identifier342451 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-alanine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionalanine racemase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 382382Alanine racemase HAMAP-Rule MF_01201
PRO_1000138624

Sites

Active site391Proton acceptor; specific for D-alanine By similarity
Active site2651Proton acceptor; specific for L-alanine By similarity
Binding site1381Substrate By similarity
Binding site3121Substrate; via amide nitrogen By similarity

Amino acid modifications

Modified residue391N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q49Z24 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: CF5C91797DE44B59

FASTA38242,750
        10         20         30         40         50         60 
MSDKYYRSTY VNVDLNAIVA NFQVFQKLHP NKTVMPVVKA NGYGLGSIKV ARQLMDNGAE 

        70         80         90        100        110        120 
FFAVATLDEA IELRMHGIDA KILVLGVIPT EHINKAIQHR VAITVPSKSW LVEAVKEIPE 

       130        140        150        160        170        180 
SNEKDLWIHV KLDTGMGRLG MKTAEEYKEV IELINGHSHL IFEGVFTHFA CADEPGDSMN 

       190        200        210        220        230        240 
RQQTMFEEIV GQADKPDYIH SQNSAGALMK DTQFCNAVRV GISLYGYYPS AYVKSNVKVH 

       250        260        270        280        290        300 
LKPSAQWISE IVQTKLLHAG ESVSYGSVYT ADEKTKIGVI PVGYADGYPR MMKGFSVNVN 

       310        320        330        340        350        360 
GKQCEVIGKV CMDQTIIKIP DEIQVGDKVI IMDHHSDTPQ SAEALAHQQQ TINYEVLCRL 

       370        380 
SRRLPRVYHS SKDLEIRNEL LK 

« Hide

References

[1]"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15305 / DSM 20229.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008934 Genomic DNA. Translation: BAE17952.1.
RefSeqYP_300897.1. NC_007350.1.

3D structure databases

ProteinModelPortalQ49Z24.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING342451.SSP0807.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE17952; BAE17952; SSP0807.
GeneID3615774.
KEGGssp:SSP0807.
PATRIC19623116. VBIStaSap90642_0809.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000031444.
KOK01775.
OMAWRDMARR.
OrthoDBEOG6PP9NJ.

Enzyme and pathway databases

BioCycSSAP342451:GKFA-819-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR_STAS1
AccessionPrimary (citable) accession number: Q49Z24
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 13, 2005
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways