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Q49YI8

- SYL_STAS1

UniProt

Q49YI8 - SYL_STAS1

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Protein
Leucine--tRNA ligase
Gene
leuS, SSP1006
Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSAP342451:GKFA-1065-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:SSP1006
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000006371: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 804804Leucine--tRNA ligaseUniRule annotation
PRO_1000009441Add
BLAST

Proteomic databases

PRIDEiQ49YI8.

Interactioni

Protein-protein interaction databases

STRINGi342451.SSP1006.

Structurei

3D structure databases

ProteinModelPortaliQ49YI8.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotation
Add
BLAST
Motifi576 – 5805"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiNENGVEG.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49YI8-1 [UniParc]FASTAAdd to Basket

« Hide

MNYSHNEIEK KWQDYWEANK TFKTSDNLGQ KKFYALDMFP YPSGAGLHVG    50
HPEGYTATDI ISRYKRMLGY NVLHPMGWDA FGLPAEQYAL DTGNDPREFT 100
KENIQTFKRQ IKELGFSYDW DREVNTTDPE YYKWTQWIFI QLYNKGLAYV 150
DEVAVNWCPA LGTVLSNEEV IDGVSERGGH PVYRRPMKQW VLKITEYADR 200
LLEDLDELDW PESLKDMQRN WIGRSEGASV AFDVKDYNEQ IEVFTTRPDT 250
IYGASFLVLS PEHELVDLIT TEDNKDDVEA YQKEAAKKSD LERTGLSKEK 300
SGVFTGAYAV NPLSGQQVPI WIADYVLSTY GTGAVMAVPS GDQRDYEFAK 350
TFDLPIIEVI EGGDMSKEAY TGDGPHINSG ELNGLYNEAA IEKAIELLEN 400
KNAGTRKVNY KLRDWLFSRQ RYWGEPIPVI HWEDGSMTTV PEDELPLLLP 450
ETDEIKPSGT GESPLANIDE FVNVVDEATG MKGRRETNTM PQWAGSCWYY 500
LRYIDPDNEQ MLADPEKLKH WLPVDLYIGG VEHAVLHLLY ARFWHKVLFD 550
LGVVPTKEPF QKLFNQGMIL GEGNEKMSKS KGNVINPDDI VKSHGADTLR 600
LYEMFMGPLD AAIAWSENGL DGSRRFLDRI WRLLITEDGS ISNKVVNNHS 650
KALDKSYHQT VKKVTEDYNS LNFNTAISQL MVFINDCYKA EEIYKPYIEG 700
FIKMLAPIAP HISEELWSRL GHDETITYQP WPSYDEALLV DDEIEIVVQV 750
NGKVRAKINV SKDIAKEEME QIALDNEHVK SEIEGKDIKK VIAVPKKLVN 800
IVAK 804
Length:804
Mass (Da):91,860
Last modified:September 13, 2005 - v1
Checksum:i2337B733107FF07C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE18151.1.
RefSeqiWP_011302857.1. NC_007350.1.
YP_301096.1. NC_007350.1.

Genome annotation databases

EnsemblBacteriaiBAE18151; BAE18151; SSP1006.
GeneIDi3615876.
KEGGissp:SSP1006.
PATRICi19623596. VBIStaSap90642_1005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE18151.1 .
RefSeqi WP_011302857.1. NC_007350.1.
YP_301096.1. NC_007350.1.

3D structure databases

ProteinModelPortali Q49YI8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 342451.SSP1006.

Proteomic databases

PRIDEi Q49YI8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE18151 ; BAE18151 ; SSP1006 .
GeneIDi 3615876.
KEGGi ssp:SSP1006.
PATRICi 19623596. VBIStaSap90642_1005.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi NENGVEG.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SSAP342451:GKFA-1065-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
    Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
    Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15305 / DSM 20229.

Entry informationi

Entry nameiSYL_STAS1
AccessioniPrimary (citable) accession number: Q49YI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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