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Q49YI8

- SYL_STAS1

UniProt

Q49YI8 - SYL_STAS1

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei579 – 5791ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSAP342451:GKFA-1065-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:SSP1006
    OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
    Taxonomic identifieri342451 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000006371: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 804804Leucine--tRNA ligasePRO_1000009441Add
    BLAST

    Proteomic databases

    PRIDEiQ49YI8.

    Interactioni

    Protein-protein interaction databases

    STRINGi342451.SSP1006.

    Structurei

    3D structure databases

    ProteinModelPortaliQ49YI8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi576 – 5805"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiNENGVEG.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q49YI8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNYSHNEIEK KWQDYWEANK TFKTSDNLGQ KKFYALDMFP YPSGAGLHVG    50
    HPEGYTATDI ISRYKRMLGY NVLHPMGWDA FGLPAEQYAL DTGNDPREFT 100
    KENIQTFKRQ IKELGFSYDW DREVNTTDPE YYKWTQWIFI QLYNKGLAYV 150
    DEVAVNWCPA LGTVLSNEEV IDGVSERGGH PVYRRPMKQW VLKITEYADR 200
    LLEDLDELDW PESLKDMQRN WIGRSEGASV AFDVKDYNEQ IEVFTTRPDT 250
    IYGASFLVLS PEHELVDLIT TEDNKDDVEA YQKEAAKKSD LERTGLSKEK 300
    SGVFTGAYAV NPLSGQQVPI WIADYVLSTY GTGAVMAVPS GDQRDYEFAK 350
    TFDLPIIEVI EGGDMSKEAY TGDGPHINSG ELNGLYNEAA IEKAIELLEN 400
    KNAGTRKVNY KLRDWLFSRQ RYWGEPIPVI HWEDGSMTTV PEDELPLLLP 450
    ETDEIKPSGT GESPLANIDE FVNVVDEATG MKGRRETNTM PQWAGSCWYY 500
    LRYIDPDNEQ MLADPEKLKH WLPVDLYIGG VEHAVLHLLY ARFWHKVLFD 550
    LGVVPTKEPF QKLFNQGMIL GEGNEKMSKS KGNVINPDDI VKSHGADTLR 600
    LYEMFMGPLD AAIAWSENGL DGSRRFLDRI WRLLITEDGS ISNKVVNNHS 650
    KALDKSYHQT VKKVTEDYNS LNFNTAISQL MVFINDCYKA EEIYKPYIEG 700
    FIKMLAPIAP HISEELWSRL GHDETITYQP WPSYDEALLV DDEIEIVVQV 750
    NGKVRAKINV SKDIAKEEME QIALDNEHVK SEIEGKDIKK VIAVPKKLVN 800
    IVAK 804
    Length:804
    Mass (Da):91,860
    Last modified:September 13, 2005 - v1
    Checksum:i2337B733107FF07C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008934 Genomic DNA. Translation: BAE18151.1.
    RefSeqiWP_011302857.1. NC_007350.1.
    YP_301096.1. NC_007350.1.

    Genome annotation databases

    EnsemblBacteriaiBAE18151; BAE18151; SSP1006.
    GeneIDi3615876.
    KEGGissp:SSP1006.
    PATRICi19623596. VBIStaSap90642_1005.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008934 Genomic DNA. Translation: BAE18151.1 .
    RefSeqi WP_011302857.1. NC_007350.1.
    YP_301096.1. NC_007350.1.

    3D structure databases

    ProteinModelPortali Q49YI8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 342451.SSP1006.

    Proteomic databases

    PRIDEi Q49YI8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE18151 ; BAE18151 ; SSP1006 .
    GeneIDi 3615876.
    KEGGi ssp:SSP1006.
    PATRICi 19623596. VBIStaSap90642_1005.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi NENGVEG.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SSAP342451:GKFA-1065-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
      Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
      Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15305 / DSM 20229.

    Entry informationi

    Entry nameiSYL_STAS1
    AccessioniPrimary (citable) accession number: Q49YI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3