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Q49YC7

- KPYK_STAS1

UniProt

Q49YC7 - KPYK_STAS1

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Protein
Pyruvate kinase
Gene
pyk, SSP1069
Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Magnesium By similarity.
Potassium By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei32 – 321Substrate By similarity
Metal bindingi34 – 341Potassium By similarity
Metal bindingi36 – 361Potassium By similarity
Metal bindingi66 – 661Potassium By similarity
Metal bindingi67 – 671Potassium; via carbonyl oxygen By similarity
Sitei220 – 2201Transition state stabilizer By similarity
Metal bindingi222 – 2221Magnesium By similarity
Binding sitei245 – 2451Substrate; via amide nitrogen By similarity
Metal bindingi246 – 2461Magnesium By similarity
Binding sitei246 – 2461Substrate; via amide nitrogen By similarity
Binding sitei278 – 2781Substrate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

BioCyciSSAP342451:GKFA-1128-MONOMER.
UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:pyk
Ordered Locus Names:SSP1069
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000006371: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 586586Pyruvate kinase
PRO_0000294140Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi342451.SSP1069.

Structurei

3D structure databases

ProteinModelPortaliQ49YC7.
SMRiQ49YC7. Positions 2-586.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.
In the C-terminal section; belongs to the PEP-utilizing enzyme family.

Phylogenomic databases

eggNOGiCOG0469.
HOGENOMiHOG000021559.
KOiK00873.
OMAiIENHEGM.
OrthoDBiEOG6GBMB0.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
3.50.30.10. 1 hit.
InterProiIPR008279. PEP-util_enz_mobile_dom.
IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00391. PEP-utilizers. 1 hit.
PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52009. SSF52009. 1 hit.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49YC7-1 [UniParc]FASTAAdd to Basket

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MRKTKIVCTI GPASESEEML EKLIKAGMNV ARLNFSHGDQ AEHKARIDTI    50
RKVSKRLGKT VAILLDTKGP EIRTHNMKDG LIELEKGSEV TVSMTEVEGT 100
PEKFSVTYEN LINDVEEGSY ILLDDGLIEL QVKSIDKANG EVLCDVLNTG 150
ELKNKKGVNL PGVKVSLPGI TDKDADDINF GISEGVDFIA ASFVRRPSDV 200
LDIRKLLEAK QNKNISIIPK IENQEGIDNI KEILEVSDGL MVARGDMGVE 250
IPPESVPMVQ KDLIRQCNKL GKPVITATQM LDSMQRNPRA TRAEASDVAN 300
AIYDGTDAVM LSGETAAGQY PEEAVKTMRN IAVSAEAAQD YKKLLSDRTK 350
LVETSLVNAI GVSVAHTALN LNVKAIVAAT ESGSTARTIS KYRPQSDIIA 400
VTPNAETARQ CALVWGIFPV VKEGRKTTDA LLNNAVATAV ETERVQNGDL 450
IIITAGVPTG EKGTTNMMKL HLVGDELAKG QGIGRSSVVG KTLVVKDASE 500
LEGKDLSESI IVTSSVDETL VPYIENAIGL ITEENGITSP SAIIGLEKGI 550
PTVVGVENAT SEIQSDVLIT VDANQGKIFE GYANVL 586
Length:586
Mass (Da):62,853
Last modified:September 13, 2005 - v1
Checksum:iFE093F0E7D948CAE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE18214.1.
RefSeqiWP_011302911.1. NC_007350.1.
YP_301159.1. NC_007350.1.

Genome annotation databases

EnsemblBacteriaiBAE18214; BAE18214; SSP1069.
GeneIDi3615437.
KEGGissp:SSP1069.
PATRICi19623722. VBIStaSap90642_1068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE18214.1 .
RefSeqi WP_011302911.1. NC_007350.1.
YP_301159.1. NC_007350.1.

3D structure databases

ProteinModelPortali Q49YC7.
SMRi Q49YC7. Positions 2-586.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 342451.SSP1069.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE18214 ; BAE18214 ; SSP1069 .
GeneIDi 3615437.
KEGGi ssp:SSP1069.
PATRICi 19623722. VBIStaSap90642_1068.

Phylogenomic databases

eggNOGi COG0469.
HOGENOMi HOG000021559.
KOi K00873.
OMAi IENHEGM.
OrthoDBi EOG6GBMB0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .
BioCyci SSAP342451:GKFA-1128-MONOMER.

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
3.50.30.10. 1 hit.
InterProi IPR008279. PEP-util_enz_mobile_dom.
IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00391. PEP-utilizers. 1 hit.
PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52009. SSF52009. 1 hit.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
    Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
    Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15305 / DSM 20229.

Entry informationi

Entry nameiKPYK_STAS1
AccessioniPrimary (citable) accession number: Q49YC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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