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Q49YC4

- Q49YC4_STAS1

UniProt

Q49YC4 - Q49YC4_STAS1

Protein

Isocitrate dehydrogenase [NADP]

Gene

SSP1072

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation
    Binds 1 magnesium or manganese ion per subunit By similarity.

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciSSAP342451:GKFA-1131-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:SSP1072Imported
    OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)Imported
    Taxonomic identifieri342451 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000006371: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi342451.SSP1072.

    Structurei

    3D structure databases

    ProteinModelPortaliQ49YC4.
    SMRiQ49YC4. Positions 3-421.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiTNLFMDV.
    OrthoDBiEOG6SNDTP.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q49YC4-1 [UniParc]FASTAAdd to Basket

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    MAGEKVAKTN EGLTVPNNPI IPFIIGDGIG PDIWKAASRV IDAAVEQAYN    50
    GEKKIEWKEV LAGQKAYDET GEWLPQATLD TIEEYLIAIK GPLTTPIGGG 100
    IRSLNVALRQ ELDLFTCLRP VRWFQGVPSP VKRPEDTDMV IFRENTEDIY 150
    AGIEFKEGTP EVKKLIDFLQ DEMGAKNIRF PETSGIGVKP VSKEGTERLV 200
    RAAIQYAVDN NRKSLTLVHK GNIMKFTEGA FKQWGYDVAH NEFGDKVFTW 250
    QQYDEIVEKE GKDKANAAQE QAEKDGKIIV KDSIADIFLQ QILTRPSDHD 300
    VVATMNLNGD YVSDALAAQV GGIGIAPGAN INYETGHAIF EATHGTAPKY 350
    ADLNKVNPSS EILSAVLMLE HLGWQEAADK ITASIEKTIA SKVVTYDFAR 400
    LMDGAKEVST SDFADELIKN L 421
    Length:421
    Mass (Da):46,344
    Last modified:September 13, 2005 - v1
    Checksum:i117EF19CDE7A33C6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008934 Genomic DNA. Translation: BAE18217.1.
    RefSeqiWP_011302914.1. NC_007350.1.
    YP_301162.1. NC_007350.1.

    Genome annotation databases

    EnsemblBacteriaiBAE18217; BAE18217; SSP1072.
    GeneIDi3615440.
    KEGGissp:SSP1072.
    PATRICi19623728. VBIStaSap90642_1071.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008934 Genomic DNA. Translation: BAE18217.1 .
    RefSeqi WP_011302914.1. NC_007350.1.
    YP_301162.1. NC_007350.1.

    3D structure databases

    ProteinModelPortali Q49YC4.
    SMRi Q49YC4. Positions 3-421.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 342451.SSP1072.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE18217 ; BAE18217 ; SSP1072 .
    GeneIDi 3615440.
    KEGGi ssp:SSP1072.
    PATRICi 19623728. VBIStaSap90642_1071.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi TNLFMDV.
    OrthoDBi EOG6SNDTP.

    Enzyme and pathway databases

    BioCyci SSAP342451:GKFA-1131-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
      Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
      Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15305 / DSM 20229Imported.

    Entry informationi

    Entry nameiQ49YC4_STAS1
    AccessioniPrimary (citable) accession number: Q49YC4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 13, 2005
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3