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Q49YC4

- Q49YC4_STAS1

UniProt

Q49YC4 - Q49YC4_STAS1

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Protein

Isocitrate dehydrogenase [NADP]

Gene
SSP1072
Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciSSAP342451:GKFA-1131-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:SSP1072Imported
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)Imported
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000006371: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi342451.SSP1072.

Structurei

3D structure databases

ProteinModelPortaliQ49YC4.
SMRiQ49YC4. Positions 3-421.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiTNLFMDV.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49YC4-1 [UniParc]FASTAAdd to Basket

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MAGEKVAKTN EGLTVPNNPI IPFIIGDGIG PDIWKAASRV IDAAVEQAYN    50
GEKKIEWKEV LAGQKAYDET GEWLPQATLD TIEEYLIAIK GPLTTPIGGG 100
IRSLNVALRQ ELDLFTCLRP VRWFQGVPSP VKRPEDTDMV IFRENTEDIY 150
AGIEFKEGTP EVKKLIDFLQ DEMGAKNIRF PETSGIGVKP VSKEGTERLV 200
RAAIQYAVDN NRKSLTLVHK GNIMKFTEGA FKQWGYDVAH NEFGDKVFTW 250
QQYDEIVEKE GKDKANAAQE QAEKDGKIIV KDSIADIFLQ QILTRPSDHD 300
VVATMNLNGD YVSDALAAQV GGIGIAPGAN INYETGHAIF EATHGTAPKY 350
ADLNKVNPSS EILSAVLMLE HLGWQEAADK ITASIEKTIA SKVVTYDFAR 400
LMDGAKEVST SDFADELIKN L 421
Length:421
Mass (Da):46,344
Last modified:September 13, 2005 - v1
Checksum:i117EF19CDE7A33C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE18217.1.
RefSeqiWP_011302914.1. NC_007350.1.
YP_301162.1. NC_007350.1.

Genome annotation databases

EnsemblBacteriaiBAE18217; BAE18217; SSP1072.
GeneIDi3615440.
KEGGissp:SSP1072.
PATRICi19623728. VBIStaSap90642_1071.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE18217.1 .
RefSeqi WP_011302914.1. NC_007350.1.
YP_301162.1. NC_007350.1.

3D structure databases

ProteinModelPortali Q49YC4.
SMRi Q49YC4. Positions 3-421.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 342451.SSP1072.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE18217 ; BAE18217 ; SSP1072 .
GeneIDi 3615440.
KEGGi ssp:SSP1072.
PATRICi 19623728. VBIStaSap90642_1071.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi TNLFMDV.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci SSAP342451:GKFA-1131-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
    Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
    Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15305 / DSM 20229.

Entry informationi

Entry nameiQ49YC4_STAS1
AccessioniPrimary (citable) accession number: Q49YC4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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