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Q49XX9

- GCSPB_STAS1

UniProt

Q49XX9 - GCSPB_STAS1

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 2
Gene
gcvPB, SSP1220
Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSSAP342451:GKFA-1279-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:SSP1220
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000006371: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation
PRO_0000167020Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei274 – 2741N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi342451.SSP1220.

Structurei

3D structure databases

ProteinModelPortaliQ49XX9.
SMRiQ49XX9. Positions 6-485.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q49XX9-1 [UniParc]FASTAAdd to Basket

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MVVSKSSPLI FERSKKGRYA YSLPKKEIDN GAVEKLLDDK FIRKNKAELP    50
EVAELDLVRH YTELSNKNFG VDSGFYPLGS CTMKYNPKIN EKIARIPGFA 100
ESHPLQDESQ VQGSLEIIHS LQEELKEITG MDEVTLQPAA GAHGEWTALM 150
IFKAFHQKNG EGHRDEVIVP DSAHGTNPAS AAFAGFKAVT VKSNERGEVD 200
IDDLKRVVNE NTAAIMLTNP NTLGIFEKNI MDIRNIVHEA GGLLYYDGAN 250
LNAIMDKVRP GDMGFDAVHL NLHKTFTGPH GGGGPGSGPV GVKKELASFL 300
PKPMVVKEDD VYKYDNDIEN SIGRVKPFYG NFGIYLRAYT YIRTMGNKGL 350
EEVSEAAVLN ANYIKARLKD HFEIPYPQYC KHEFVLSGSK QKEHGVRTLD 400
MAKRLLDFGV HPPTIYFPLN VEEGMMIEPT ETESKETLDY FCDKMIEIAN 450
EAKEDPDKVL EAPHTTIIDR LDETKAARQP VLKFENLRSE KE 492
Length:492
Mass (Da):55,035
Last modified:September 13, 2005 - v1
Checksum:iCFD1C854A95D2812
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE18365.1.
RefSeqiYP_301310.1. NC_007350.1.

Genome annotation databases

EnsemblBacteriaiBAE18365; BAE18365; SSP1220.
GeneIDi3616987.
KEGGissp:SSP1220.
PATRICi19624024. VBIStaSap90642_1219.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE18365.1 .
RefSeqi YP_301310.1. NC_007350.1.

3D structure databases

ProteinModelPortali Q49XX9.
SMRi Q49XX9. Positions 6-485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 342451.SSP1220.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE18365 ; BAE18365 ; SSP1220 .
GeneIDi 3616987.
KEGGi ssp:SSP1220.
PATRICi 19624024. VBIStaSap90642_1219.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SSAP342451:GKFA-1279-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
    Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
    Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15305 / DSM 20229.

Entry informationi

Entry nameiGCSPB_STAS1
AccessioniPrimary (citable) accession number: Q49XX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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