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Q49XX9

- GCSPB_STAS1

UniProt

Q49XX9 - GCSPB_STAS1

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSSAP342451:GKFA-1279-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:SSP1220
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000006371: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_0000167020Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei274 – 2741N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi342451.SSP1220.

Structurei

3D structure databases

ProteinModelPortaliQ49XX9.
SMRiQ49XX9. Positions 6-485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q49XX9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVVSKSSPLI FERSKKGRYA YSLPKKEIDN GAVEKLLDDK FIRKNKAELP
60 70 80 90 100
EVAELDLVRH YTELSNKNFG VDSGFYPLGS CTMKYNPKIN EKIARIPGFA
110 120 130 140 150
ESHPLQDESQ VQGSLEIIHS LQEELKEITG MDEVTLQPAA GAHGEWTALM
160 170 180 190 200
IFKAFHQKNG EGHRDEVIVP DSAHGTNPAS AAFAGFKAVT VKSNERGEVD
210 220 230 240 250
IDDLKRVVNE NTAAIMLTNP NTLGIFEKNI MDIRNIVHEA GGLLYYDGAN
260 270 280 290 300
LNAIMDKVRP GDMGFDAVHL NLHKTFTGPH GGGGPGSGPV GVKKELASFL
310 320 330 340 350
PKPMVVKEDD VYKYDNDIEN SIGRVKPFYG NFGIYLRAYT YIRTMGNKGL
360 370 380 390 400
EEVSEAAVLN ANYIKARLKD HFEIPYPQYC KHEFVLSGSK QKEHGVRTLD
410 420 430 440 450
MAKRLLDFGV HPPTIYFPLN VEEGMMIEPT ETESKETLDY FCDKMIEIAN
460 470 480 490
EAKEDPDKVL EAPHTTIIDR LDETKAARQP VLKFENLRSE KE
Length:492
Mass (Da):55,035
Last modified:September 13, 2005 - v1
Checksum:iCFD1C854A95D2812
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA. Translation: BAE18365.1.
RefSeqiWP_011303029.1. NC_007350.1.
YP_301310.1. NC_007350.1.

Genome annotation databases

EnsemblBacteriaiBAE18365; BAE18365; SSP1220.
GeneIDi3616987.
KEGGissp:SSP1220.
PATRICi19624024. VBIStaSap90642_1219.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA. Translation: BAE18365.1 .
RefSeqi WP_011303029.1. NC_007350.1.
YP_301310.1. NC_007350.1.

3D structure databases

ProteinModelPortali Q49XX9.
SMRi Q49XX9. Positions 6-485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 342451.SSP1220.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE18365 ; BAE18365 ; SSP1220 .
GeneIDi 3616987.
KEGGi ssp:SSP1220.
PATRICi 19624024. VBIStaSap90642_1219.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SSAP342451:GKFA-1279-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
    Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
    Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15305 / DSM 20229.

Entry informationi

Entry nameiGCSPB_STAS1
AccessioniPrimary (citable) accession number: Q49XX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: September 13, 2005
Last modified: November 26, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3