ID   P5CR_STAS1              Reviewed;         271 AA.
AC   Q49XV0;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Pyrroline-5-carboxylate reductase;
DE            Short=P5C reductase;
DE            Short=P5CR;
DE            EC=1.5.1.2;
GN   Name=proC; OrderedLocusNames=SSP1250;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 /
OS   DSM 20229).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K.,
RA   Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S.,
RA   Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- CATALYTIC ACTIVITY: L-proline + NAD(P)(+) = 1-pyrroline-5-
CC       carboxylate + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-
CC       proline from L-glutamate 5-semialdehyde: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase
CC       family.
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DR   EMBL; AP008934; BAE18395.1; -; Genomic_DNA.
DR   RefSeq; YP_301340.1; -.
DR   GeneID; 3616880; -.
DR   GenomeReviews; AP008934_GR; SSP1250.
DR   KEGG; ssp:SSP1250; -.
DR   NMPDR; fig|342451.4.peg.666; -.
DR   HOGENOM; Q49XV0; -.
DR   OMA; Q49XV0; AMPNTSA.
DR   BioCyc; SSAP342451:SSP1250-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006561; P:proline biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR004455; NADP_OxRdtase_F420.
DR   InterPro; IPR000304; P5CR.
DR   PANTHER; PTHR11645; P5CR; 1.
DR   Pfam; PF03807; F420_oxidored; 1.
DR   PIRSF; PIRSF000193; Pyrrol-5-carb_rd; 1.
DR   TIGRFAMs; TIGR00112; proC; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP;
KW   Oxidoreductase; Proline biosynthesis.
FT   CHAIN         1    271       Pyrroline-5-carboxylate reductase.
FT                                /FTId=PRO_0000187307.
SQ   SEQUENCE   271 AA;  29870 MW;  A44EB03C234708DB CRC64;
     MKLVFYGAGN MAHAIFTGIV NSKVIDSNDI YLTNRSNEVA LKEYAEKLGV NYSYDDEALL
     KAADYVFLGT KPYDFESLAE RIKPFITDKN KFISIMAGLP ISYIREKLEA DNPIARIMPN
     TNAHVGHSVT GISFSSNFGP NSKDEVDELI NAFGSAIEVP EDNLHQVTAI TGSGPAFLYH
     VFEQYVTAGT RLGLEKAQVE ESIRNLIIGT SKMIERSELS MEQLRKNITS KGGTTQAGLN
     ALSQHDLESV FEDCLRAAVD RSVELSSQDE D
//