Reviewed, UniProtKB/Swiss-Prot Q49XV0 (P5CR_STAS1)

Names and origin

Protein names

Recommended name:
    Pyrroline-5-carboxylate reductase
      Short name=P5C reductase
      Short name=P5CR
    EC=1.5.1.2

Gene names

Name:	proC
Ordered Locus Names:	SSP1250

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Pyrroline-5-carboxylate reductase		PRO_0000187307

Sequences

	Sequence		Length	Mass (Da)
	Q49XV0-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: A44EB03C234708DB	FASTA	271	29,870
	10 20 30 40 50 60 MKLVFYGAGN MAHAIFTGIV NSKVIDSNDI YLTNRSNEVA LKEYAEKLGV NYSYDDEALL 70 80 90 100 110 120 KAADYVFLGT KPYDFESLAE RIKPFITDKN KFISIMAGLP ISYIREKLEA DNPIARIMPN 130 140 150 160 170 180 TNAHVGHSVT GISFSSNFGP NSKDEVDELI NAFGSAIEVP EDNLHQVTAI TGSGPAFLYH 190 200 210 220 230 240 VFEQYVTAGT RLGLEKAQVE ESIRNLIIGT SKMIERSELS MEQLRKNITS KGGTTQAGLN 250 260 270 ALSQHDLESV FEDCLRAAVD RSVELSSQDE D

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP008934 Genomic DNA. Translation: BAE18395.1.
RefSeq	YP_301340.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3616880.
GenomeReviews	Gene locus SSP1250 in contig AP008934_GR.
KEGG	ssp:SSP1250.
NMPDR	fig|342451.4.peg.666.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q49XV0.
Enzyme and pathway databases
BioCyc	SSAP342451:SSP1250-MON.
Family and domain databases
InterPro	IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view]
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
TIGRFAMs	TIGR00112. proC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

P5CR_STAS1

Accession

Primary (citable) accession number: Q49XV0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	September 13, 2005
Last modified:	November 25, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)