Q49XN5 (Q49XN5_STAS1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA 2 HAMAP MF_01401
Short name=Protein-methionine-S-oxide reductase 2 HAMAP MF_01401
EC=1.8.4.11 HAMAP MF_01401

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase 2 HAMAP MF_01401

Gene names

Name:	msrA2 HAMAP MF_01401
Ordered Locus Names:	SSP1315

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 SAAS SAAS002569 Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 SAAS SAAS002569
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family. HAMAP MF_01401

Ontologies

Keywords
Molecular function	Oxidoreductase HAMAP MF_01401 SAAS SAAS002569
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	10	1	By similarity HAMAP MF_01401

Sequences

	Sequence		Length	Mass (Da)
	Q49XN5 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 8671707916DA2643	FASTA	175	20,191
	10 20 30 40 50 60 MAYATLAGGC FWCLVKPFTS YPGIENVVSG YSGGHTDNPT YESVSTNQTG HVEAVQITYN 70 80 90 100 110 120 SEITSFENIL DVYFKTFDPT DNGGQFFDRG EHYEPAIFYH DENQKKAAEA KIQQLNEQGI 130 140 150 160 170 FNKPVITPIK PYKNFYPAET YHQDYYKKNP LHYEQYQRGS GRKNFIEKHW GKQND

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008934 Genomic DNA. Translation: BAE18460.1.
RefSeq	YP_301405.1. NC_007350.1.
3D structure databases
ProteinModelPortal	Q49XN5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q49XN5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000049043; EBSTAP00000047412; EBSTAG00000049040.
GeneID	3616555.
GenomeReviews	Gene locus SSP1315 in contig AP008934_GR.
KEGG	ssp:SSP1315.
NMPDR	fig|342451.4.peg.1432.
PATRIC	19624220. VBIStaSap90642_1317.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
GeneTree	EBGT00050000024265.
HOGENOM	HBG748152.
OMA	YEEVCTN.
PhylomeDB	Q49XN5.
ProtClustDB	PRK13014.
Enzyme and pathway databases
BioCyc	SSAP342451:SSP1315-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q49XN5_STAS1

Accession

Primary (citable) accession number: Q49XN5

Entry history

Integrated into UniProtKB/TrEMBL:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)