ID   ARLS_STAS1              Reviewed;         451 AA.
AC   Q49XM6;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 34.
DE   RecName: Full=Signal transduction histidine-protein kinase arlS;
DE            EC=2.7.13.3;
GN   Name=arlS; OrderedLocusNames=SSP1324;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 /
OS   DSM 20229).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K.,
RA   Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S.,
RA   Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- FUNCTION: Member of the two-component regulatory system arlS/arlR.
CC       ArlS probably functions as a sensor protein kinase which is
CC       autophosphorylated at a histidine residue and transfers its
CC       phosphate group to arlR (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + protein L-histidine = ADP + protein N-
CC       phospho-L-histidine.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (By similarity).
CC   -!- PTM: Autophosphorylated (By similarity).
CC   -!- SIMILARITY: Contains 1 HAMP domain.
CC   -!- SIMILARITY: Contains 1 histidine kinase domain.
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DR   EMBL; AP008934; BAE18469.1; -; Genomic_DNA.
DR   RefSeq; YP_301414.1; -.
DR   GeneID; 3616662; -.
DR   GenomeReviews; AP008934_GR; SSP1324.
DR   KEGG; ssp:SSP1324; -.
DR   NMPDR; fig|342451.4.peg.604; -.
DR   HOGENOM; Q49XM6; -.
DR   OMA; Q49XM6; FIDNAMK.
DR   BioCyc; SSAP342451:SSP1324-MON; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:two-component sensor activity; IEA:InterPro.
DR   GO; GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.
DR   GO; GO:0000160; P:two-component signal transduction system (p...; IEA:UniProtKB-KW.
DR   InterPro; IPR003594; ATP_bd_ATPase.
DR   InterPro; IPR003660; HAMP_linker_domain.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   InterPro; IPR003661; Sig_transdc_His_kin_sub1_dim/P.
DR   InterPro; IPR005467; Sig_transdc_His_kinase_core.
DR   Gene3D; G3DSA:3.30.565.10; ATP_bd_ATPase; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Complete proteome; Kinase; Membrane;
KW   Nucleotide-binding; Phosphoprotein; Transferase; Transmembrane;
KW   Two-component regulatory system.
FT   CHAIN         1    451       Signal transduction histidine-protein
FT                                kinase arlS.
FT                                /FTId=PRO_0000293452.
FT   TRANSMEM     12     32       Potential.
FT   TRANSMEM    156    176       Potential.
FT   DOMAIN      178    231       HAMP.
FT   DOMAIN      239    451       Histidine kinase.
FT   MOD_RES     242    242       Phosphohistidine; by autocatalysis (By
FT                                similarity).
SQ   SEQUENCE   451 AA;  52423 MW;  0750F2CF493D1AC8 CRC64;
     MKQRKLKTKW MLITTTITFL TIFLFSIIII FFLSNSLRHN EVDEAERSSE DIVKLFESKQ
     IEHVTPLDLN ASLGNFQKVM LFNEDGHKLM ETSNDNSITF SPNIVPTNVN RIAVKSDHKK
     DYLIITDHIE SPKFNGYSVI VHSLEDYKAL VNSLYFIALI FGVIATFITA IISYFFSSQI
     TKPLILMSNK MQQIRRDGFQ EKVELSTNYE ETDNLIVTFN EMMLQLEESF NQQRQFVEDA
     SHELRTPLQI IQGHLNLINR WGKKDAAILE ESLDISLEEM TRITKLVEEL LLLTKDNNNS
     RDGEIENVEI NQEIASRIKS LSQLHSDYTF EFDAFPKPLN IKIDRYQFEQ MLIIFIDNAM
     KYDQINKYIQ IQTKLRNKQI SIEITDHGVG IPKEDIEFIF DRFYRVDKSR SRKLGGNGLG
     LSIAKKIIEL NNGTIHVDSE VDKYTTFKIT F
//