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Q49XM5

- ODO1_STAS1

UniProt

Q49XM5 - ODO1_STAS1

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Protein
2-oxoglutarate dehydrogenase E1 component
Gene
odhA, SSP1325
Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

Thiamine pyrophosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciSSAP342451:GKFA-1384-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:odhA
Ordered Locus Names:SSP1325
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000006371: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9339332-oxoglutarate dehydrogenase E1 componentUniRule annotation
PRO_0000162185Add
BLAST

Proteomic databases

PRIDEiQ49XM5.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi342451.SSP1325.

Structurei

3D structure databases

ProteinModelPortaliQ49XM5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiQHAPNKE.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q49XM5-1 [UniParc]FASTAAdd to Basket

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MSNESQVSEA PVNFGANLGY VLDLYDIYLD NPSAVPEDLQ VLFSTIKNGE    50
ANIATNTEGQ SNVTKGDSTI KRVMRLIDNI RQYGHLLADI YPVNRPQREN 100
VPKLNMEDFN LDQETLESIS AGIVSEHFKD IYDNAYEAIV RMEKRYKGPI 150
AFEYTHINNN RERVWLKRRI ETPYKATLND NQKIELFKNL AHVEGFEKYL 200
HKNFVGAKRF SIEGVDTLVP MLQQTLRIAS DEGIQNIQIG MAHRGRLNVL 250
THVLEKPYEM MISEFMHIDP MKFLPEDGSL QLTSGWTGDV KYHLGGVKTT 300
QSYGSEQRIS LANNPSHLEI VAPVVLGKTR ANQDTTDKPG AVTTEFKKSM 350
PILIHGDAAY PGQGINFEAM NLGNLEGYST GGSLHIITNN RIGFTTEPED 400
GRSTTYSSDV AKGYDVPIMH VNADNVEATI EAIEIAMAFR KEFNKDVVID 450
LVGYRRYGHN EMDEPSITNP LQYYEIRKHE SVDILYGKQL VNENIISENQ 500
MNQIFDDVQN TLRAAHDKID KNDKMDNPDM QKPDSLAEPI QTKDEEVSYE 550
QLKEINDAML SYPSDFNVLK KLNKVLEKRR EPFESEDGLV DWAQAEQLAF 600
ATITQNGRPI RLTGQDSERG TFSHRHAVLH DPDTGAQYVP LHNVPDQKAT 650
FEVRNSPLSE AAVVGFEYGY NIQNKSCMTI WEAQYGDFSN MAQMIFDNFL 700
FSSRAKWGER SGLTLFLPHS FEGQGPEHSS ARLERFLQLA GENNSTIVNL 750
SSSSNYFHLL RAQAANLGTQ SMRPLVVMSP KSLLRNKTVA DPISKFTSGK 800
FEPILPEAHD KASVKKVILA SGKMFIDLKE YLTKNPNKSI LLVAVERLYP 850
FPADEIDALL SELPNLEHVA WVQEEPKNQG AWSFVYPYLK ELTTDKYDLS 900
YHGRIQRSAP AEGDGEIHKL VQNMIIEQST NIN 933
Length:933
Mass (Da):105,479
Last modified:September 13, 2005 - v1
Checksum:i603C12A85D1562EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE18470.1.
RefSeqiYP_301415.1. NC_007350.1.

Genome annotation databases

EnsemblBacteriaiBAE18470; BAE18470; SSP1325.
GeneIDi3616663.
KEGGissp:SSP1325.
PATRICi19624242. VBIStaSap90642_1328.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE18470.1 .
RefSeqi YP_301415.1. NC_007350.1.

3D structure databases

ProteinModelPortali Q49XM5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 342451.SSP1325.

Proteomic databases

PRIDEi Q49XM5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE18470 ; BAE18470 ; SSP1325 .
GeneIDi 3616663.
KEGGi ssp:SSP1325.
PATRICi 19624242. VBIStaSap90642_1328.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi QHAPNKE.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci SSAP342451:GKFA-1384-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
    Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
    Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15305 / DSM 20229.

Entry informationi

Entry nameiODO1_STAS1
AccessioniPrimary (citable) accession number: Q49XM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: September 13, 2005
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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