Q49XM5 (ODO1_STAS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-oxoglutarate dehydrogenase E1 component
EC=1.2.4.2

Alternative name(s):
Alpha-ketoglutarate dehydrogenase

Gene names

Name:	odhA
Ordered Locus Names:	SSP1325

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus saprophyticus › Staphylococcus saprophyticus subsp. saprophyticus

Protein attributes

Sequence length	933 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. HAMAP-Rule MF_01169
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP-Rule MF_01169
Cofactor	Thiamine pyrophosphate By similarity. HAMAP-Rule MF_01169
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_01169
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: HAMAP thiamine pyrophosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 933	933	2-oxoglutarate dehydrogenase E1 component HAMAP-Rule MF_01169		PRO_0000162185

Sequences

	Sequence		Length	Mass (Da)
	Q49XM5 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 603C12A85D1562EB	FASTA	933	105,479
	10 20 30 40 50 60 MSNESQVSEA PVNFGANLGY VLDLYDIYLD NPSAVPEDLQ VLFSTIKNGE ANIATNTEGQ 70 80 90 100 110 120 SNVTKGDSTI KRVMRLIDNI RQYGHLLADI YPVNRPQREN VPKLNMEDFN LDQETLESIS 130 140 150 160 170 180 AGIVSEHFKD IYDNAYEAIV RMEKRYKGPI AFEYTHINNN RERVWLKRRI ETPYKATLND 190 200 210 220 230 240 NQKIELFKNL AHVEGFEKYL HKNFVGAKRF SIEGVDTLVP MLQQTLRIAS DEGIQNIQIG 250 260 270 280 290 300 MAHRGRLNVL THVLEKPYEM MISEFMHIDP MKFLPEDGSL QLTSGWTGDV KYHLGGVKTT 310 320 330 340 350 360 QSYGSEQRIS LANNPSHLEI VAPVVLGKTR ANQDTTDKPG AVTTEFKKSM PILIHGDAAY 370 380 390 400 410 420 PGQGINFEAM NLGNLEGYST GGSLHIITNN RIGFTTEPED GRSTTYSSDV AKGYDVPIMH 430 440 450 460 470 480 VNADNVEATI EAIEIAMAFR KEFNKDVVID LVGYRRYGHN EMDEPSITNP LQYYEIRKHE 490 500 510 520 530 540 SVDILYGKQL VNENIISENQ MNQIFDDVQN TLRAAHDKID KNDKMDNPDM QKPDSLAEPI 550 560 570 580 590 600 QTKDEEVSYE QLKEINDAML SYPSDFNVLK KLNKVLEKRR EPFESEDGLV DWAQAEQLAF 610 620 630 640 650 660 ATITQNGRPI RLTGQDSERG TFSHRHAVLH DPDTGAQYVP LHNVPDQKAT FEVRNSPLSE 670 680 690 700 710 720 AAVVGFEYGY NIQNKSCMTI WEAQYGDFSN MAQMIFDNFL FSSRAKWGER SGLTLFLPHS 730 740 750 760 770 780 FEGQGPEHSS ARLERFLQLA GENNSTIVNL SSSSNYFHLL RAQAANLGTQ SMRPLVVMSP 790 800 810 820 830 840 KSLLRNKTVA DPISKFTSGK FEPILPEAHD KASVKKVILA SGKMFIDLKE YLTKNPNKSI 850 860 870 880 890 900 LLVAVERLYP FPADEIDALL SELPNLEHVA WVQEEPKNQG AWSFVYPYLK ELTTDKYDLS 910 920 930 YHGRIQRSAP AEGDGEIHKL VQNMIIEQST NIN

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15305 / DSM 20229.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008934 Genomic DNA. Translation: BAE18470.1.
RefSeq	YP_301415.1. NC_007350.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	342451.SSP1325.
Proteomic databases
PRIDE	Q49XM5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAE18470; BAE18470; SSP1325.
GeneID	3616663.
KEGG	ssp:SSP1325.
PATRIC	19624242. VBIStaSap90642_1328.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0567.
HOGENOM	HOG000259588.
KO	K00164.
OMA	TKFLGQK.
ProtClustDB	PRK09404.
Enzyme and pathway databases
BioCyc	SSAP342451:GKFA-1384-MONOMER.
Family and domain databases
HAMAP	MF_01169. SucA_OdhA.
InterPro	IPR011603. 2oxoglutarate_DH_E1. IPR023784. 2oxoglutarate_DH_E1_bac. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
PANTHER	PTHR23152. PTHR23152. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ODO1_STAS1

Accession

Primary (citable) accession number: Q49XM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	September 13, 2005
Last modified:	May 29, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program