Reviewed, UniProtKB/Swiss-Prot Q49XM5 (ODO1_STAS1)

Names and origin

Protein names

Recommended name:
    2-oxoglutarate dehydrogenase E1 component
    EC=1.2.4.2
Alternative name(s):
    Alpha-ketoglutarate dehydrogenase

Gene names

Name:	odhA
Ordered Locus Names:	SSP1325

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	933 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2). HAMAP MF_01169
Cofactor	Thiamine pyrophosphate By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: HAMAP thiamin pyrophosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 933	933	2-oxoglutarate dehydrogenase E1 component HAMAP MF_01169		PRO_0000162185

Sequences

	Sequence		Length	Mass (Da)
	Q49XM5-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 603C12A85D1562EB	FASTA	933	105,479
	10 20 30 40 50 60 MSNESQVSEA PVNFGANLGY VLDLYDIYLD NPSAVPEDLQ VLFSTIKNGE ANIATNTEGQ 70 80 90 100 110 120 SNVTKGDSTI KRVMRLIDNI RQYGHLLADI YPVNRPQREN VPKLNMEDFN LDQETLESIS 130 140 150 160 170 180 AGIVSEHFKD IYDNAYEAIV RMEKRYKGPI AFEYTHINNN RERVWLKRRI ETPYKATLND 190 200 210 220 230 240 NQKIELFKNL AHVEGFEKYL HKNFVGAKRF SIEGVDTLVP MLQQTLRIAS DEGIQNIQIG 250 260 270 280 290 300 MAHRGRLNVL THVLEKPYEM MISEFMHIDP MKFLPEDGSL QLTSGWTGDV KYHLGGVKTT 310 320 330 340 350 360 QSYGSEQRIS LANNPSHLEI VAPVVLGKTR ANQDTTDKPG AVTTEFKKSM PILIHGDAAY 370 380 390 400 410 420 PGQGINFEAM NLGNLEGYST GGSLHIITNN RIGFTTEPED GRSTTYSSDV AKGYDVPIMH 430 440 450 460 470 480 VNADNVEATI EAIEIAMAFR KEFNKDVVID LVGYRRYGHN EMDEPSITNP LQYYEIRKHE 490 500 510 520 530 540 SVDILYGKQL VNENIISENQ MNQIFDDVQN TLRAAHDKID KNDKMDNPDM QKPDSLAEPI 550 560 570 580 590 600 QTKDEEVSYE QLKEINDAML SYPSDFNVLK KLNKVLEKRR EPFESEDGLV DWAQAEQLAF 610 620 630 640 650 660 ATITQNGRPI RLTGQDSERG TFSHRHAVLH DPDTGAQYVP LHNVPDQKAT FEVRNSPLSE 670 680 690 700 710 720 AAVVGFEYGY NIQNKSCMTI WEAQYGDFSN MAQMIFDNFL FSSRAKWGER SGLTLFLPHS 730 740 750 760 770 780 FEGQGPEHSS ARLERFLQLA GENNSTIVNL SSSSNYFHLL RAQAANLGTQ SMRPLVVMSP 790 800 810 820 830 840 KSLLRNKTVA DPISKFTSGK FEPILPEAHD KASVKKVILA SGKMFIDLKE YLTKNPNKSI 850 860 870 880 890 900 LLVAVERLYP FPADEIDALL SELPNLEHVA WVQEEPKNQG AWSFVYPYLK ELTTDKYDLS 910 920 930 YHGRIQRSAP AEGDGEIHKL VQNMIIEQST NIN

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP008934 Genomic DNA. Translation: BAE18470.1.
RefSeq	YP_301415.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3616663.
GenomeReviews	Gene locus SSP1325 in contig AP008934_GR.
KEGG	ssp:SSP1325.
NMPDR	fig|342451.4.peg.605.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q49XM5.
Enzyme and pathway databases
BioCyc	SSAP342451:SSP1325-MON.
Family and domain databases
HAMAP	MF_01169. [Tree]
InterPro	IPR011603. 2oxoglutarate_DHase_E1. IPR001017. DHase_E1. IPR005475. Transketo_Cen_R. [Graphical view]
PANTHER	PTHR23152. 2oxoglutarate_DH_E1. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ODO1_STAS1

Accession

Primary (citable) accession number: Q49XM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	September 13, 2005
Last modified:	November 4, 2008
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)