ID   TYRA_STAS1              Reviewed;         363 AA.
AC   Q49XG5;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 26.
DE   RecName: Full=Prephenate dehydrogenase;
DE            Short=PDH;
DE            EC=1.3.1.12;
GN   Name=tyrA; OrderedLocusNames=SSP1387;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 /
OS   DSM 20229).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K.,
RA   Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S.,
RA   Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- CATALYTIC ACTIVITY: Prephenate + NAD(+) = 4-hydroxyphenylpyruvate
CC       + CO(2) + NADH.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; L-
CC       tyrosine from prephenate: step 1/2.
CC   -!- SIMILARITY: Contains 1 ACT domain.
CC   -!- SIMILARITY: Contains 1 prephenate/arogenate dehydrogenase domain.
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DR   EMBL; AP008934; BAE18532.1; -; Genomic_DNA.
DR   RefSeq; YP_301477.1; -.
DR   GeneID; 3617115; -.
DR   GenomeReviews; AP008934_GR; SSP1387.
DR   KEGG; ssp:SSP1387; -.
DR   NMPDR; fig|342451.4.peg.734; -.
DR   HOGENOM; Q49XG5; -.
DR   OMA; Q49XG5; QRAIRWG.
DR   BioCyc; SSAP342451:SSP1387-MON; -.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0008977; F:prephenate dehydrogenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002912; ACT_bd.
DR   InterPro; IPR003099; Prephen_DH.
DR   PANTHER; PTHR21363; Prephen_DH; 1.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF02153; PDH; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NAD; Oxidoreductase; Tyrosine biosynthesis.
FT   CHAIN         1    363       Prephenate dehydrogenase.
FT                                /FTId=PRO_0000282666.
FT   DOMAIN        2    291       Prephenate/arogenate dehydrogenase.
FT   DOMAIN      295    357       ACT.
FT   NP_BIND       3     33       NAD (Potential).
SQ   SEQUENCE   363 AA;  40963 MW;  130EB5895E8F90DF CRC64;
     MKQILFVGLG LIGGSLASNL RYYHDDIEIT AFDADTSQLD KALSIGIIDY QSTDYKTSVE
     NADIIIYATP VQQTVKYLQD LPNYQLKKHV IITDTGSTKS TIQQYEQFLL NHDIHLVGGH
     PMAGSHKSGV LNAKKHLFEN AFYILVHNET DNDAAFEEIQ HLLQTTSAKF ISTTAEEHDF
     VTGIVSHVPH IIASSLVHLN AQHVEDSSLV KTLAAGGFRD ITRIASSNPI MWRDITIENK
     NTILRILKEW KNQMSDVINI IEHNNPDELY DFFNDAKVYR DQLPLKQQGA LSVEYDLYVD
     IPDKPGMISK VTNILSLHNI SISNLRILEV REDIYGALRV SFKNPQDRKD GADALSDFDT
     YFD
//