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Protein

Prephenate dehydrogenase

Gene

tyrA

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathwayi: L-tyrosine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route).
Proteins known to be involved in this subpathway in this organism are:
  1. Prephenate dehydrogenase (tyrA)
This subpathway is part of the pathway L-tyrosine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route), the pathway L-tyrosine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi3 – 33NADSequence analysisAdd BLAST31

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00122; UER00961.

Names & Taxonomyi

Protein namesi
Recommended name:
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
Ordered Locus Names:SSP1387
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000006371 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002826661 – 363Prephenate dehydrogenaseAdd BLAST363

Interactioni

Protein-protein interaction databases

STRINGi342451.SSP1387.

Structurei

3D structure databases

ProteinModelPortaliQ49XG5.
SMRiQ49XG5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 291Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd BLAST290
Domaini296 – 363ACTPROSITE-ProRule annotationAdd BLAST68

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105EVN. Bacteria.
COG0287. LUCA.
HOGENOMiHOG000043494.
KOiK04517.
OMAiMWRDICL.
OrthoDBiPOG091H02BW.

Family and domain databases

InterProiView protein in InterPro
IPR008927. 6-PGluconate_DH-like_C_sf.
IPR002912. ACT_dom.
IPR036291. NAD(P)-bd_dom_sf.
IPR003099. Prephen_DH.
PfamiView protein in Pfam
PF01842. ACT. 1 hit.
PF02153. PDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q49XG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQILFVGLG LIGGSLASNL RYYHDDIEIT AFDADTSQLD KALSIGIIDY
60 70 80 90 100
QSTDYKTSVE NADIIIYATP VQQTVKYLQD LPNYQLKKHV IITDTGSTKS
110 120 130 140 150
TIQQYEQFLL NHDIHLVGGH PMAGSHKSGV LNAKKHLFEN AFYILVHNET
160 170 180 190 200
DNDAAFEEIQ HLLQTTSAKF ISTTAEEHDF VTGIVSHVPH IIASSLVHLN
210 220 230 240 250
AQHVEDSSLV KTLAAGGFRD ITRIASSNPI MWRDITIENK NTILRILKEW
260 270 280 290 300
KNQMSDVINI IEHNNPDELY DFFNDAKVYR DQLPLKQQGA LSVEYDLYVD
310 320 330 340 350
IPDKPGMISK VTNILSLHNI SISNLRILEV REDIYGALRV SFKNPQDRKD
360
GADALSDFDT YFD
Length:363
Mass (Da):40,963
Last modified:September 13, 2005 - v1
Checksum:i130EB5895E8F90DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA. Translation: BAE18532.1.
RefSeqiWP_002483353.1. NZ_MTGA01000038.1.

Genome annotation databases

EnsemblBacteriaiBAE18532; BAE18532; SSP1387.
GeneIDi3617115.
KEGGissp:SSP1387.

Similar proteinsi

Entry informationi

Entry nameiTYRA_STAS1
AccessioniPrimary (citable) accession number: Q49XG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 13, 2005
Last modified: November 22, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families