Q49XG5 (TYRA_STAS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Prephenate dehydrogenase
Short name=PDH
EC=1.3.1.12

Gene names

Name:	tyrA
Ordered Locus Names:	SSP1387

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus saprophyticus › Staphylococcus saprophyticus subsp. saprophyticus

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.
Pathway	Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.
Sequence similarities	Contains 1 ACT domain. Contains 1 prephenate/arogenate dehydrogenase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tyrosine biosynthesis
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tyrosine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	amino acid binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro prephenate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro prephenate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	Prephenate dehydrogenase		PRO_0000282666
Regions
	Domain	2 – 291	290	Prephenate/arogenate dehydrogenase
	Domain	295 – 357	63	ACT
	Nucleotide binding	3 – 33	31	NAD Potential

Sequences

	Sequence		Length	Mass (Da)
	Q49XG5 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 130EB5895E8F90DF	FASTA	363	40,963
	10 20 30 40 50 60 MKQILFVGLG LIGGSLASNL RYYHDDIEIT AFDADTSQLD KALSIGIIDY QSTDYKTSVE 70 80 90 100 110 120 NADIIIYATP VQQTVKYLQD LPNYQLKKHV IITDTGSTKS TIQQYEQFLL NHDIHLVGGH 130 140 150 160 170 180 PMAGSHKSGV LNAKKHLFEN AFYILVHNET DNDAAFEEIQ HLLQTTSAKF ISTTAEEHDF 190 200 210 220 230 240 VTGIVSHVPH IIASSLVHLN AQHVEDSSLV KTLAAGGFRD ITRIASSNPI MWRDITIENK 250 260 270 280 290 300 NTILRILKEW KNQMSDVINI IEHNNPDELY DFFNDAKVYR DQLPLKQQGA LSVEYDLYVD 310 320 330 340 350 360 IPDKPGMISK VTNILSLHNI SISNLRILEV REDIYGALRV SFKNPQDRKD GADALSDFDT YFD

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15305 / DSM 20229.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008934 Genomic DNA. Translation: BAE18532.1.
RefSeq	YP_301477.1. NC_007350.1.
3D structure databases
HSSP	HSSP built from PDB template 2G5C based on UniProtKB O67636.
ProteinModelPortal	Q49XG5.
ModBase	Search...
Protein-protein interaction databases
STRING	342451.SSP1387.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAE18532; BAE18532; SSP1387.
GeneID	3617115.
KEGG	ssp:SSP1387.
PATRIC	19624364. VBIStaSap90642_1389.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0287.
HOGENOM	HOG000043494.
KO	K04517.
OMA	QRAIRWG.
ProtClustDB	PRK06545.
Enzyme and pathway databases
UniPathway	UPA00122; UER00961.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR002912. ACT_dom. IPR016040. NAD(P)-bd_dom. IPR003099. Prephen_DH. [Graphical view]
Pfam	PF01842. ACT. 1 hit. PF02153. PDH. 1 hit. [Graphical view]
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS51176. PDH_ADH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYRA_STAS1

Accession

Primary (citable) accession number: Q49XG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	September 13, 2005
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program