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Reviewed, UniProtKB/Swiss-Prot Q49XG5 (TYRA_STAS1)

Last modified June 16, 2009. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Prephenate dehydrogenase
      Short name=PDH
    EC=1.3.1.12
Gene names
Name: tyrA
Ordered Locus Names: SSP1387
OrganismStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]
Taxonomic identifier342451 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesStaphylococcus

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existencePredicted.

General annotation (Comments)

Catalytic activity

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathway

Amino-acid biosynthesis; L-tyrosine biosynthesis; L-tyrosine from prephenate: step 1/2.

Sequence similarities

Contains 1 ACT domain.

Contains 1 prephenate/arogenate dehydrogenase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Prephenate dehydrogenase
PRO_0000282666

Regions

Domain2 – 291290Prephenate/arogenate dehydrogenase
Domain295 – 35763ACT
Nucleotide binding3 – 3331NAD Potential

Sequences

Sequence LengthMass (Da)Tools
Q49XG5-1 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 130EB5895E8F90DF

FASTA36340,963
        10         20         30         40         50         60 
MKQILFVGLG LIGGSLASNL RYYHDDIEIT AFDADTSQLD KALSIGIIDY QSTDYKTSVE 

        70         80         90        100        110        120 
NADIIIYATP VQQTVKYLQD LPNYQLKKHV IITDTGSTKS TIQQYEQFLL NHDIHLVGGH 

       130        140        150        160        170        180 
PMAGSHKSGV LNAKKHLFEN AFYILVHNET DNDAAFEEIQ HLLQTTSAKF ISTTAEEHDF 

       190        200        210        220        230        240 
VTGIVSHVPH IIASSLVHLN AQHVEDSSLV KTLAAGGFRD ITRIASSNPI MWRDITIENK 

       250        260        270        280        290        300 
NTILRILKEW KNQMSDVINI IEHNNPDELY DFFNDAKVYR DQLPLKQQGA LSVEYDLYVD 

       310        320        330        340        350        360 
IPDKPGMISK VTNILSLHNI SISNLRILEV REDIYGALRV SFKNPQDRKD GADALSDFDT 


YFD 

« Hide

References

[1]"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

AP008934 Genomic DNA. Translation: BAE18532.1.
RefSeqYP_301477.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3617115.
GenomeReviewsGene locus SSP1387 in contig AP008934_GR.
KEGGssp:SSP1387.
NMPDRfig|342451.4.peg.734.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ49XG5.
OMAQ49XG5. QRAIRWG.

Enzyme and pathway databases

BioCycSSAP342451:SSP1387-MON.

Family and domain databases

InterProIPR002912. ACT_bd.
IPR003099. Prephen_DH.
[Graphical view]
PANTHERPTHR21363. Prephen_DH. 1 hit.
PfamPF01842. ACT. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view]
PROSITEPS51176. PDH_ADH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYRA_STAS1
AccessionPrimary (citable) accession number: Q49XG5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 13, 2005
Last modified: June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents