Q49XE2 (MSCL_STAS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Large-conductance mechanosensitive channel

Gene names

Name:	mscL
Ordered Locus Names:	SSP1410

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity. HAMAP MF_00115
Subunit structure	Homopentamer By similarity. HAMAP MF_00115
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_00115.
Sequence similarities	Belongs to the MscL family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Ionic channel
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 117	117	Large-conductance mechanosensitive channel HAMAP MF_00115		PRO_0000238041
Regions
	Transmembrane	7 – 27	21	Helical; Potential
	Transmembrane	30 – 50	21	Helical; Potential
	Transmembrane	64 – 84	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q49XE2 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: B701AA9597A8E1B3	FASTA	117	13,275
	10 20 30 40 50 60 MLKEFKEFAL KGNVLDLAVA VVMGAAFNKI VTALVSYIIM PLIGLIFGTV DFAESWSFMG 70 80 90 100 110 IKYGMFVQSI IDFIIIAFAL FIFVKIANTL MKKEEEEEIE ENTVLLTEIR DLLREKN

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15305 / DSM 20229.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008934 Genomic DNA. Translation: BAE18555.1.
RefSeq	YP_301500.1. NC_007350.1.
3D structure databases
ProteinModelPortal	Q49XE2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q49XE2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000048698; EBSTAP00000047067; EBSTAG00000048695.
GeneID	3615349.
GenomeReviews	Gene locus SSP1410 in contig AP008934_GR.
KEGG	ssp:SSP1410.
NMPDR	fig|342451.4.peg.765.
PATRIC	19624412. VBIStaSap90642_1413.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1970.
GeneTree	EBGT00050000025511.
HOGENOM	HBG727604.
OMA	VIDFVIV.
PhylomeDB	Q49XE2.
ProtClustDB	PRK13954.
Enzyme and pathway databases
BioCyc	SSAP342451:SSP1410-MONOMER.
Family and domain databases
HAMAP	MF_00115. MscL. [Tree]
InterPro	IPR019823. Mechanosensitive_channel_CS. IPR001185. MS_channel. [Graphical view]
KO	K03282.
Pfam	PF01741. MscL. 1 hit. [Graphical view]
PRINTS	PR01264. MECHCHANNEL.
SUPFAM	SSF81330. MS_channel. 1 hit.
TIGRFAMs	TIGR00220. MscL. 1 hit.
PROSITE	PS01327. MSCL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MSCL_STAS1

Accession

Primary (citable) accession number: Q49XE2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program