Reviewed, UniProtKB/Swiss-Prot Q49X94 (GLPD_STAS1)

Names and origin

Protein names

Recommended name:
    Aerobic glycerol-3-phosphate dehydrogenase
    EC=1.1.5.3

Gene names

Name:	glpD
Ordered Locus Names:	SSP1459

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	557 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.
Cofactor	FAD By similarity.
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (aerobic route): step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	glycerol-3-phosphate dehydrogenase complex Inferred from electronic annotation. Source: InterPro
Molecular function	glycerol-3-phosphate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 557	557	Aerobic glycerol-3-phosphate dehydrogenase		PRO_0000270068
Regions
	Nucleotide binding	21 – 49	29	FAD Potential

Sequences

	Sequence		Length	Mass (Da)
	Q49X94-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 519E5CAF87EC8989	FASTA	557	62,260
	10 20 30 40 50 60 MSLSTLKREQ IKKDLKDQEF DVVIIGGGIT GAGIALDASE RGMKVALVEM QDFAQGTSSR 70 80 90 100 110 120 STKLVHGGLR YLKQLQVGVV AETGRERAIV YENGPHVTTP ERMLLPMHKG GSMGKFTTSI 130 140 150 160 170 180 GLAMYDRLAG VKKAERKTML NAKETLEKEP LVKKAGLKGG GSYVEYRTDD ARLTIEVMKR 190 200 210 220 230 240 AEEKGAKVIN HTKSVHFTYD SNEKVNGIQV EDQISNETYP IKAKKVINAS GPWVDEVRSG 250 260 270 280 290 300 DYARNNKQLR LTKGVHIVID QSKFPLGQAV YFDTEKDGRM IFAIPREGKA YVGTTDTFYD 310 320 330 340 350 360 NNKTSPLANQ EDRDYLIDAI NYMFPDVNVA DEDIESSWAG VRPLILEEGK DPSEISRKDE 370 380 390 400 410 420 VWEGKSGLLT IAGGKLTGYR HMALEIVDLL SKRLKSEFGL KFDKCATKHL TISGGDVGGS 430 440 450 460 470 480 ANFDKFIEQK VEEAKSYQID ESTARHFASK YGSNAEELFK IAQTAQYQET GLPLDIYTEL 490 500 510 520 530 540 VYSIQNEMVY RPTDFFIRRT GKLYFKIDDV LNYKEQVIDV MAGLLGYTNI EKEAYTKELQ 550 IAIDEAQTGN HQPAVKE

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP008934 Genomic DNA. Translation: BAE18604.1.
RefSeq	YP_301549.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3615086.
GenomeReviews	Gene locus SSP1459 in contig AP008934_GR.
KEGG	ssp:SSP1459.
NMPDR	fig|342451.4.peg.902.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q49X94.
OMA	Q49X94. KDIESSW.
Enzyme and pathway databases
BioCyc	SSAP342451:SSP1459-MON.
Family and domain databases
InterPro	IPR000447. FAD-dep_Gly3P_DH. IPR006076. FAD-dep_OxRdtase. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
PRINTS	PR01001. FADG3PDH.
PROSITE	PS00977. FAD_G3PDH_1. 1 hit. PS00978. FAD_G3PDH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPD_STAS1

Accession

Primary (citable) accession number: Q49X94

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)