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Reviewed, UniProtKB/Swiss-Prot Q49X46 (CDSA_STAS1)

Last modified February 9, 2010. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Phosphatidate cytidylyltransferase
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthase
    CDP-diacylglycerol synthase
      Short name=CDS
    CTP:phosphatidate cytidylyltransferase
    CDP-DG synthase
    CDP-DAG synthase
Gene names
Name: cdsA
Ordered Locus Names: SSP1507
OrganismStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]
Taxonomic identifier342451 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesStaphylococcus

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathway

Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the CDS family.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionphosphatidate cytidylyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 260260Phosphatidate cytidylyltransferase
PRO_0000090756

Regions

Transmembrane9 – 2921 Potential
Transmembrane46 – 6621 Potential
Transmembrane70 – 9021 Potential
Transmembrane102 – 12221 Potential
Transmembrane130 – 15021 Potential
Transmembrane172 – 19221 Potential
Transmembrane196 – 21621 Potential

Sequences

Sequence LengthMass (Da)Tools
Q49X46-1 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: C95166CECD1011F0

FASTA26029,066
        10         20         30         40         50         60 
MKVRTLTAII ALIVFLPVLL KGGLILMLFS YLLAFIALKE LLNMNMIKFL SIPGIISALG 

        70         80         90        100        110        120 
ILIIMLPQDA GSWVNDLQLK SLIAMSFILL SYTVLSKNRF SFMDAAFCLM SIAYVGIGFM 

       130        140        150        160        170        180 
YLYETRSEGL HYILFAFLVV WLTDTGAYIF GRLMGKHKLW PVISPNKTVE GFVGGLICSL 

       190        200        210        220        230        240 
IVPLVMMIFV DFNIALWLLL IITIILSMFG QLGDLVESGF KRHFGVKDSG RILPGHGGIL 

       250        260 
DRFDSFMFVL PLLNILLIQI 

« Hide

References

[1]"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008934 Genomic DNA. Translation: BAE18652.1.
RefSeqYP_301597.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ49X46.

Genome annotation databases

GeneID3617249.
GenomeReviewsGene locus SSP1507 in contig AP008934_GR.
KEGGssp:SSP1507.
NMPDRfig|342451.4.peg.1523.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0575.
HOGENOMHBG732679.
OMAMRERFIW.

Enzyme and pathway databases

BioCycSSAP342451:SSP1507-MONOMER.

Family and domain databases

InterProIPR000374. PC_trans.
[Graphical view]
PfamPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDSA_STAS1
AccessionPrimary (citable) accession number: Q49X46
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: September 13, 2005
Last modified: February 9, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents