Q49WY1 (PYRB_STAS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	SSP1572

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 300	300	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000301626

Sequences

	Sequence		Length	Mass (Da)
	Q49WY1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 83996163653D0C1E	FASTA	300	34,032
	10 20 30 40 50 60 MDNLLSTEYL NTTEIYDLIQ RASAFKNGNA QPGCFEDKFV ANLFFENSTR TKSSFLVAEQ 70 80 90 100 110 120 KLGLKLIDFE TSTSSVQKGE SLYDTCKTLE QIGANVLVIR HSQTTYYDEL KHLNIPIINA 130 140 150 160 170 180 GDGSGQHPTQ SLLDLMTIYE EYKTFEGLNV LICGDVKNSR VAKSNYQSLT ALGAHVMFSS 190 200 210 220 230 240 PDEWKDETLE APYVDIDEVI DRIDIVMLLR VQHERHEDSE VTSFEVSQYH ENFGLTQSRY 250 260 270 280 290 300 DLLKDRAIIM HPAPVNRGVE IEDTLVEAPK SRIFKQMENG MYIRMAVIDH ILQTEGATAK

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15305 / DSM 20229.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008934 Genomic DNA. Translation: BAE18717.1.
RefSeq	YP_301662.1. NC_007350.1.
3D structure databases
HSSP	HSSP built from PDB template 2AIR based on UniProtKB P0A786.
ProteinModelPortal	Q49WY1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q49WY1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000047982; EBSTAP00000046351; EBSTAG00000047979.
GeneID	3615316.
GenomeReviews	Gene locus SSP1572 in contig AP008934_GR.
KEGG	ssp:SSP1572.
NMPDR	fig|342451.4.peg.1587.
PATRIC	19624734. VBIStaSap90642_1574.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
GeneTree	EBGT00050000023906.
HOGENOM	HBG579429.
OMA	VGIPIIN.
PhylomeDB	Q49WY1.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	SSAP342451:SSP1572-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_STAS1

Accession

Primary (citable) accession number: Q49WY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program