ID   PGCA_STAS1              Reviewed;         552 AA.
AC   Q49WH7;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Phosphoglucomutase;
DE            Short=PGM;
DE            EC=5.4.2.2;
DE   AltName: Full=Alpha-phosphoglucomutase;
DE   AltName: Full=Glucose phosphomutase;
GN   Name=pgcA; OrderedLocusNames=SSP1737;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 /
OS   DSM 20229).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K.,
RA   Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S.,
RA   Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- FUNCTION: Catalyzes the interconversion between glucose-6-
CC       phosphate and alpha-glucose-1-phosphate. This is the first step in
CC       the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. a
CC       glycolipid found in the membrane, which is also used as a membrane
CC       anchor for lipoteichoic acid (LTA) (By similarity).
CC   -!- CATALYTIC ACTIVITY: Alpha-D-glucose 1-phosphate = alpha-D-glucose
CC       6-phosphate.
CC   -!- COFACTOR: Binds 1 magnesium ion per subunit (By similarity).
CC   -!- PATHWAY: Glycolipid metabolism; diglucosyl-diacylglycerol
CC       biosynthesis.
CC   -!- SIMILARITY: Belongs to the phosphohexose mutase family.
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DR   EMBL; AP008934; BAE18882.1; -; Genomic_DNA.
DR   RefSeq; YP_301827.1; -.
DR   GeneID; 3616646; -.
DR   GenomeReviews; AP008934_GR; SSP1737.
DR   KEGG; ssp:SSP1737; -.
DR   NMPDR; fig|342451.4.peg.1790; -.
DR   HOGENOM; Q49WH7; -.
DR   OMA; Q49WH7; IGEDVDM.
DR   BioCyc; SSAP342451:SSP1737-MON; -.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004614; F:phosphoglucomutase activity; IEA:EC.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005844; A-D-PHexomutase_a/b/a-I.
DR   InterPro; IPR016055; A-D-PHexomutase_a/b/a-I/II/III.
DR   InterPro; IPR005845; A-D-PHexomutase_a/b/a-II.
DR   InterPro; IPR005843; A-D-PHexomutase_C.
DR   InterPro; IPR016066; A-D-PHexomutase_CS.
DR   InterPro; IPR005841; A-D-PHexomutase_N.
DR   Gene3D; G3DSA:3.40.120.10; A-D-PHexomutase_a/b/a-I/II/III; 3.
DR   Pfam; PF02878; PGM_PMM_I; 1.
DR   Pfam; PF02879; PGM_PMM_II; 1.
DR   Pfam; PF00408; PGM_PMM_IV; 1.
DR   PRINTS; PR00509; PGMPMM.
DR   PROSITE; PS00710; PGM_PMM; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Glucose metabolism;
KW   Isomerase; Magnesium; Metal-binding; Phosphoprotein.
FT   CHAIN         1    552       Phosphoglucomutase.
FT                                /FTId=PRO_0000308348.
FT   ACT_SITE    135    135       Phosphoserine intermediate (By
FT                                similarity).
FT   METAL       135    135       Magnesium; via phosphate group (By
FT                                similarity).
FT   METAL       289    289       Magnesium (By similarity).
FT   METAL       291    291       Magnesium (By similarity).
FT   METAL       293    293       Magnesium (By similarity).
SQ   SEQUENCE   552 AA;  62077 MW;  886FB7BAE51C97DF CRC64;
     MKALWLENIN ESLVKDFYET QTEEEQNAGF EGVLSFGTAG IRSTFGLGPA RLNAFTVRKV
     ALGLAQYLNH NVDDASVVIH FDTRFLSKAF SQEMASVLAN NGITAIISDN YKSTPELSFA
     VRHLQVNAGI MITASHNPKN YNGIKIYNEK GGQLLPEASE QLSEYINSIE TPLNIEKGDF
     NAFVENGKIK YMSNEVTESY KKEVKSLVGS IDAHDAKVIL TSLHGTSLPL VSDILTELDY
     HNFVIEKEQS EPNGNFPTVA IANPEDEAAF TLGKQLADKT DAQLIIATDP DADRLGFIER
     YGDNDFRYFN GNEIGLLLMK LRFQDLTEDS TPQYMIKSIV TSELAERLAT SLNVEVNDVL
     TGFKFISDLI EHKQKDDDKQ LLLAFEESHG YLAQPISRDK DAIQMVPLLV KYKNLLDKNG
     ITFKETIEDI YENIGYFKDR TLAPTFEGKA GVKKIESIMS QFRNEQVFSI CGMDVLKIED
     YHVGEVRDMI TGHTEKLTLP KTNLIRFIFE NGFIALRPSG TEPKIKLYFS LEVENIDEIT
     QQFEANYINN IV
//