Reviewed, UniProtKB/Swiss-Prot Q49WH7 (PGCA_STAS1)

Names and origin

Protein names

Recommended name:
    Phosphoglucomutase
      Short name=PGM
    EC=5.4.2.2
Alternative name(s):
    Alpha-phosphoglucomutase
    Glucose phosphomutase

Gene names

Name:	pgcA
Ordered Locus Names:	SSP1737

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	552 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the interconversion between glucose-6-phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. a glycolipid found in the membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) By similarity.
Catalytic activity	Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Pathway	Glycolipid metabolism; diglucosyl-diacylglycerol biosynthesis.
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglucomutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 552	552	Phosphoglucomutase		PRO_0000308348
Sites
	Active site	135	1	Phosphoserine intermediate By similarity
	Metal binding	135	1	Magnesium; via phosphate group By similarity
	Metal binding	289	1	Magnesium By similarity
	Metal binding	291	1	Magnesium By similarity
	Metal binding	293	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q49WH7-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 886FB7BAE51C97DF	FASTA	552	62,077
	10 20 30 40 50 60 MKALWLENIN ESLVKDFYET QTEEEQNAGF EGVLSFGTAG IRSTFGLGPA RLNAFTVRKV 70 80 90 100 110 120 ALGLAQYLNH NVDDASVVIH FDTRFLSKAF SQEMASVLAN NGITAIISDN YKSTPELSFA 130 140 150 160 170 180 VRHLQVNAGI MITASHNPKN YNGIKIYNEK GGQLLPEASE QLSEYINSIE TPLNIEKGDF 190 200 210 220 230 240 NAFVENGKIK YMSNEVTESY KKEVKSLVGS IDAHDAKVIL TSLHGTSLPL VSDILTELDY 250 260 270 280 290 300 HNFVIEKEQS EPNGNFPTVA IANPEDEAAF TLGKQLADKT DAQLIIATDP DADRLGFIER 310 320 330 340 350 360 YGDNDFRYFN GNEIGLLLMK LRFQDLTEDS TPQYMIKSIV TSELAERLAT SLNVEVNDVL 370 380 390 400 410 420 TGFKFISDLI EHKQKDDDKQ LLLAFEESHG YLAQPISRDK DAIQMVPLLV KYKNLLDKNG 430 440 450 460 470 480 ITFKETIEDI YENIGYFKDR TLAPTFEGKA GVKKIESIMS QFRNEQVFSI CGMDVLKIED 490 500 510 520 530 540 YHVGEVRDMI TGHTEKLTLP KTNLIRFIFE NGFIALRPSG TEPKIKLYFS LEVENIDEIT 550 QQFEANYINN IV

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008934 Genomic DNA. Translation: BAE18882.1.
RefSeq	YP_301827.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q49WH7.
Genome annotation databases
GeneID	3616646.
GenomeReviews	Gene locus SSP1737 in contig AP008934_GR.
KEGG	ssp:SSP1737.
NMPDR	fig|342451.4.peg.1790.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1109.
HOGENOM	HBG571743.
OMA	IGEDVDM.
PhylomeDB	Q49WH7.
Enzyme and pathway databases
BioCyc	SSAP342451:SSP1737-MONOMER.
Family and domain databases
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. A-D-PHexomutase_N. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGCA_STAS1

Accession

Primary (citable) accession number: Q49WH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	September 13, 2005
Last modified:	January 19, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)