Q49WD6 (PPNK_STAS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase
Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	SSP1778

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_0000120667

Sequences

	Sequence		Length	Mass (Da)
	Q49WD6 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 8744737BFF6E6F92	FASTA	269	30,457
	10 20 30 40 50 60 MRYTILSKGD SKSNALKHKM INHMKDFQMV EDPDNPEIVI SVGGDGTLLQ AFHQYSYMLS 70 80 90 100 110 120 RCAFVGIHTG HLGFYADWLP HEVEKLIIEI NNSEFQVIEY PLLEIIVRYN DNGYETRHLA 130 140 150 160 170 180 LNEATMKTEN GSTLVVDVNI RGNQFERFRG DGLCISTPSG STAYNKALGG ALIHPSLEAM 190 200 210 220 230 240 QIAEIASINN RVFRTVGSPL VLPKHHTCLI TPVNQDTILT TIDHVSIKHK NVNAIQYRVA 250 260 NEKIRFARFR PFPFWKRVHD SFISSGDDE

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15305 / DSM 20229.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008934 Genomic DNA. Translation: BAE18923.1.
RefSeq	YP_301868.1. NC_007350.1.
3D structure databases
ProteinModelPortal	Q49WD6.
SMR	Q49WD6. Positions 1-264.
ModBase	Search...
Protein-protein interaction databases
STRING	Q49WD6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000048084; EBSTAP00000046453; EBSTAG00000048081.
GeneID	3615405.
GenomeReviews	Gene locus SSP1778 in contig AP008934_GR.
KEGG	ssp:SSP1778.
NMPDR	fig|342451.4.peg.1650.
PATRIC	19625141. VBIStaSap90642_1774.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0061.
GeneTree	EBGT00050000025514.
HOGENOM	HBG314020.
OMA	TISFANC.
PhylomeDB	Q49WD6.
ProtClustDB	PRK04885.
Enzyme and pathway databases
BioCyc	SSAP342451:SSP1778-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK_STAS1

Accession

Primary (citable) accession number: Q49WD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program