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Q49WA0

- ASSY_STAS1

UniProt

Q49WA0 - ASSY_STAS1

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851CitrullineUniRule annotation
Binding sitei115 – 1151ATP; via amide nitrogenUniRule annotation
Binding sitei117 – 1171AspartateUniRule annotation
Binding sitei121 – 1211AspartateUniRule annotation
Binding sitei121 – 1211CitrullineUniRule annotation
Binding sitei122 – 1221AspartateUniRule annotation
Binding sitei125 – 1251CitrullineUniRule annotation
Binding sitei173 – 1731CitrullineUniRule annotation
Binding sitei182 – 1821CitrullineUniRule annotation
Binding sitei258 – 2581CitrullineUniRule annotation
Binding sitei270 – 2701CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 169ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSAP342451:GKFA-1876-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:SSP1814
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000006371: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Argininosuccinate synthasePRO_0000263979Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi342451.SSP1814.

Structurei

3D structure databases

ProteinModelPortaliQ49WA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49WA0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKEKIVLAYS GGLDTSVAVK WLLDKGYDVV ACCLDVGEGK DLELVHQKAL
60 70 80 90 100
DMGAIECHII DATEEFSQDY VSYAIKGNLM YEGTYPLVSA LSRPLISKKL
110 120 130 140 150
VEIASKTNSV GIAHGCTGKG NDQVRFEVAI KALDPELKVF APVREWAWSR
160 170 180 190 200
EEEIDYAIKH NIPVPIQHDS PYSIDQNLWG RSNECGILED PYATPPKDAY
210 220 230 240 250
DLTNELEDAP DEAEEIVLSF EKGIPVSLDG TAYKLSELIL ELNKLAGKHG
260 270 280 290 300
VGRIDHVENR LVGIKSREVY ETPAAEVIMN AHKALETITL TKDVAHFKPV
310 320 330 340 350
IEKQFSEQIY NGLWFSPLTD SLKIFVDSTQ AHVTGDVRLK LYKGNAIVNG
360 370 380 390 400
RQSPYTLYNE KLATYTKEDA FNQESAVGFI DIFGLPTKVN SMLHGGYKDE

Q
Length:401
Mass (Da):44,587
Last modified:September 13, 2005 - v1
Checksum:i35BBD7E4E9F2956F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE18959.1.
RefSeqiWP_011303509.1. NC_007350.1.
YP_301904.1. NC_007350.1.

Genome annotation databases

EnsemblBacteriaiBAE18959; BAE18959; SSP1814.
GeneIDi3616469.
KEGGissp:SSP1814.
PATRICi19625213. VBIStaSap90642_1810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE18959.1 .
RefSeqi WP_011303509.1. NC_007350.1.
YP_301904.1. NC_007350.1.

3D structure databases

ProteinModelPortali Q49WA0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 342451.SSP1814.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE18959 ; BAE18959 ; SSP1814 .
GeneIDi 3616469.
KEGGi ssp:SSP1814.
PATRICi 19625213. VBIStaSap90642_1810.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci SSAP342451:GKFA-1876-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
    Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
    Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15305 / DSM 20229.

Entry informationi

Entry nameiASSY_STAS1
AccessioniPrimary (citable) accession number: Q49WA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 13, 2005
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3