Q49W96 (OAT2_STAS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine aminotransferase 2
Short name=OAT 2
EC=2.6.1.13

Alternative name(s):
Ornithine--oxo-acid aminotransferase 2

Gene names

Name:	rocD2
Ordered Locus Names:	SSP1818

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of ornithine to glutamate semialdehyde By similarity. HAMAP MF_01689
Catalytic activity	L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid. HAMAP MF_01689
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01689
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1. HAMAP MF_01689
Subcellular location	Cytoplasm By similarity HAMAP MF_01689.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: InterPro proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ornithine-oxo-acid transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	Ornithine aminotransferase 2 HAMAP MF_01689		PRO_0000112797
Amino acid modifications
	Modified residue	255	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q49W96 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 02BC20FA8B3FEE43	FASTA	396	43,399
	10 20 30 40 50 60 MSRSEEIIEV TNHYGAQNYV PLPIVISEAE GVWVKDPEGN KYMDMLSAYS AVNQGHRHPK 70 80 90 100 110 120 IIQALKEQAD KVTLVSRAFH SENLGEWYEK ICKLSGKAKA LPMNTGAEAV ETALKAARRW 130 140 150 160 170 180 AYDVKNIQPD KAEIIAFNGN FHGRTMAPVS LSSEPEYQRG YGPLLDGFRK VDFGDIEAVK 190 200 210 220 230 240 AAINENTAAI LIEPIQGEAG INVPPEGYLK QIRELCDEHN VLFIADEIQA GLGRSGKLFA 250 260 270 280 290 300 TDWDNVKPDV YILGKALGGG VLPISVVLAD EEVLGVFTPG SHGSTFGGNP LACAVSNAAL 310 320 330 340 350 360 DVIIDEDLPG RSLELGDYFK SELEKIDHPA IKEVRGRGLF IGIELNEAAR PFCESLKEQG 370 380 390 LLCKETHDTV IRFAPPLIIS KEELDFALDK VRSVFE

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15305 / DSM 20229.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008934 Genomic DNA. Translation: BAE18963.1.
RefSeq	YP_301908.1. NC_007350.1.
3D structure databases
ProteinModelPortal	Q49W96.
ModBase	Search...
Protein-protein interaction databases
STRING	Q49W96.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000049094; EBSTAP00000047463; EBSTAG00000049091.
GeneID	3616473.
GenomeReviews	Gene locus SSP1818 in contig AP008934_GR.
KEGG	ssp:SSP1818.
NMPDR	fig|342451.4.peg.1890.
PATRIC	19625221. VBIStaSap90642_1814.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4992.
GeneTree	EBGT00050000024123.
HOGENOM	HBG725944.
OMA	CHPKILE.
PhylomeDB	Q49W96.
ProtClustDB	PRK04073.
Enzyme and pathway databases
BioCyc	SSAP342451:SSP1818-MONOMER.
Family and domain databases
HAMAP	MF_01689. Ornith_aminotrans_3. [Tree]
InterPro	IPR004636. AcOrn/SuccinylOrn_aminoTrfase. IPR005814. Aminotrans_3. IPR010164. Orn_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
KO	K00819.
PANTHER	PTHR11986. Aminotrans_3. 1 hit. PTHR11986:SF18. Orn_aminotrans. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01885. Orn_aminotrans. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OAT2_STAS1

Accession

Primary (citable) accession number: Q49W96

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program