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Q49W02

- GPMI_STAS1

UniProt

Q49W02 - GPMI_STAS1

Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

gpmI

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

    Catalytic activityi

    2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

    Cofactori

    Binds 2 manganese ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi12 – 121Manganese 2UniRule annotation
    Active sitei62 – 621Phosphoserine intermediateUniRule annotation
    Metal bindingi62 – 621Manganese 2UniRule annotation
    Metal bindingi397 – 3971Manganese 1UniRule annotation
    Metal bindingi401 – 4011Manganese 1UniRule annotation
    Metal bindingi438 – 4381Manganese 2UniRule annotation
    Metal bindingi439 – 4391Manganese 2UniRule annotation
    Metal bindingi456 – 4561Manganese 1UniRule annotation

    GO - Molecular functioni

    1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glucose catabolic process Source: InterPro
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciSSAP342451:GKFA-1976-MONOMER.
    UniPathwayiUPA00109; UER00186.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2,3-bisphosphoglycerate-independent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.12UniRule annotation)
    Short name:
    BPG-independent PGAMUniRule annotation
    Short name:
    PhosphoglyceromutaseUniRule annotation
    Short name:
    iPGMUniRule annotation
    Gene namesi
    Name:gpmIUniRule annotation
    Ordered Locus Names:SSP1913
    OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
    Taxonomic identifieri342451 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000006371: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5055052,3-bisphosphoglycerate-independent phosphoglycerate mutasePRO_0000212216Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi342451.SSP1913.

    Structurei

    3D structure databases

    ProteinModelPortaliQ49W02.
    SMRiQ49W02. Positions 2-503.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BPG-independent phosphoglycerate mutase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0696.
    HOGENOMiHOG000223664.
    KOiK15633.
    OMAiIENYMQE.
    OrthoDBiEOG6HJ22X.

    Family and domain databases

    Gene3Di3.40.1450.10. 1 hit.
    3.40.720.10. 2 hits.
    HAMAPiMF_01038. GpmI.
    InterProiIPR017849. Alkaline_Pase-like_a/b/a.
    IPR017850. Alkaline_phosphatase_core.
    IPR011258. BPG-indep_PGM_N.
    IPR006124. Metalloenzyme.
    IPR005995. Pgm_bpd_ind.
    [Graphical view]
    PfamiPF06415. iPGM_N. 1 hit.
    PF01676. Metalloenzyme. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001492. IPGAM. 1 hit.
    SUPFAMiSSF53649. SSF53649. 2 hits.
    SSF64158. SSF64158. 1 hit.
    TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q49W02-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKQPTALII LDGFANRESE HGNAVKLANK PNFDRYYSKY PTTQIEASGL    50
    DVGLPEGQMG NSEVGHMNIG AGRVVYQSLT RINKSIEDGD FFENDVLNNA 100
    INHVKKNDSV LHVFGLLSDG GVHSHYKHLF ALLDLAKKQG LEKVYVHAFL 150
    DGRDVDQKSA LKYIEETEAK FKELGIGQFA SVSGRYYAMD RDKRWDREEK 200
    AYNAIRNFGG TTFESAKAGV EANYDKDLTD EFVEPFIVQD QNEGVNDGDA 250
    VIFYNFRPDR AGQLSEIFTD KAFEGFKVEQ INDLFYATFT KYNDNVNAEI 300
    VFEKVDLTNT IGEVAQDNGL KQLRIAETEK FPHVTYFMSG GRNEEFEGER 350
    RRLIDSPKVA TYDLKPEMSA YEVKDALIEE LNKGDLDLIL LNFANPDMVG 400
    HSGMLEPTIK AIEAVDECLG EVVDKITEMG GHAIITADHG NSDMVLTDDD 450
    QPMTTHTTNP VPVIVTKDGV TLRETGRLGD LAPTLLDLLN VDQPEDMTGE 500
    SLINH 505
    Length:505
    Mass (Da):56,343
    Last modified:September 13, 2005 - v1
    Checksum:i11E64347EBC3B1AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008934 Genomic DNA. Translation: BAE19058.1.
    RefSeqiYP_302003.1. NC_007350.1.

    Genome annotation databases

    EnsemblBacteriaiBAE19058; BAE19058; SSP1913.
    GeneIDi3615267.
    KEGGissp:SSP1913.
    PATRICi19625407. VBIStaSap90642_1907.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008934 Genomic DNA. Translation: BAE19058.1 .
    RefSeqi YP_302003.1. NC_007350.1.

    3D structure databases

    ProteinModelPortali Q49W02.
    SMRi Q49W02. Positions 2-503.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 342451.SSP1913.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE19058 ; BAE19058 ; SSP1913 .
    GeneIDi 3615267.
    KEGGi ssp:SSP1913.
    PATRICi 19625407. VBIStaSap90642_1907.

    Phylogenomic databases

    eggNOGi COG0696.
    HOGENOMi HOG000223664.
    KOi K15633.
    OMAi IENYMQE.
    OrthoDBi EOG6HJ22X.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00186 .
    BioCyci SSAP342451:GKFA-1976-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1450.10. 1 hit.
    3.40.720.10. 2 hits.
    HAMAPi MF_01038. GpmI.
    InterProi IPR017849. Alkaline_Pase-like_a/b/a.
    IPR017850. Alkaline_phosphatase_core.
    IPR011258. BPG-indep_PGM_N.
    IPR006124. Metalloenzyme.
    IPR005995. Pgm_bpd_ind.
    [Graphical view ]
    Pfami PF06415. iPGM_N. 1 hit.
    PF01676. Metalloenzyme. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001492. IPGAM. 1 hit.
    SUPFAMi SSF53649. SSF53649. 2 hits.
    SSF64158. SSF64158. 1 hit.
    TIGRFAMsi TIGR01307. pgm_bpd_ind. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
      Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
      Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15305 / DSM 20229.

    Entry informationi

    Entry nameiGPMI_STAS1
    AccessioniPrimary (citable) accession number: Q49W02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3