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Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

gpmI

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi12 – 121Manganese 2UniRule annotation
Active sitei62 – 621Phosphoserine intermediateUniRule annotation
Metal bindingi62 – 621Manganese 2UniRule annotation
Metal bindingi397 – 3971Manganese 1UniRule annotation
Metal bindingi401 – 4011Manganese 1UniRule annotation
Metal bindingi438 – 4381Manganese 2UniRule annotation
Metal bindingi439 – 4391Manganese 2UniRule annotation
Metal bindingi456 – 4561Manganese 1UniRule annotation

GO - Molecular functioni

  1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glucose catabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSSAP342451:GKFA-1976-MONOMER.
UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.12UniRule annotation)
Short name:
BPG-independent PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
iPGMUniRule annotation
Gene namesi
Name:gpmIUniRule annotation
Ordered Locus Names:SSP1913
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000006371 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5055052,3-bisphosphoglycerate-independent phosphoglycerate mutasePRO_0000212216Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi342451.SSP1913.

Structurei

3D structure databases

ProteinModelPortaliQ49W02.
SMRiQ49W02. Positions 2-503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BPG-independent phosphoglycerate mutase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0696.
HOGENOMiHOG000223664.
KOiK15633.
OMAiDEFIMPA.
OrthoDBiEOG6HJ22X.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.

Sequencei

Sequence statusi: Complete.

Q49W02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKQPTALII LDGFANRESE HGNAVKLANK PNFDRYYSKY PTTQIEASGL
60 70 80 90 100
DVGLPEGQMG NSEVGHMNIG AGRVVYQSLT RINKSIEDGD FFENDVLNNA
110 120 130 140 150
INHVKKNDSV LHVFGLLSDG GVHSHYKHLF ALLDLAKKQG LEKVYVHAFL
160 170 180 190 200
DGRDVDQKSA LKYIEETEAK FKELGIGQFA SVSGRYYAMD RDKRWDREEK
210 220 230 240 250
AYNAIRNFGG TTFESAKAGV EANYDKDLTD EFVEPFIVQD QNEGVNDGDA
260 270 280 290 300
VIFYNFRPDR AGQLSEIFTD KAFEGFKVEQ INDLFYATFT KYNDNVNAEI
310 320 330 340 350
VFEKVDLTNT IGEVAQDNGL KQLRIAETEK FPHVTYFMSG GRNEEFEGER
360 370 380 390 400
RRLIDSPKVA TYDLKPEMSA YEVKDALIEE LNKGDLDLIL LNFANPDMVG
410 420 430 440 450
HSGMLEPTIK AIEAVDECLG EVVDKITEMG GHAIITADHG NSDMVLTDDD
460 470 480 490 500
QPMTTHTTNP VPVIVTKDGV TLRETGRLGD LAPTLLDLLN VDQPEDMTGE

SLINH
Length:505
Mass (Da):56,343
Last modified:September 13, 2005 - v1
Checksum:i11E64347EBC3B1AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA. Translation: BAE19058.1.
RefSeqiYP_302003.1. NC_007350.1.

Genome annotation databases

EnsemblBacteriaiBAE19058; BAE19058; SSP1913.
KEGGissp:SSP1913.
PATRICi19625407. VBIStaSap90642_1907.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA. Translation: BAE19058.1.
RefSeqiYP_302003.1. NC_007350.1.

3D structure databases

ProteinModelPortaliQ49W02.
SMRiQ49W02. Positions 2-503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi342451.SSP1913.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE19058; BAE19058; SSP1913.
KEGGissp:SSP1913.
PATRICi19625407. VBIStaSap90642_1907.

Phylogenomic databases

eggNOGiCOG0696.
HOGENOMiHOG000223664.
KOiK15633.
OMAiDEFIMPA.
OrthoDBiEOG6HJ22X.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.
BioCyciSSAP342451:GKFA-1976-MONOMER.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
    Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
    Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15305 / DSM 20229.

Entry informationi

Entry nameiGPMI_STAS1
AccessioniPrimary (citable) accession number: Q49W02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: September 13, 2005
Last modified: April 1, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.