ID   GTAB2_STAS1             Reviewed;         289 AA.
AC   Q49VP4;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   27-MAR-2024, entry version 100.
DE   RecName: Full=UTP--glucose-1-phosphate uridylyltransferase 2;
DE            EC=2.7.7.9;
DE   AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase 2;
DE   AltName: Full=UDP-glucose pyrophosphorylase 2;
DE            Short=UDPGP 2;
DE   AltName: Full=Uridine diphosphoglucose pyrophosphorylase 2;
GN   Name=gtaB2; OrderedLocusNames=SSP2021;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS   20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC   Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA   Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- FUNCTION: Catalyzes the formation of UDP-glucose from glucose-1-
CC       phosphate and UTP. This is an intermediate step in the biosynthesis of
CC       diglucosyl-diacylglycerol (Glc2-DAG), i.e. a glycolipid found in the
CC       membrane, which is also used as a membrane anchor for lipoteichoic acid
CC       (LTA) (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC         alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC         ChEBI:CHEBI:58885; EC=2.7.7.9;
CC   -!- PATHWAY: Glycolipid metabolism; diglucosyl-diacylglycerol biosynthesis.
CC   -!- SIMILARITY: Belongs to the UDPGP type 2 family. {ECO:0000305}.
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DR   EMBL; AP008934; BAE19166.1; -; Genomic_DNA.
DR   RefSeq; WP_011303674.1; NZ_MTGA01000039.1.
DR   AlphaFoldDB; Q49VP4; -.
DR   SMR; Q49VP4; -.
DR   GeneID; 66868180; -.
DR   KEGG; ssp:SSP2021; -.
DR   eggNOG; COG1210; Bacteria.
DR   HOGENOM; CLU_029499_1_2_9; -.
DR   OrthoDB; 9803871at2; -.
DR   UniPathway; UPA00894; -.
DR   Proteomes; UP000006371; Chromosome.
DR   GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR   CDD; cd02541; UGPase_prokaryotic; 1.
DR   InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   NCBIfam; TIGR01099; galU; 1.
DR   PANTHER; PTHR43197; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR   PANTHER; PTHR43197:SF1; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Nucleotidyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..289
FT                   /note="UTP--glucose-1-phosphate uridylyltransferase 2"
FT                   /id="PRO_0000308314"
SQ   SEQUENCE   289 AA;  32658 MW;  D8140ABBCCAEB036 CRC64;
     MRKIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEAARAGI EDIIIVTGKH
     KRAIEDHFDN QKELEMILQE KGKTDLLEKV KYSTELANIF YVRQKEQKGL GHAIYSARQF
     IGDEPFAVLL GDDIVESDNP AIKQLIEAYE ETGKSVIGVQ EVDEAQTHRY GIIDPLQKFG
     RKYEVNEFVE KPKQGTAPSN LAIMGRYVLT PDIFDYLATQ GEGAGGEIQL TDAIERLNRA
     DQVYAYDFEG DRYDVGEKLG FVKTTIEYAL KDESMHDELV EFIKKLKLN
//