Reviewed, UniProtKB/Swiss-Prot Q49VP4 (GTAB2_STAS1)

Names and origin

Protein names

Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase 2
    EC=2.7.7.9
Alternative name(s):
    UDP-glucose pyrophosphorylase 2
      Short name=UDPGP 2
    Alpha-D-glucosyl-1-phosphate uridylyltransferase 2
    Uridine diphosphoglucose pyrophosphorylase 2

Gene names

Name:	gtaB2
Ordered Locus Names:	SSP2021

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the formation of UDP-glucose from glucose-1-phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. a glycolipid found in the membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) By similarity.
Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Pathway	Glycolipid metabolism; diglucosyl-diacylglycerol biosynthesis.
Sequence similarities	Belongs to the UDPGP type 2 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	UDP-glucose metabolic process Inferred from electronic annotation. Source: InterPro biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	UTP--glucose-1-phosphate uridylyltransferase 2		PRO_0000308314

Sequences

	Sequence		Length	Mass (Da)
	Q49VP4-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: D8140ABBCCAEB036	FASTA	289	32,658
	10 20 30 40 50 60 MRKIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEAARAGI EDIIIVTGKH 70 80 90 100 110 120 KRAIEDHFDN QKELEMILQE KGKTDLLEKV KYSTELANIF YVRQKEQKGL GHAIYSARQF 130 140 150 160 170 180 IGDEPFAVLL GDDIVESDNP AIKQLIEAYE ETGKSVIGVQ EVDEAQTHRY GIIDPLQKFG 190 200 210 220 230 240 RKYEVNEFVE KPKQGTAPSN LAIMGRYVLT PDIFDYLATQ GEGAGGEIQL TDAIERLNRA 250 260 270 280 DQVYAYDFEG DRYDVGEKLG FVKTTIEYAL KDESMHDELV EFIKKLKLN

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008934 Genomic DNA. Translation: BAE19166.1.
RefSeq	YP_302111.1.
3D structure databases
HSSP	HSSP built from PDB template 1IIN based on UniProtKB P26393.
SMR	Q49VP4. Positions 2-285.
ModBase	Search...
Protein-protein interaction databases
STRING	Q49VP4.
Genome annotation databases
GeneID	3616735.
GenomeReviews	Gene locus SSP2021 in contig AP008934_GR.
KEGG	ssp:SSP2021.
NMPDR	fig|342451.4.peg.2174.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1210.
HOGENOM	HBG688195.
OMA	SIVGVET.
PhylomeDB	Q49VP4.
Enzyme and pathway databases
BioCyc	SSAP342451:SSP2021-MONOMER.
Family and domain databases
InterPro	IPR005771. GalU_uridylyltTrfase_bac/arc. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01099. galU. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GTAB2_STAS1

Accession

Primary (citable) accession number: Q49VP4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	September 13, 2005
Last modified:	February 9, 2010
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)