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Q49VP4 (GTAB2_STAS1) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UTP--glucose-1-phosphate uridylyltransferase 2

EC=2.7.7.9
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase 2
UDP-glucose pyrophosphorylase 2
Short name=UDPGP 2
Uridine diphosphoglucose pyrophosphorylase 2
Gene names
Name:gtaB2
Ordered Locus Names:SSP2021
OrganismStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]
Taxonomic identifier342451 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of UDP-glucose from glucose-1-phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. a glycolipid found in the membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) By similarity.

Catalytic activity

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathway

Glycolipid metabolism; diglucosyl-diacylglycerol biosynthesis.

Sequence similarities

Belongs to the UDPGP type 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289UTP--glucose-1-phosphate uridylyltransferase 2
PRO_0000308314

Sequences

Sequence LengthMass (Da)Tools
Q49VP4 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: D8140ABBCCAEB036

FASTA28932,658
        10         20         30         40         50         60 
MRKIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEAARAGI EDIIIVTGKH 

        70         80         90        100        110        120 
KRAIEDHFDN QKELEMILQE KGKTDLLEKV KYSTELANIF YVRQKEQKGL GHAIYSARQF 

       130        140        150        160        170        180 
IGDEPFAVLL GDDIVESDNP AIKQLIEAYE ETGKSVIGVQ EVDEAQTHRY GIIDPLQKFG 

       190        200        210        220        230        240 
RKYEVNEFVE KPKQGTAPSN LAIMGRYVLT PDIFDYLATQ GEGAGGEIQL TDAIERLNRA 

       250        260        270        280 
DQVYAYDFEG DRYDVGEKLG FVKTTIEYAL KDESMHDELV EFIKKLKLN 

« Hide

References

[1]"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15305 / DSM 20229.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008934 Genomic DNA. Translation: BAE19166.1.
RefSeqYP_302111.1. NC_007350.1.

3D structure databases

ProteinModelPortalQ49VP4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING342451.SSP2021.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE19166; BAE19166; SSP2021.
GeneID3616735.
KEGGssp:SSP2021.
PATRIC19625623. VBIStaSap90642_2014.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1210.
HOGENOMHOG000283477.
KOK00963.
OMAKLIDECS.
OrthoDBEOG6Z9B3V.

Enzyme and pathway databases

BioCycSSAP342451:GKFA-2085-MONOMER.
UniPathwayUPA00894.

Family and domain databases

Gene3D3.90.550.10. 1 hit.
InterProIPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMSSF53448. SSF53448. 1 hit.
TIGRFAMsTIGR01099. galU. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGTAB2_STAS1
AccessionPrimary (citable) accession number: Q49VP4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: September 13, 2005
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways