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Q49VN8

- MDH_STAS1

UniProt

Q49VN8 - MDH_STAS1

Protein

Malate dehydrogenase

Gene

mdh

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341NADUniRule annotation
    Binding sitei85 – 851SubstrateUniRule annotation
    Binding sitei91 – 911SubstrateUniRule annotation
    Binding sitei98 – 981NADUniRule annotation
    Binding sitei123 – 1231SubstrateUniRule annotation
    Binding sitei154 – 1541SubstrateUniRule annotation
    Active sitei178 – 1781Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156NADUniRule annotation
    Nucleotide bindingi121 – 1233NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciSSAP342451:GKFA-2091-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:SSP2027
    OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
    Taxonomic identifieri342451 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000006371: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Malate dehydrogenasePRO_0000241968Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi342451.SSP2027.

    Structurei

    3D structure databases

    ProteinModelPortaliQ49VN8.
    SMRiQ49VN8. Positions 5-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiFVINVAN.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q49VN8-1 [UniParc]FASTAAdd to Basket

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    MTKKKISIIG AGNTGATLAF IVAQHELADV VLIDRPDNEG QVKGKALDIF    50
    ESSPVYGFDA KVTGSVNYAD TADSDIVVIT AGSPRKPGMS RDDLVQINEK 100
    VMFDVTKEIV KYSPDCKIIV LTNPVDAMTY SVLKASGFPK ERVIGQSGVL 150
    DTARYQSFIA EALNVSIKDI RGLVLGGHGD TMVPLVNSTN VNGVPLHQLL 200
    NQTQIEQIVE RTRKGGAEIV ALLGNGSAYY APASAVFEMI EAILKDQHRL 250
    LPSIALLEGE YGFSDICLGV PTVLSEKGIE NIVELALSDN EQAQLRISAD 300
    SVEEVKQALK NQ 312
    Length:312
    Mass (Da):33,541
    Last modified:September 13, 2005 - v1
    Checksum:i7C014156766B7C32
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008934 Genomic DNA. Translation: BAE19172.1.
    RefSeqiYP_302117.1. NC_007350.1.

    Genome annotation databases

    EnsemblBacteriaiBAE19172; BAE19172; SSP2027.
    GeneIDi3615591.
    KEGGissp:SSP2027.
    PATRICi19625635. VBIStaSap90642_2020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008934 Genomic DNA. Translation: BAE19172.1 .
    RefSeqi YP_302117.1. NC_007350.1.

    3D structure databases

    ProteinModelPortali Q49VN8.
    SMRi Q49VN8. Positions 5-305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 342451.SSP2027.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE19172 ; BAE19172 ; SSP2027 .
    GeneIDi 3615591.
    KEGGi ssp:SSP2027.
    PATRICi 19625635. VBIStaSap90642_2020.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi FVINVAN.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci SSAP342451:GKFA-2091-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
      Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
      Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15305 / DSM 20229.

    Entry informationi

    Entry nameiMDH_STAS1
    AccessioniPrimary (citable) accession number: Q49VN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3