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Protein

Malate dehydrogenase

Gene

mdh

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADUniRule annotation1
Binding sitei85SubstrateUniRule annotation1
Binding sitei91SubstrateUniRule annotation1
Binding sitei98NADUniRule annotation1
Binding sitei123SubstrateUniRule annotation1
Binding sitei154SubstrateUniRule annotation1
Active sitei178Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADUniRule annotation6
Nucleotide bindingi121 – 123NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:SSP2027
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000006371 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002419681 – 312Malate dehydrogenaseAdd BLAST312

Interactioni

Protein-protein interaction databases

STRINGi342451.SSP2027.

Structurei

3D structure databases

ProteinModelPortaliQ49VN8.
SMRiQ49VN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213794.
KOiK00024.
OMAiRQPGQTR.
OrthoDBiPOG091H02N6.

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
PANTHERiPTHR11540:SF31. PTHR11540:SF31. 1 hit.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q49VN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKKKISIIG AGNTGATLAF IVAQHELADV VLIDRPDNEG QVKGKALDIF
60 70 80 90 100
ESSPVYGFDA KVTGSVNYAD TADSDIVVIT AGSPRKPGMS RDDLVQINEK
110 120 130 140 150
VMFDVTKEIV KYSPDCKIIV LTNPVDAMTY SVLKASGFPK ERVIGQSGVL
160 170 180 190 200
DTARYQSFIA EALNVSIKDI RGLVLGGHGD TMVPLVNSTN VNGVPLHQLL
210 220 230 240 250
NQTQIEQIVE RTRKGGAEIV ALLGNGSAYY APASAVFEMI EAILKDQHRL
260 270 280 290 300
LPSIALLEGE YGFSDICLGV PTVLSEKGIE NIVELALSDN EQAQLRISAD
310
SVEEVKQALK NQ
Length:312
Mass (Da):33,541
Last modified:September 13, 2005 - v1
Checksum:i7C014156766B7C32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA. Translation: BAE19172.1.
RefSeqiWP_002483968.1. NZ_MTGA01000039.1.

Genome annotation databases

EnsemblBacteriaiBAE19172; BAE19172; SSP2027.
GeneIDi3615591.
KEGGissp:SSP2027.

Similar proteinsi

Entry informationi

Entry nameiMDH_STAS1
AccessioniPrimary (citable) accession number: Q49VN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: September 13, 2005
Last modified: August 30, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families