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Q49VN0

- UPPP_STAS1

UniProt

Q49VN0 - UPPP_STAS1

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciSSAP342451:GKFA-2099-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:SSP2035
    OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
    Taxonomic identifieri342451 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000006371: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291Undecaprenyl-diphosphatasePRO_0000227641Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi342451.SSP2035.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei48 – 6821HelicalUniRule annotationAdd
    BLAST
    Transmembranei99 – 11921HelicalUniRule annotationAdd
    BLAST
    Transmembranei123 – 14321HelicalUniRule annotationAdd
    BLAST
    Transmembranei159 – 17921HelicalUniRule annotationAdd
    BLAST
    Transmembranei200 – 22021HelicalUniRule annotationAdd
    BLAST
    Transmembranei236 – 25621HelicalUniRule annotationAdd
    BLAST
    Transmembranei269 – 28921HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiWRKISSS.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q49VN0-1 [UniParc]FASTAAdd to Basket

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    MLILELIKGI ILGIVEGLTE FAPVSSTGHM ILVDDMWLKS SEFLGSQSAF    50
    TFKIVIQLGS VFAGAWVFRE RYFEMLHIGK YRHEPIDGIG QKPKRLNLLH 100
    IIVGMIPAGV LGLLFDDVIQ EYLFSVPTVM IGLFIGAIYM IIADIYSKKV 150
    TNPRNVDQIN YFQAFVIGLS QAIAMWPGFS RSGSTISTGV LMKMNHKSAS 200
    DFTFIMAVPV MLAASGLSLV KNMEYIHMSD IGFYVLGFLA AFIVGLIAIK 250
    TFLYLISKIK LIPFAIYRIV LVIIIAILYF GFGIGQGITG E 291
    Length:291
    Mass (Da):32,210
    Last modified:September 13, 2005 - v1
    Checksum:iED759E74E27211AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008934 Genomic DNA. Translation: BAE19180.1.
    RefSeqiYP_302125.1. NC_007350.1.

    Genome annotation databases

    EnsemblBacteriaiBAE19180; BAE19180; SSP2035.
    GeneIDi3615599.
    KEGGissp:SSP2035.
    PATRICi19625651. VBIStaSap90642_2028.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008934 Genomic DNA. Translation: BAE19180.1 .
    RefSeqi YP_302125.1. NC_007350.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 342451.SSP2035.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE19180 ; BAE19180 ; SSP2035 .
    GeneIDi 3615599.
    KEGGi ssp:SSP2035.
    PATRICi 19625651. VBIStaSap90642_2028.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi WRKISSS.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci SSAP342451:GKFA-2099-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
      Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
      Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15305 / DSM 20229.

    Entry informationi

    Entry nameiUPPP_STAS1
    AccessioniPrimary (citable) accession number: Q49VN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3