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Q49VB3 (GCH4_STAS1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:SSP2152
OrganismStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]
Taxonomic identifier342451 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000289526

Sites

Site1761May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q49VB3 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 0AF31917ACC05B06

FASTA29233,579
        10         20         30         40         50         60 
MTEFDLSTRE GRWKHFGSVD PIEGTKPTIK EEMKDLQSTH KNFLFEIEEV GIKNLVYPVL 

        70         80         90        100        110        120 
VDRFQTAGNF SFSTSLNLDE KGINMSRILE SVEKHYHNGI ELDFDALYQL LRSLQERMNQ 

       130        140        150        160        170        180 
NAAGLDVSAK WFFDRFSPIT QIKAVGHADV TYGLAIDKQN VTRKEITIEA AVTTLCPCSK 

       190        200        210        220        230        240 
EISEYSAHNQ RGIVTVKAYI NKDIELIDNY KDVILDAMEA NASSILYPIL KRPDEKSVTE 

       250        260        270        280        290 
RAYENPRFVE DLIRLIAADL VDFDWLDGFD IECRNEESIH QHDAFAKLKY RK 

« Hide

References

[1]"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15305 / DSM 20229.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008934 Genomic DNA. Translation: BAE19297.1.
RefSeqYP_302242.1. NC_007350.1.

3D structure databases

ProteinModelPortalQ49VB3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING342451.SSP2152.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE19297; BAE19297; SSP2152.
GeneID3616398.
KEGGssp:SSP2152.
PATRIC19625881. VBIStaSap90642_2143.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280679.
KOK09007.
OMAAKWFFDR.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

BioCycSSAP342451:GKFA-2216-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00294. TIGR00294. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCH4_STAS1
AccessionPrimary (citable) accession number: Q49VB3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways