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Q49VB3

- GCH4_STAS1

UniProt

Q49VB3 - GCH4_STAS1

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, SSP2152
Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei176 – 1761May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSSAP342451:GKFA-2216-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:SSP2152
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000006371: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292GTP cyclohydrolase FolE2UniRule annotation
PRO_0000289526Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi342451.SSP2152.

Structurei

3D structure databases

ProteinModelPortaliQ49VB3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiAKWFFDR.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

Q49VB3-1 [UniParc]FASTAAdd to Basket

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MTEFDLSTRE GRWKHFGSVD PIEGTKPTIK EEMKDLQSTH KNFLFEIEEV    50
GIKNLVYPVL VDRFQTAGNF SFSTSLNLDE KGINMSRILE SVEKHYHNGI 100
ELDFDALYQL LRSLQERMNQ NAAGLDVSAK WFFDRFSPIT QIKAVGHADV 150
TYGLAIDKQN VTRKEITIEA AVTTLCPCSK EISEYSAHNQ RGIVTVKAYI 200
NKDIELIDNY KDVILDAMEA NASSILYPIL KRPDEKSVTE RAYENPRFVE 250
DLIRLIAADL VDFDWLDGFD IECRNEESIH QHDAFAKLKY RK 292
Length:292
Mass (Da):33,579
Last modified:September 13, 2005 - v1
Checksum:i0AF31917ACC05B06
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE19297.1.
RefSeqiWP_002484093.1. NC_007350.1.
YP_302242.1. NC_007350.1.

Genome annotation databases

EnsemblBacteriaiBAE19297; BAE19297; SSP2152.
GeneIDi3616398.
KEGGissp:SSP2152.
PATRICi19625881. VBIStaSap90642_2143.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE19297.1 .
RefSeqi WP_002484093.1. NC_007350.1.
YP_302242.1. NC_007350.1.

3D structure databases

ProteinModelPortali Q49VB3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 342451.SSP2152.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE19297 ; BAE19297 ; SSP2152 .
GeneIDi 3616398.
KEGGi ssp:SSP2152.
PATRICi 19625881. VBIStaSap90642_2143.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi AKWFFDR.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci SSAP342451:GKFA-2216-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
    Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
    Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15305 / DSM 20229.

Entry informationi

Entry nameiGCH4_STAS1
AccessioniPrimary (citable) accession number: Q49VB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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