Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q49UX4

- SLE1_STAS1

UniProt

Q49UX4 - SLE1_STAS1

Protein

N-acetylmuramoyl-L-alanine amidase sle1

Gene

sle1

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Peptidoglycan hydrolase involved in the splitting of the septum during cell division.By similarity

    Catalytic activityi

    Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

    GO - Molecular functioni

    1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. barrier septum assembly Source: UniProtKB-KW
    2. cytolysis Source: UniProtKB-KW
    3. defense response to bacterium Source: UniProtKB-KW
    4. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Hydrolase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell wall biogenesis/degradation, Septation, Virulence

    Enzyme and pathway databases

    BioCyciSSAP342451:GKFA-2375-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetylmuramoyl-L-alanine amidase sle1 (EC:3.5.1.28)
    Gene namesi
    Name:sle1
    Synonyms:aaa
    Ordered Locus Names:SSP2291
    OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
    Taxonomic identifieri342451 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000006371: Chromosome

    Subcellular locationi

    Secreted By similarity. Cell surface By similarity

    GO - Cellular componenti

    1. cell surface Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 327302N-acetylmuramoyl-L-alanine amidase sle1PRO_0000231630Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi342451.SSP2291.

    Structurei

    3D structure databases

    ProteinModelPortaliQ49UX4.
    SMRiQ49UX4. Positions 214-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati29 – 7143LysM 1Add
    BLAST
    Repeati88 – 13043LysM 2Add
    BLAST
    Repeati152 – 19443LysM 3Add
    BLAST
    Domaini203 – 327125Peptidase C51PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 LysM repeats.Curated
    Contains 1 peptidase C51 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG3942.
    HOGENOMiHOG000279823.
    OMAiEMNYSAS.
    OrthoDBiEOG6GTZPF.

    Family and domain databases

    Gene3Di3.10.350.10. 3 hits.
    InterProiIPR007921. CHAP_dom.
    IPR018392. LysM_dom.
    [Graphical view]
    PfamiPF05257. CHAP. 1 hit.
    PF01476. LysM. 3 hits.
    [Graphical view]
    SMARTiSM00257. LysM. 3 hits.
    [Graphical view]
    SUPFAMiSSF54106. SSF54106. 3 hits.
    PROSITEiPS50911. CHAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q49UX4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKKIIATVI GTSALAAVTW TNADAATTYK VKSGDSLWSI ANKYNMSVAK    50
    LKSLNNLTSN VIFPNQSLKV SGSTSSSTSS NTSTGSTYTV KSGDTLSGIA 100
    AKYGTTYQKI MSLNGLSNFN IYPGQKLKVS GAASSSSSNT SGNTSSGSTT 150
    TYTVKSGDSL SAIAAKYGTT YQKIMSLNGL TNFNIYPGQK LKVSGKASTG 200
    GSGSSSTGSA GYKTPVFNHS NLYDWGQCTW HVFNKRAQIG KGISTYWWNA 250
    NNWDTAAAAD GYTIDRKATV GSILQSDMGY YGHVAFVESV NANGSITISE 300
    MNYSASPGIV TYRTIPASQV SSYVYIH 327
    Length:327
    Mass (Da):34,491
    Last modified:September 13, 2005 - v1
    Checksum:i32B7759C57878F5A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008934 Genomic DNA. Translation: BAE19436.1.
    RefSeqiWP_011303892.1. NC_007350.1.
    YP_302381.1. NC_007350.1.

    Genome annotation databases

    EnsemblBacteriaiBAE19436; BAE19436; SSP2291.
    GeneIDi3615679.
    KEGGissp:SSP2291.
    PATRICi19626199. VBIStaSap90642_2282.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008934 Genomic DNA. Translation: BAE19436.1 .
    RefSeqi WP_011303892.1. NC_007350.1.
    YP_302381.1. NC_007350.1.

    3D structure databases

    ProteinModelPortali Q49UX4.
    SMRi Q49UX4. Positions 214-327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 342451.SSP2291.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE19436 ; BAE19436 ; SSP2291 .
    GeneIDi 3615679.
    KEGGi ssp:SSP2291.
    PATRICi 19626199. VBIStaSap90642_2282.

    Phylogenomic databases

    eggNOGi COG3942.
    HOGENOMi HOG000279823.
    OMAi EMNYSAS.
    OrthoDBi EOG6GTZPF.

    Enzyme and pathway databases

    BioCyci SSAP342451:GKFA-2375-MONOMER.

    Family and domain databases

    Gene3Di 3.10.350.10. 3 hits.
    InterProi IPR007921. CHAP_dom.
    IPR018392. LysM_dom.
    [Graphical view ]
    Pfami PF05257. CHAP. 1 hit.
    PF01476. LysM. 3 hits.
    [Graphical view ]
    SMARTi SM00257. LysM. 3 hits.
    [Graphical view ]
    SUPFAMi SSF54106. SSF54106. 3 hits.
    PROSITEi PS50911. CHAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
      Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
      Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15305 / DSM 20229.

    Entry informationi

    Entry nameiSLE1_STAS1
    AccessioniPrimary (citable) accession number: Q49UX4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3