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Protein

N-acetylmuramoyl-L-alanine amidase sle1

Gene

sle1

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Peptidoglycan hydrolase involved in the splitting of the septum during cell division.By similarity

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell wall biogenesis/degradation, Septation, Virulence

Enzyme and pathway databases

BioCyciSSAP342451:GKFA-2375-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase sle1 (EC:3.5.1.28)
Gene namesi
Name:sle1
Synonyms:aaa
Ordered Locus Names:SSP2291
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000006371 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 327302N-acetylmuramoyl-L-alanine amidase sle1PRO_0000231630Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi342451.SSP2291.

Structurei

3D structure databases

ProteinModelPortaliQ49UX4.
SMRiQ49UX4. Positions 214-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati29 – 7143LysM 1Add
BLAST
Repeati88 – 13043LysM 2Add
BLAST
Repeati152 – 19443LysM 3Add
BLAST
Domaini203 – 327125Peptidase C51PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 LysM repeats.Curated
Contains 1 peptidase C51 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG3942.
HOGENOMiHOG000279823.
OMAiTTYQHIM.
OrthoDBiEOG6GTZPF.

Family and domain databases

Gene3Di3.10.350.10. 3 hits.
InterProiIPR007921. CHAP_dom.
IPR018392. LysM_dom.
[Graphical view]
PfamiPF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view]
SMARTiSM00257. LysM. 3 hits.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 3 hits.
PROSITEiPS50911. CHAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q49UX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKKIIATVI GTSALAAVTW TNADAATTYK VKSGDSLWSI ANKYNMSVAK
60 70 80 90 100
LKSLNNLTSN VIFPNQSLKV SGSTSSSTSS NTSTGSTYTV KSGDTLSGIA
110 120 130 140 150
AKYGTTYQKI MSLNGLSNFN IYPGQKLKVS GAASSSSSNT SGNTSSGSTT
160 170 180 190 200
TYTVKSGDSL SAIAAKYGTT YQKIMSLNGL TNFNIYPGQK LKVSGKASTG
210 220 230 240 250
GSGSSSTGSA GYKTPVFNHS NLYDWGQCTW HVFNKRAQIG KGISTYWWNA
260 270 280 290 300
NNWDTAAAAD GYTIDRKATV GSILQSDMGY YGHVAFVESV NANGSITISE
310 320
MNYSASPGIV TYRTIPASQV SSYVYIH
Length:327
Mass (Da):34,491
Last modified:September 13, 2005 - v1
Checksum:i32B7759C57878F5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA. Translation: BAE19436.1.
RefSeqiWP_011303892.1. NC_007350.1.

Genome annotation databases

EnsemblBacteriaiBAE19436; BAE19436; SSP2291.
GeneIDi23779430.
KEGGissp:SSP2291.
PATRICi19626199. VBIStaSap90642_2282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA. Translation: BAE19436.1.
RefSeqiWP_011303892.1. NC_007350.1.

3D structure databases

ProteinModelPortaliQ49UX4.
SMRiQ49UX4. Positions 214-327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi342451.SSP2291.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE19436; BAE19436; SSP2291.
GeneIDi23779430.
KEGGissp:SSP2291.
PATRICi19626199. VBIStaSap90642_2282.

Phylogenomic databases

eggNOGiCOG3942.
HOGENOMiHOG000279823.
OMAiTTYQHIM.
OrthoDBiEOG6GTZPF.

Enzyme and pathway databases

BioCyciSSAP342451:GKFA-2375-MONOMER.

Family and domain databases

Gene3Di3.10.350.10. 3 hits.
InterProiIPR007921. CHAP_dom.
IPR018392. LysM_dom.
[Graphical view]
PfamiPF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view]
SMARTiSM00257. LysM. 3 hits.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 3 hits.
PROSITEiPS50911. CHAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
    Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
    Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15305 / DSM 20229.

Entry informationi

Entry nameiSLE1_STAS1
AccessioniPrimary (citable) accession number: Q49UX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: September 13, 2005
Last modified: July 22, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.