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Protein

N-acetylmuramoyl-L-alanine amidase sle1

Gene

sle1

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Peptidoglycan hydrolase involved in the splitting of the septum during cell division.By similarity

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Hydrolase
Biological processCell cycle, Cell division, Cell wall biogenesis/degradation, Septation, Virulence

Protein family/group databases

CAZyiCBM50. Carbohydrate-Binding Module Family 50.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase sle1 (EC:3.5.1.28)
Gene namesi
Name:sle1
Synonyms:aaa
Ordered Locus Names:SSP2291
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000006371 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000023163026 – 327N-acetylmuramoyl-L-alanine amidase sle1Add BLAST302

Interactioni

Protein-protein interaction databases

STRINGi342451.SSP2291.

Structurei

3D structure databases

ProteinModelPortaliQ49UX4.
SMRiQ49UX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 70LysM 1PROSITE-ProRule annotationAdd BLAST44
Domaini86 – 129LysM 2PROSITE-ProRule annotationAdd BLAST44
Domaini150 – 193LysM 3PROSITE-ProRule annotationAdd BLAST44
Domaini203 – 327Peptidase C51PROSITE-ProRule annotationAdd BLAST125

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG41068JE. Bacteria.
COG1388. LUCA.
COG3942. LUCA.
HOGENOMiHOG000279823.
OMAiNTPVFNH.
OrthoDBiPOG090Q042B.

Family and domain databases

CDDicd00118. LysM. 3 hits.
Gene3Di3.10.350.10. 3 hits.
InterProiView protein in InterPro
IPR007921. CHAP_dom.
IPR018392. LysM_dom.
PfamiView protein in Pfam
PF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
SMARTiView protein in SMART
SM00257. LysM. 3 hits.
SUPFAMiSSF54106. SSF54106. 3 hits.
PROSITEiView protein in PROSITE
PS50911. CHAP. 1 hit.
PS51782. LYSM. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q49UX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKKIIATVI GTSALAAVTW TNADAATTYK VKSGDSLWSI ANKYNMSVAK
60 70 80 90 100
LKSLNNLTSN VIFPNQSLKV SGSTSSSTSS NTSTGSTYTV KSGDTLSGIA
110 120 130 140 150
AKYGTTYQKI MSLNGLSNFN IYPGQKLKVS GAASSSSSNT SGNTSSGSTT
160 170 180 190 200
TYTVKSGDSL SAIAAKYGTT YQKIMSLNGL TNFNIYPGQK LKVSGKASTG
210 220 230 240 250
GSGSSSTGSA GYKTPVFNHS NLYDWGQCTW HVFNKRAQIG KGISTYWWNA
260 270 280 290 300
NNWDTAAAAD GYTIDRKATV GSILQSDMGY YGHVAFVESV NANGSITISE
310 320
MNYSASPGIV TYRTIPASQV SSYVYIH
Length:327
Mass (Da):34,491
Last modified:September 13, 2005 - v1
Checksum:i32B7759C57878F5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA. Translation: BAE19436.1.
RefSeqiWP_011303892.1. NC_007350.1.

Genome annotation databases

EnsemblBacteriaiBAE19436; BAE19436; SSP2291.
GeneIDi3615679.
KEGGissp:SSP2291.
PATRICi19626199. VBIStaSap90642_2282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA. Translation: BAE19436.1.
RefSeqiWP_011303892.1. NC_007350.1.

3D structure databases

ProteinModelPortaliQ49UX4.
SMRiQ49UX4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi342451.SSP2291.

Protein family/group databases

CAZyiCBM50. Carbohydrate-Binding Module Family 50.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE19436; BAE19436; SSP2291.
GeneIDi3615679.
KEGGissp:SSP2291.
PATRICi19626199. VBIStaSap90642_2282.

Phylogenomic databases

eggNOGiENOG41068JE. Bacteria.
COG1388. LUCA.
COG3942. LUCA.
HOGENOMiHOG000279823.
OMAiNTPVFNH.
OrthoDBiPOG090Q042B.

Family and domain databases

CDDicd00118. LysM. 3 hits.
Gene3Di3.10.350.10. 3 hits.
InterProiView protein in InterPro
IPR007921. CHAP_dom.
IPR018392. LysM_dom.
PfamiView protein in Pfam
PF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
SMARTiView protein in SMART
SM00257. LysM. 3 hits.
SUPFAMiSSF54106. SSF54106. 3 hits.
PROSITEiView protein in PROSITE
PS50911. CHAP. 1 hit.
PS51782. LYSM. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiSLE1_STAS1
AccessioniPrimary (citable) accession number: Q49UX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: September 13, 2005
Last modified: February 15, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.