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Q49UX4

- SLE1_STAS1

UniProt

Q49UX4 - SLE1_STAS1

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Protein

N-acetylmuramoyl-L-alanine amidase sle1

Gene
sle1, aaa, SSP2291
Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Peptidoglycan hydrolase involved in the splitting of the septum during cell division By similarity.

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

GO - Biological processi

  1. barrier septum assembly Source: UniProtKB-KW
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell wall biogenesis/degradation, Septation, Virulence

Enzyme and pathway databases

BioCyciSSAP342451:GKFA-2375-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase sle1 (EC:3.5.1.28)
Gene namesi
Name:sle1
Synonyms:aaa
Ordered Locus Names:SSP2291
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000006371: Chromosome

Subcellular locationi

Secreted By similarity. Cell surface By similarity

GO - Cellular componenti

  1. cell surface Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 327302N-acetylmuramoyl-L-alanine amidase sle1PRO_0000231630Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi342451.SSP2291.

Structurei

3D structure databases

ProteinModelPortaliQ49UX4.
SMRiQ49UX4. Positions 214-327.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati29 – 7143LysM 1Add
BLAST
Repeati88 – 13043LysM 2Add
BLAST
Repeati152 – 19443LysM 3Add
BLAST
Domaini203 – 327125Peptidase C51Add
BLAST

Sequence similaritiesi

Contains 3 LysM repeats.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG3942.
HOGENOMiHOG000279823.
OMAiEMNYSAS.
OrthoDBiEOG6GTZPF.

Family and domain databases

Gene3Di3.10.350.10. 3 hits.
InterProiIPR007921. CHAP_dom.
IPR018392. LysM_dom.
[Graphical view]
PfamiPF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view]
SMARTiSM00257. LysM. 3 hits.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 3 hits.
PROSITEiPS50911. CHAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q49UX4-1 [UniParc]FASTAAdd to Basket

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MRKKIIATVI GTSALAAVTW TNADAATTYK VKSGDSLWSI ANKYNMSVAK    50
LKSLNNLTSN VIFPNQSLKV SGSTSSSTSS NTSTGSTYTV KSGDTLSGIA 100
AKYGTTYQKI MSLNGLSNFN IYPGQKLKVS GAASSSSSNT SGNTSSGSTT 150
TYTVKSGDSL SAIAAKYGTT YQKIMSLNGL TNFNIYPGQK LKVSGKASTG 200
GSGSSSTGSA GYKTPVFNHS NLYDWGQCTW HVFNKRAQIG KGISTYWWNA 250
NNWDTAAAAD GYTIDRKATV GSILQSDMGY YGHVAFVESV NANGSITISE 300
MNYSASPGIV TYRTIPASQV SSYVYIH 327
Length:327
Mass (Da):34,491
Last modified:September 13, 2005 - v1
Checksum:i32B7759C57878F5A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE19436.1.
RefSeqiWP_011303892.1. NC_007350.1.
YP_302381.1. NC_007350.1.

Genome annotation databases

EnsemblBacteriaiBAE19436; BAE19436; SSP2291.
GeneIDi3615679.
KEGGissp:SSP2291.
PATRICi19626199. VBIStaSap90642_2282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE19436.1 .
RefSeqi WP_011303892.1. NC_007350.1.
YP_302381.1. NC_007350.1.

3D structure databases

ProteinModelPortali Q49UX4.
SMRi Q49UX4. Positions 214-327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 342451.SSP2291.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE19436 ; BAE19436 ; SSP2291 .
GeneIDi 3615679.
KEGGi ssp:SSP2291.
PATRICi 19626199. VBIStaSap90642_2282.

Phylogenomic databases

eggNOGi COG3942.
HOGENOMi HOG000279823.
OMAi EMNYSAS.
OrthoDBi EOG6GTZPF.

Enzyme and pathway databases

BioCyci SSAP342451:GKFA-2375-MONOMER.

Family and domain databases

Gene3Di 3.10.350.10. 3 hits.
InterProi IPR007921. CHAP_dom.
IPR018392. LysM_dom.
[Graphical view ]
Pfami PF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view ]
SMARTi SM00257. LysM. 3 hits.
[Graphical view ]
SUPFAMi SSF54106. SSF54106. 3 hits.
PROSITEi PS50911. CHAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
    Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
    Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15305 / DSM 20229.

Entry informationi

Entry nameiSLE1_STAS1
AccessioniPrimary (citable) accession number: Q49UX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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