Reviewed, UniProtKB/Swiss-Prot Q49UM5 (CYSC_STAS1)

Names and origin

Protein names

Recommended name:
    Adenylyl-sulfate kinase
    EC=2.7.1.25
Alternative name(s):
    APS kinase
    Adenosine-5'-phosphosulfate kinase
    ATP adenosine-5'-phosphosulfate 3'-phosphotransferase

Gene names

Name:	cysC
Ordered Locus Names:	SSP2401

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the synthesis of activated sulfate. HAMAP MF_00065
Catalytic activity	ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate. HAMAP MF_00065
Pathway	Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3. HAMAP MF_00065
Sequence similarities	Belongs to the APS kinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	sulfate assimilation Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP adenylylsulfate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 204	204	Adenylyl-sulfate kinase HAMAP MF_00065		PRO_1000009037
Regions
	Nucleotide binding	34 – 41	8	ATP By similarity
Sites
	Active site	108	1	Phosphoserine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q49UM5-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: D51AE4F2DAE29925	FASTA	204	23,196
	10 20 30 40 50 60 MATSNHITWH ESAVTKVERQ QRNQHRSVVI WFTGLSGSGK STISVALEKA LYQQQVHTYR 70 80 90 100 110 120 LDGDNVRHGL NNNLGFSPED RKENIRRIGE VSKLMVDAGL ITITAFISPY QADRDEVRNL 130 140 150 160 170 180 LDDKEFIEIY TSCSIETCES RDPKGLYQKA RNGEIKGFTG INAPYEEPNN PEIIIDTEQD 190 200 SIETAVNQII DYLKVHDYLD VKPV

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP008934 Genomic DNA. Translation: BAE19546.1.
RefSeq	YP_302491.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3617305.
GenomeReviews	Gene locus SSP2401 in contig AP008934_GR.
KEGG	ssp:SSP2401.
NMPDR	fig|342451.4.peg.2401.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q49UM5.
OMA	Q49UM5. IVWHQHS.
Enzyme and pathway databases
BioCyc	SSAP342451:SSP2401-MON.
Family and domain databases
HAMAP	MF_00065. [Tree]
InterPro	IPR002891. APS_kinase_C. [Graphical view]
Pfam	PF01583. APS_kinase. 1 hit. [Graphical view]
ProDom	PD002350. APS_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00455. apsK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CYSC_STAS1

Accession

Primary (citable) accession number: Q49UM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)