Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q49UL7 (CYSH_STAS1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoadenosine phosphosulfate reductase

EC=1.8.4.8
Alternative name(s):
3'-phosphoadenylylsulfate reductase
PAPS reductase, thioredoxin dependent
PAPS sulfotransferase
PAdoPS reductase
Gene names
Name:cysH
Ordered Locus Names:SSP2409
OrganismStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]
Taxonomic identifier342451 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesStaphylococcus

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Reduction of activated sulfate into sulfite. HAMAP MF_00063

Catalytic activity

Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin. HAMAP MF_00063

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3. HAMAP MF_00063

Subcellular location

Cytoplasm By similarity HAMAP MF_00063.

Sequence similarities

Belongs to the PAPS reductase family. CysH subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 242242Phosphoadenosine phosphosulfate reductase HAMAP MF_00063
PRO_0000100648

Sequences

Sequence LengthMass (Da)Tools
Q49UL7 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 9179A05F32ACDAB5

FASTA24227,742
        10         20         30         40         50         60 
MSETKITYDD FNPHAFETLD ITDETKGARE VIRWAYDVYG DSIIYSCSFG AEGMILIDLI 

        70         80         90        100        110        120 
SSVKKDAEIV FLDTNLHFQE TYDLIDRVKA RYPELNIKLK QPSLTLEEQA DQVAPALWKQ 

       130        140        150        160        170        180 
DPNQCCYIRK IKPLEEVLSG ATAWVSGLRR EQSPSRQATN FINKDERFKS VKVCPLIHWT 

       190        200        210        220        230        240 
WDDVWDYIKA HDLHYNELHD FNFPSIGCIP CTEAVSGNGD SRAGRWTNST KTECGLHTTN 


KP 

« Hide

References

[1]"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15305 / DSM 20229.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008934 Genomic DNA. Translation: BAE19554.1.
RefSeqYP_302499.1. NC_007350.1.

3D structure databases

ProteinModelPortalQ49UL7.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ49UL7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000048051; EBSTAP00000046420; EBSTAG00000048048.
GeneID3617313.
GenomeReviewsGene locus SSP2409 in contig AP008934_GR.
KEGGssp:SSP2409.
NMPDRfig|342451.4.peg.2409.
PATRIC19626421. VBIStaSap90642_2394.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0175.
GeneTreeEBGT00050000026343.
HOGENOMHBG758022.
OMAEDALENP.
PhylomeDBQ49UL7.
ProtClustDBCLSK313238.

Enzyme and pathway databases

BioCycSSAP342451:SSP2409-MONOMER.

Family and domain databases

HAMAPMF_00063. CysH.
[Tree]
InterProIPR004511. PAPS/APS_Rdtase.
IPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KOK00390.
PfamPF01507. PAPS_reduct. 1 hit.
[Graphical view]
PIRSFPIRSF000857. PAPS_reductase. 1 hit.
TIGRFAMsTIGR00434. CysH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCYSH_STAS1
AccessionPrimary (citable) accession number: Q49UL7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: September 13, 2005
Last modified: January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families