Q49UH1 (ARSC2_STAS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein ArsC 2

Alternative name(s):
Arsenate reductase 2
EC=1.20.4.-
Arsenical pump modifier 2
Low molecular weight protein-tyrosine-phosphatase 2
EC=3.1.3.48

Gene names

Name:	arsC2
Ordered Locus Names:	SSPP114

Encoded on

Plasmid pSSP1

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus saprophyticus › Staphylococcus saprophyticus subsp. saprophyticus

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances By similarity. HAMAP-Rule MF_01624
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. HAMAP-Rule MF_01624 Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O. HAMAP-Rule MF_01624
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family.

Ontologies

Keywords
Biological process	Arsenical resistance
Domain	Redox-active center
Molecular function	Hydrolase Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC response to arsenic-containing substance Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	arsenate reductase (thioredoxin) activity Inferred from electronic annotation. Source: HAMAP protein tyrosine phosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 131	131	Protein ArsC 2 HAMAP-Rule MF_01624		PRO_0000162533
Sites
	Active site	10	1	Nucleophile; for reductase activity and phosphatase activity By similarity
	Active site	82	1	Nucleophile; for reductase activity By similarity
	Active site	89	1	Nucleophile; for reductase activity By similarity
Amino acid modifications
	Disulfide bond	10 ↔ 82		Redox-active; alternate By similarity
	Disulfide bond	82 ↔ 89		Redox-active; alternate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q49UH1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 1B1C91593047D803	FASTA	131	14,908
	10 20 30 40 50 60 MDKKTIYFIC TGNSCRSQMA EGWGREILGE EWNVYSAGIE THGVNPKAIE AMKEVDIDIS 70 80 90 100 110 120 NHTSDLIDNK ILRQSDLVVT LCSDADENCP VIPPNVKKEH WGFDDPAGKS WSEFQRVRDE 130 IGQKIKQFYD N

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15305 / DSM 20229.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008935 Genomic DNA. Translation: BAE19605.1.
RefSeq	YP_302550.1. NC_007351.1.
3D structure databases
ProteinModelPortal	Q49UH1.
SMR	Q49UH1. Positions 2-128.
ModBase	Search...
Protein-protein interaction databases
STRING	342451.SSPP114.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAE19605; BAE19605; SSPP114.
GeneID	3617381.
KEGG	ssp:SSPP114.
PATRIC	19626518. VBIStaSap90642_2442.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0394.
HOGENOM	HOG000273093.
KO	K03741.
OMA	QTSDMID.
ProtClustDB	PRK13530.
Family and domain databases
HAMAP	MF_01624. Arsenate_reduct.
InterPro	IPR014064. Arsenate_reductase_ArsC. IPR023485. Ptyr_pPase_SF. IPR017867. Tyr_phospatase_low_mol_wt. [Graphical view]
PANTHER	PTHR11717. PTHR11717. 1 hit.
Pfam	PF01451. LMWPc. 1 hit. [Graphical view]
SMART	SM00226. LMWPc. 1 hit. [Graphical view]
SUPFAM	SSF52788. Tyr_Pase_low_mol_wt. 1 hit.
TIGRFAMs	TIGR02691. arsC_pI258_fam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARSC2_STAS1

Accession

Primary (citable) accession number: Q49UH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	September 13, 2005
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program