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Q49SQ1

- GPR33_HUMAN

UniProt

Q49SQ1 - GPR33_HUMAN

Protein

Probable G-protein coupled receptor 33

Gene

GPR33

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Orphan receptor; could be a chemoattractant receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 33
    Gene namesi
    Name:GPR33
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:4489. GPR33.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 333333Probable G-protein coupled receptor 33PRO_0000069553Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi101 ↔ 179PROSITE-ProRule annotation
    Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ49SQ1.

    Expressioni

    Tissue specificityi

    Expressed in spleen, lung, heart, liver, kidney, pancreas, thymus, gonads and leukocytes.1 Publication

    Gene expression databases

    GenevestigatoriQ49SQ1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ49SQ1.
    SMRiQ49SQ1. Positions 25-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini54 – 6411CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini87 – 10317ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini125 – 14319CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini166 – 20944ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini231 – 24616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini269 – 28315ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini304 – 33330CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5323Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei65 – 8622Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei144 – 16522Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei210 – 23021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei247 – 26822Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei284 – 30320Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG096748.
    KOiK08382.
    PhylomeDBiQ49SQ1.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24225. PTHR24225. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q49SQ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLINSTDYL INASTLVRNS TQFLAPASKM IIALSLYISS IIGTITNGLY    50
    LWVLRFKMKQ TVNTLLFFHL ILSYFISTMI LPFMATSQLQ DNHWNFGTAL 100
    CKVFNGTLSL GMFTSVFFLS AIGLDRYLLT LHPVWSQQHR TPRWASSIVL 150
    GVWISAAALS IPYLIFRETH HDRKGKVTCQ NNYAVSTNWE SKEMQASRQW 200
    IHVACFISRF LLGFLLPFFI IIFCYERVAS KVKERSLFKS SKPFKVMMTA 250
    IISFFVCWMP YHIHQGLLLT TNQSLLLELT LILTVLTTSF NTIFSPTLYL 300
    FVGENFKKVF KKSILALFES TFSEDSSVER TQT 333
    Length:333
    Mass (Da):38,232
    Last modified:September 13, 2005 - v1
    Checksum:i72AE74EEC8FE6CB8
    GO

    Polymorphismi

    In most individuals a nonsense mutation transforms the Arg-140 into a premature stop codon. Out of 1217 individuals, 1166 had a stop codon in both alleles, 50 were heterozygous and only one (in the Philippines) had Arg-140 in both alleles. GPR33 has undergone independent pseudogenization in human, chimpanzee, orangutan, siamang and rat. This selective inactivation may be due to its interaction with a putative pathogen that could use GPR33 as a receptor for cell invasion.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY494000 Genomic DNA. Translation: AAR98754.1.
    RefSeqiNP_001184113.2. NM_001197184.2.
    UniGeneiHs.727479.

    Genome annotation databases

    GeneIDi2856.
    KEGGihsa:2856.

    Polymorphism databases

    DMDMi82592890.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY494000 Genomic DNA. Translation: AAR98754.1 .
    RefSeqi NP_001184113.2. NM_001197184.2.
    UniGenei Hs.727479.

    3D structure databases

    ProteinModelPortali Q49SQ1.
    SMRi Q49SQ1. Positions 25-312.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 82592890.

    Proteomic databases

    PRIDEi Q49SQ1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2856.
    KEGGi hsa:2856.

    Organism-specific databases

    CTDi 2856.
    GeneCardsi GC14M031953.
    HGNCi HGNC:4489. GPR33.
    MIMi 610118. gene.
    neXtProti NX_Q49SQ1.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG096748.
    KOi K08382.
    PhylomeDBi Q49SQ1.

    Miscellaneous databases

    GeneWikii GPR33.
    GenomeRNAii 2856.
    NextBioi 11265.
    PROi Q49SQ1.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q49SQ1.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24225. PTHR24225. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], POLYMORPHISM, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiGPR33_HUMAN
    AccessioniPrimary (citable) accession number: Q49SQ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3