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Q49SQ1

- GPR33_HUMAN

UniProt

Q49SQ1 - GPR33_HUMAN

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Protein

Probable G-protein coupled receptor 33

Gene
GPR33
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Orphan receptor; could be a chemoattractant receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 33
Gene namesi
Name:GPR33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:4489. GPR33.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030Extracellular Reviewed predictionAdd
BLAST
Transmembranei31 – 5323Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini54 – 6411Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei65 – 8622Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini87 – 10317Extracellular Reviewed predictionAdd
BLAST
Transmembranei104 – 12421Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini125 – 14319Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei144 – 16522Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini166 – 20944Extracellular Reviewed predictionAdd
BLAST
Transmembranei210 – 23021Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini231 – 24616Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei247 – 26822Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini269 – 28315Extracellular Reviewed predictionAdd
BLAST
Transmembranei284 – 30320Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini304 – 33330Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Probable G-protein coupled receptor 33PRO_0000069553Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Glycosylationi12 – 121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi19 – 191N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi101 ↔ 179 Reviewed prediction
Glycosylationi272 – 2721N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ49SQ1.

Expressioni

Tissue specificityi

Expressed in spleen, lung, heart, liver, kidney, pancreas, thymus, gonads and leukocytes.1 Publication

Gene expression databases

GenevestigatoriQ49SQ1.

Structurei

3D structure databases

ProteinModelPortaliQ49SQ1.
SMRiQ49SQ1. Positions 25-312.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG096748.
KOiK08382.
PhylomeDBiQ49SQ1.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49SQ1-1 [UniParc]FASTAAdd to Basket

« Hide

MDLINSTDYL INASTLVRNS TQFLAPASKM IIALSLYISS IIGTITNGLY    50
LWVLRFKMKQ TVNTLLFFHL ILSYFISTMI LPFMATSQLQ DNHWNFGTAL 100
CKVFNGTLSL GMFTSVFFLS AIGLDRYLLT LHPVWSQQHR TPRWASSIVL 150
GVWISAAALS IPYLIFRETH HDRKGKVTCQ NNYAVSTNWE SKEMQASRQW 200
IHVACFISRF LLGFLLPFFI IIFCYERVAS KVKERSLFKS SKPFKVMMTA 250
IISFFVCWMP YHIHQGLLLT TNQSLLLELT LILTVLTTSF NTIFSPTLYL 300
FVGENFKKVF KKSILALFES TFSEDSSVER TQT 333
Length:333
Mass (Da):38,232
Last modified:September 13, 2005 - v1
Checksum:i72AE74EEC8FE6CB8
GO

Polymorphismi

In most individuals a nonsense mutation transforms the Arg-140 into a premature stop codon. Out of 1217 individuals, 1166 had a stop codon in both alleles, 50 were heterozygous and only one (in the Philippines) had Arg-140 in both alleles. GPR33 has undergone independent pseudogenization in human, chimpanzee, orangutan, siamang and rat. This selective inactivation may be due to its interaction with a putative pathogen that could use GPR33 as a receptor for cell invasion.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY494000 Genomic DNA. Translation: AAR98754.1.
RefSeqiNP_001184113.2. NM_001197184.2.
UniGeneiHs.727479.

Genome annotation databases

GeneIDi2856.
KEGGihsa:2856.

Polymorphism databases

DMDMi82592890.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY494000 Genomic DNA. Translation: AAR98754.1 .
RefSeqi NP_001184113.2. NM_001197184.2.
UniGenei Hs.727479.

3D structure databases

ProteinModelPortali Q49SQ1.
SMRi Q49SQ1. Positions 25-312.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 82592890.

Proteomic databases

PRIDEi Q49SQ1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2856.
KEGGi hsa:2856.

Organism-specific databases

CTDi 2856.
GeneCardsi GC14M031953.
HGNCi HGNC:4489. GPR33.
MIMi 610118. gene.
neXtProti NX_Q49SQ1.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG096748.
KOi K08382.
PhylomeDBi Q49SQ1.

Miscellaneous databases

GeneWikii GPR33.
GenomeRNAii 2856.
NextBioi 11265.
PROi Q49SQ1.
SOURCEi Search...

Gene expression databases

Genevestigatori Q49SQ1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24225. PTHR24225. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], POLYMORPHISM, TISSUE SPECIFICITY.

Entry informationi

Entry nameiGPR33_HUMAN
AccessioniPrimary (citable) accession number: Q49SQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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