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Q49SQ1

- GPR33_HUMAN

UniProt

Q49SQ1 - GPR33_HUMAN

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Protein

Probable G-protein coupled receptor 33

Gene

GPR33

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Orphan receptor; could be a chemoattractant receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 33
Gene namesi
Name:GPR33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:4489. GPR33.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
BLAST
Transmembranei31 – 5323Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini54 – 6411CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei65 – 8622Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini87 – 10317ExtracellularSequence AnalysisAdd
BLAST
Transmembranei104 – 12421Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini125 – 14319CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei144 – 16522Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini166 – 20944ExtracellularSequence AnalysisAdd
BLAST
Transmembranei210 – 23021Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini231 – 24616CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei247 – 26822Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini269 – 28315ExtracellularSequence AnalysisAdd
BLAST
Transmembranei284 – 30320Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini304 – 33330CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Probable G-protein coupled receptor 33PRO_0000069553Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi101 ↔ 179PROSITE-ProRule annotation
Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ49SQ1.

Expressioni

Tissue specificityi

Expressed in spleen, lung, heart, liver, kidney, pancreas, thymus, gonads and leukocytes.1 Publication

Gene expression databases

GenevestigatoriQ49SQ1.

Structurei

3D structure databases

ProteinModelPortaliQ49SQ1.
SMRiQ49SQ1. Positions 25-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118990.
HOVERGENiHBG096748.
InParanoidiQ49SQ1.
KOiK08382.
PhylomeDBiQ49SQ1.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49SQ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLINSTDYL INASTLVRNS TQFLAPASKM IIALSLYISS IIGTITNGLY
60 70 80 90 100
LWVLRFKMKQ TVNTLLFFHL ILSYFISTMI LPFMATSQLQ DNHWNFGTAL
110 120 130 140 150
CKVFNGTLSL GMFTSVFFLS AIGLDRYLLT LHPVWSQQHR TPRWASSIVL
160 170 180 190 200
GVWISAAALS IPYLIFRETH HDRKGKVTCQ NNYAVSTNWE SKEMQASRQW
210 220 230 240 250
IHVACFISRF LLGFLLPFFI IIFCYERVAS KVKERSLFKS SKPFKVMMTA
260 270 280 290 300
IISFFVCWMP YHIHQGLLLT TNQSLLLELT LILTVLTTSF NTIFSPTLYL
310 320 330
FVGENFKKVF KKSILALFES TFSEDSSVER TQT
Length:333
Mass (Da):38,232
Last modified:September 13, 2005 - v1
Checksum:i72AE74EEC8FE6CB8
GO

Polymorphismi

In most individuals a nonsense mutation transforms the Arg-140 into a premature stop codon. Out of 1217 individuals, 1166 had a stop codon in both alleles, 50 were heterozygous and only one (in the Philippines) had Arg-140 in both alleles. GPR33 has undergone independent pseudogenization in human, chimpanzee, orangutan, siamang and rat. This selective inactivation may be due to its interaction with a putative pathogen that could use GPR33 as a receptor for cell invasion.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY494000 Genomic DNA. Translation: AAR98754.1.
CCDSiCCDS73628.1.
RefSeqiNP_001184113.2. NM_001197184.2.
UniGeneiHs.727479.

Genome annotation databases

EnsembliENST00000399285; ENSP00000421557; ENSG00000214943.
GeneIDi2856.
KEGGihsa:2856.

Polymorphism databases

DMDMi82592890.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY494000 Genomic DNA. Translation: AAR98754.1 .
CCDSi CCDS73628.1.
RefSeqi NP_001184113.2. NM_001197184.2.
UniGenei Hs.727479.

3D structure databases

ProteinModelPortali Q49SQ1.
SMRi Q49SQ1. Positions 25-312.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 82592890.

Proteomic databases

PRIDEi Q49SQ1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000399285 ; ENSP00000421557 ; ENSG00000214943 .
GeneIDi 2856.
KEGGi hsa:2856.

Organism-specific databases

CTDi 2856.
GeneCardsi GC14M031953.
HGNCi HGNC:4489. GPR33.
MIMi 610118. gene.
neXtProti NX_Q49SQ1.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000118990.
HOVERGENi HBG096748.
InParanoidi Q49SQ1.
KOi K08382.
PhylomeDBi Q49SQ1.

Miscellaneous databases

GeneWikii GPR33.
GenomeRNAii 2856.
NextBioi 11265.
PROi Q49SQ1.
SOURCEi Search...

Gene expression databases

Genevestigatori Q49SQ1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24225. PTHR24225. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], POLYMORPHISM, TISSUE SPECIFICITY.

Entry informationi

Entry nameiGPR33_HUMAN
AccessioniPrimary (citable) accession number: Q49SQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: September 13, 2005
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3