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Q49SQ1 (GPR33_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 33
Gene names
Name:GPR33
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor; could be a chemoattractant receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in spleen, lung, heart, liver, kidney, pancreas, thymus, gonads and leukocytes. Ref.1

Polymorphism

In most individuals a nonsense mutation transforms the Arg-140 into a premature stop codon. Out of 1217 individuals, 1166 had a stop codon in both alleles, 50 were heterozygous and only one (in the Philippines) had Arg-140 in both alleles. GPR33 has undergone independent pseudogenization in human, chimpanzee, orangutan, siamang and rat. This selective inactivation may be due to its interaction with a putative pathogen that could use GPR33 as a receptor for cell invasion.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionN-formyl peptide receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 333333Probable G-protein coupled receptor 33
PRO_0000069553

Regions

Topological domain1 – 3030Extracellular Potential
Transmembrane31 – 5323Helical; Name=1; Potential
Topological domain54 – 6411Cytoplasmic Potential
Transmembrane65 – 8622Helical; Name=2; Potential
Topological domain87 – 10317Extracellular Potential
Transmembrane104 – 12421Helical; Name=3; Potential
Topological domain125 – 14319Cytoplasmic Potential
Transmembrane144 – 16522Helical; Name=4; Potential
Topological domain166 – 20944Extracellular Potential
Transmembrane210 – 23021Helical; Name=5; Potential
Topological domain231 – 24616Cytoplasmic Potential
Transmembrane247 – 26822Helical; Name=6; Potential
Topological domain269 – 28315Extracellular Potential
Transmembrane284 – 30320Helical; Name=7; Potential
Topological domain304 – 33330Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation121N-linked (GlcNAc...) Potential
Glycosylation191N-linked (GlcNAc...) Potential
Glycosylation2721N-linked (GlcNAc...) Potential
Disulfide bond101 ↔ 179 Potential

Sequences

Sequence LengthMass (Da)Tools
Q49SQ1 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 72AE74EEC8FE6CB8

FASTA33338,232
        10         20         30         40         50         60 
MDLINSTDYL INASTLVRNS TQFLAPASKM IIALSLYISS IIGTITNGLY LWVLRFKMKQ 

        70         80         90        100        110        120 
TVNTLLFFHL ILSYFISTMI LPFMATSQLQ DNHWNFGTAL CKVFNGTLSL GMFTSVFFLS 

       130        140        150        160        170        180 
AIGLDRYLLT LHPVWSQQHR TPRWASSIVL GVWISAAALS IPYLIFRETH HDRKGKVTCQ 

       190        200        210        220        230        240 
NNYAVSTNWE SKEMQASRQW IHVACFISRF LLGFLLPFFI IIFCYERVAS KVKERSLFKS 

       250        260        270        280        290        300 
SKPFKVMMTA IISFFVCWMP YHIHQGLLLT TNQSLLLELT LILTVLTTSF NTIFSPTLYL 

       310        320        330 
FVGENFKKVF KKSILALFES TFSEDSSVER TQT 

« Hide

References

[1]"The rise and fall of the chemoattractant receptor GPR33."
Roempler H., Schulz A., Pitra C., Coop G., Przeworski M., Paeaebo S., Schoeneberg T.
J. Biol. Chem. 280:31068-31075(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], POLYMORPHISM, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY494000 Genomic DNA. Translation: AAR98754.1.
RefSeqNP_001184113.2. NM_001197184.2.
UniGeneHs.727479.

3D structure databases

ProteinModelPortalQ49SQ1.
SMRQ49SQ1. Positions 7-313.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM82592890.

Proteomic databases

PRIDEQ49SQ1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2856.
KEGGhsa:2856.

Organism-specific databases

CTD2856.
GeneCardsGC14M031953.
HGNCHGNC:4489. GPR33.
MIM610118. gene.
neXtProtNX_Q49SQ1.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG096748.
KOK08382.
PhylomeDBQ49SQ1.

Gene expression databases

GenevestigatorQ49SQ1.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000826. Formyl_pep_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24225. PTHR24225. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00526. FMETLEUPHER.
PR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR33.
GenomeRNAi2856.
NextBio11265.
PROQ49SQ1.
SOURCESearch...

Entry information

Entry nameGPR33_HUMAN
AccessionPrimary (citable) accession number: Q49SQ1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: September 13, 2005
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries