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Protein

Sodium/potassium/calcium exchanger 5

Gene

slc24a5

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cation exchanger which plays a central role in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca2+ and 1 K+ in exchange for 4 Na+.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiport, Calcium transport, Ion transport, Potassium transport, Sensory transduction, Sodium transport, Symport, Transport

Keywords - Ligandi

Calcium, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium/calcium exchanger 5
Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 5
Protein golden
Solute carrier family 24 member 5
Gene namesi
Name:slc24a5
Synonyms:nckx5
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 78ExtracellularSequence analysisAdd BLAST43
Transmembranei79 – 99Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini100 – 123CytoplasmicSequence analysisAdd BLAST24
Transmembranei124 – 144Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini145 – 148ExtracellularSequence analysis4
Transmembranei149 – 169Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini170 – 181CytoplasmicSequence analysisAdd BLAST12
Transmembranei182 – 202Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini203 – 207ExtracellularSequence analysis5
Transmembranei208 – 228Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini229 – 315CytoplasmicSequence analysisAdd BLAST87
Transmembranei316 – 336Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini337 – 350ExtracellularSequence analysisAdd BLAST14
Transmembranei351 – 371Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini372 – 381CytoplasmicSequence analysis10
Transmembranei382 – 402Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini403 – 420ExtracellularSequence analysisAdd BLAST18
Transmembranei421 – 441Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini442 – 450CytoplasmicSequence analysis9
Transmembranei451 – 471Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini472 – 482ExtracellularSequence analysisAdd BLAST11
Transmembranei483 – 503Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini504 – 513CytoplasmicSequence analysis10

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Fishes show a delayed and reduced development of pigmentation. They display a diminished number, size and density of melanosomes.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000004575536 – 513Sodium/potassium/calcium exchanger 5Add BLAST478

Proteomic databases

PaxDbiQ49SH1.

Expressioni

Tissue specificityi

Highly expressed in melanin-producing cells. Colocalizes with melanin biosynthesis marker dct.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000111901.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1307. Eukaryota.
ENOG410Y9YY. LUCA.
HOGENOMiHOG000231933.
HOVERGENiHBG054881.
InParanoidiQ49SH1.
KOiK13753.
PhylomeDBiQ49SH1.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
IPR030245. SLC24A5.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 1 hit.
PTHR10846:SF27. PTHR10846:SF27. 1 hit.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00367. TIGR00367. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q49SH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTDVFLQRR KRRDVLLSII ALLLLIFAIV HLVFCAGLSF QGSSSARVRR
60 70 80 90 100
DLENASECVQ PQSSEFPEGF FTVQERKDGG ILIYFMIIFY MLLSVSIVCD
110 120 130 140 150
EYFLPSLEVI SERLGLSQDV AGATFMAAGS SAPELVTAFL GVFVTKGDIG
160 170 180 190 200
VSTIMGSAVY NLLCICAACG LLSSAVGRLS CWPLFRDCVA YAISVAAVIA
210 220 230 240 250
IISDNRVYWY DGACLLLVYG VYVAVLCFDL RISEYVMQRF SPCCWCLKPR
260 270 280 290 300
DRDSGEQQPL VGWSDDSSLR VQRRSRNDSG IFQDDSGYSH LSLSLHGLNE
310 320 330 340 350
ISDEHKSVFS MPDHDLKRIL WVLSLPVSTL LFVSVPDCRR PFWKNFYMLT
360 370 380 390 400
FLMSAVWISA FTYVLVWMVT IVGETLGIPD TVMGMTLLAA GTSIPDTVAS
410 420 430 440 450
VMVAREGKSD MAMSNIVGSN VFDMLCLGLP WFIQTVFVDV GSPVEVNSSG
460 470 480 490 500
LVFMSCTLLL SIIFLFLAVH INGWKLDWKL GLVCLACYIL FATLSILYEL
510
GIIGNNPIRS CSD
Length:513
Mass (Da):56,782
Last modified:September 13, 2005 - v1
Checksum:i42023F56CFB37045
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192A → S in AAS76476 (PubMed:16357253).Curated1
Sequence conflicti231R → K in AAS76476 (PubMed:16357253).Curated1
Sequence conflicti445E → D in AAS76476 (PubMed:16357253).Curated1
Sequence conflicti477D → N in AAY89722 (PubMed:16357253).Curated1
Sequence conflicti512S → R in AAY89722 (PubMed:16357253).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY538713 mRNA. Translation: AAY89721.1.
AY581204 Genomic DNA. Translation: AAS76476.1.
AY682553 mRNA. Translation: AAY89722.1.
RefSeqiNP_001025451.1. NM_001030280.1.
UniGeneiDr.88204.

Genome annotation databases

GeneIDi570312.
KEGGidre:570312.

Cross-referencesi

Web resourcesi

Protein Spotlight

Skin-deep - Issue 74 of September 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY538713 mRNA. Translation: AAY89721.1.
AY581204 Genomic DNA. Translation: AAS76476.1.
AY682553 mRNA. Translation: AAY89722.1.
RefSeqiNP_001025451.1. NM_001030280.1.
UniGeneiDr.88204.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000111901.

Proteomic databases

PaxDbiQ49SH1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi570312.
KEGGidre:570312.

Organism-specific databases

CTDi283652.

Phylogenomic databases

eggNOGiKOG1307. Eukaryota.
ENOG410Y9YY. LUCA.
HOGENOMiHOG000231933.
HOVERGENiHBG054881.
InParanoidiQ49SH1.
KOiK13753.
PhylomeDBiQ49SH1.

Miscellaneous databases

PROiQ49SH1.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
IPR030245. SLC24A5.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 1 hit.
PTHR10846:SF27. PTHR10846:SF27. 1 hit.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00367. TIGR00367. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNCKX5_DANRE
AccessioniPrimary (citable) accession number: Q49SH1
Secondary accession number(s): Q49P06, Q592E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: September 13, 2005
Last modified: July 6, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.