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Q49SH1 (NCKX5_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sodium/potassium/calcium exchanger 5
Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 5
Protein golden
Solute carrier family 24 member 5
Gene names
Name:slc24a5
Synonyms:nckx5
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cation exchanger which plays a central role in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca2+ and 1 K+ in exchange for 4 Na+. Ref.1

Subcellular location

Endomembrane system; Multi-pass membrane protein. Note: Localizes to intracellular membranes, likely the melanosomes or their precursors. Ref.1

Tissue specificity

Highly expressed in melanin-producing cells. Colocalizes with melanin biosynthesis marker dct. Ref.1

Disruption phenotype

Fishes show a delayed and reduced development of pigmentation. They display a diminished number, size and density of melanosomes. Ref.1

Sequence similarities

Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3535 Potential
Chain36 – 513478Sodium/potassium/calcium exchanger 5
PRO_0000045755

Regions

Topological domain36 – 7843Extracellular Potential
Transmembrane79 – 9921Helical; Name=1; Potential
Topological domain100 – 12324Cytoplasmic Potential
Transmembrane124 – 14421Helical; Name=2; Potential
Topological domain145 – 1484Extracellular Potential
Transmembrane149 – 16921Helical; Name=3; Potential
Topological domain170 – 18112Cytoplasmic Potential
Transmembrane182 – 20221Helical; Name=4; Potential
Topological domain203 – 2075Extracellular Potential
Transmembrane208 – 22821Helical; Name=5; Potential
Topological domain229 – 31587Cytoplasmic Potential
Transmembrane316 – 33621Helical; Name=6; Potential
Topological domain337 – 35014Extracellular Potential
Transmembrane351 – 37121Helical; Name=7; Potential
Topological domain372 – 38110Cytoplasmic Potential
Transmembrane382 – 40221Helical; Name=8; Potential
Topological domain403 – 42018Extracellular Potential
Transmembrane421 – 44121Helical; Name=9; Potential
Topological domain442 – 4509Cytoplasmic Potential
Transmembrane451 – 47121Helical; Name=10; Potential
Topological domain472 – 48211Extracellular Potential
Transmembrane483 – 50321Helical; Name=11; Potential
Topological domain504 – 51310Cytoplasmic Potential

Experimental info

Sequence conflict1921A → S in AAS76476. Ref.1
Sequence conflict2311R → K in AAS76476. Ref.1
Sequence conflict4451E → D in AAS76476. Ref.1
Sequence conflict4771D → N in AAY89722. Ref.1
Sequence conflict5121S → R in AAY89722. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q49SH1 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 42023F56CFB37045

FASTA51356,782
        10         20         30         40         50         60 
MRTDVFLQRR KRRDVLLSII ALLLLIFAIV HLVFCAGLSF QGSSSARVRR DLENASECVQ 

        70         80         90        100        110        120 
PQSSEFPEGF FTVQERKDGG ILIYFMIIFY MLLSVSIVCD EYFLPSLEVI SERLGLSQDV 

       130        140        150        160        170        180 
AGATFMAAGS SAPELVTAFL GVFVTKGDIG VSTIMGSAVY NLLCICAACG LLSSAVGRLS 

       190        200        210        220        230        240 
CWPLFRDCVA YAISVAAVIA IISDNRVYWY DGACLLLVYG VYVAVLCFDL RISEYVMQRF 

       250        260        270        280        290        300 
SPCCWCLKPR DRDSGEQQPL VGWSDDSSLR VQRRSRNDSG IFQDDSGYSH LSLSLHGLNE 

       310        320        330        340        350        360 
ISDEHKSVFS MPDHDLKRIL WVLSLPVSTL LFVSVPDCRR PFWKNFYMLT FLMSAVWISA 

       370        380        390        400        410        420 
FTYVLVWMVT IVGETLGIPD TVMGMTLLAA GTSIPDTVAS VMVAREGKSD MAMSNIVGSN 

       430        440        450        460        470        480 
VFDMLCLGLP WFIQTVFVDV GSPVEVNSSG LVFMSCTLLL SIIFLFLAVH INGWKLDWKL 

       490        500        510 
GLVCLACYIL FATLSILYEL GIIGNNPIRS CSD

« Hide

References

[1]"SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans."
Lamason R.L., Mohideen M.-A.P.K., Mest J.R., Wong A.C., Norton H.L., Aros M.C., Jurynec M.J., Mao X., Humphreville V.R., Humbert J.E., Sinha S., Moore J.L., Jagadeeswaran P., Zhao W., Ning G., Makalowska I., McKeigue P.M., O'Donnell D. expand/collapse author list , Kittles R., Parra E.J., Mangini N.J., Grunwald D.J., Shriver M.D., Canfield V.A., Cheng K.C.
Science 310:1782-1786(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Skin-deep - Issue 74 of September 2006

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY538713 mRNA. Translation: AAY89721.1.
AY581204 Genomic DNA. Translation: AAS76476.1.
AY682553 mRNA. Translation: AAY89722.1.
IPIIPI00488257.
RefSeqNP_001025451.1. NM_001030280.1.
UniGeneDr.88204.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000030499.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID570312.
KEGGdre:570312.

Organism-specific databases

CTD283652.
ZFINZDB-GENE-031210-1. slc24a5.

Phylogenomic databases

eggNOGCOG0530.
HOGENOMHOG000231933.
HOVERGENHBG054881.
KOK13753.
OrthoDBEOG4H72BG.

Family and domain databases

InterProIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
[Graphical view]
PANTHERPTHR10846. PTHR10846. 1 hit.
PfamPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsTIGR00367. TIGR00367. 1 hit.
ProtoNetSearch...

Other

NextBio20890079.

Entry information

Entry nameNCKX5_DANRE
AccessionPrimary (citable) accession number: Q49SH1
Secondary accession number(s): Q49P06, Q592E6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: September 13, 2005
Last modified: April 3, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

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