SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q49SH1

- NCKX5_DANRE

UniProt

Q49SH1 - NCKX5_DANRE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Sodium/potassium/calcium exchanger 5
Gene
slc24a5, nckx5
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cation exchanger which plays a central role in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca2+ and 1 K+ in exchange for 4 Na+.1 Publication

GO - Molecular functioni

  1. antiporter activity Source: UniProtKB-KW
  2. symporter activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. calcium ion transport Source: UniProtKB-KW
  2. potassium ion transport Source: UniProtKB-KW
  3. response to stimulus Source: UniProtKB-KW
  4. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Antiport, Calcium transport, Ion transport, Potassium transport, Sensory transduction, Sodium transport, Symport, Transport

Keywords - Ligandi

Calcium, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium/calcium exchanger 5
Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 5
Protein golden
Solute carrier family 24 member 5
Gene namesi
Name:slc24a5
Synonyms:nckx5
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Subcellular locationi

Endomembrane system; Multi-pass membrane protein
Note: Localizes to intracellular membranes, likely the melanosomes or their precursors.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 7843Extracellular Reviewed prediction
Add
BLAST
Transmembranei79 – 9921Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini100 – 12324Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei124 – 14421Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini145 – 1484Extracellular Reviewed prediction
Transmembranei149 – 16921Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini170 – 18112Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei182 – 20221Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini203 – 2075Extracellular Reviewed prediction
Transmembranei208 – 22821Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini229 – 31587Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei316 – 33621Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini337 – 35014Extracellular Reviewed prediction
Add
BLAST
Transmembranei351 – 37121Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini372 – 38110Cytoplasmic Reviewed prediction
Transmembranei382 – 40221Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini403 – 42018Extracellular Reviewed prediction
Add
BLAST
Transmembranei421 – 44121Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini442 – 4509Cytoplasmic Reviewed prediction
Transmembranei451 – 47121Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini472 – 48211Extracellular Reviewed prediction
Add
BLAST
Transmembranei483 – 50321Helical; Name=11; Reviewed prediction
Add
BLAST
Topological domaini504 – 51310Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. endomembrane system Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Fishes show a delayed and reduced development of pigmentation. They display a diminished number, size and density of melanosomes.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535 Reviewed prediction
Add
BLAST
Chaini36 – 513478Sodium/potassium/calcium exchanger 5
PRO_0000045755Add
BLAST

Expressioni

Tissue specificityi

Highly expressed in melanin-producing cells. Colocalizes with melanin biosynthesis marker dct.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000030499.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0530.
HOGENOMiHOG000231933.
HOVERGENiHBG054881.
KOiK13753.
PhylomeDBiQ49SH1.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 1 hit.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00367. TIGR00367. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q49SH1-1 [UniParc]FASTAAdd to Basket

« Hide

MRTDVFLQRR KRRDVLLSII ALLLLIFAIV HLVFCAGLSF QGSSSARVRR    50
DLENASECVQ PQSSEFPEGF FTVQERKDGG ILIYFMIIFY MLLSVSIVCD 100
EYFLPSLEVI SERLGLSQDV AGATFMAAGS SAPELVTAFL GVFVTKGDIG 150
VSTIMGSAVY NLLCICAACG LLSSAVGRLS CWPLFRDCVA YAISVAAVIA 200
IISDNRVYWY DGACLLLVYG VYVAVLCFDL RISEYVMQRF SPCCWCLKPR 250
DRDSGEQQPL VGWSDDSSLR VQRRSRNDSG IFQDDSGYSH LSLSLHGLNE 300
ISDEHKSVFS MPDHDLKRIL WVLSLPVSTL LFVSVPDCRR PFWKNFYMLT 350
FLMSAVWISA FTYVLVWMVT IVGETLGIPD TVMGMTLLAA GTSIPDTVAS 400
VMVAREGKSD MAMSNIVGSN VFDMLCLGLP WFIQTVFVDV GSPVEVNSSG 450
LVFMSCTLLL SIIFLFLAVH INGWKLDWKL GLVCLACYIL FATLSILYEL 500
GIIGNNPIRS CSD 513
Length:513
Mass (Da):56,782
Last modified:September 13, 2005 - v1
Checksum:i42023F56CFB37045
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti192 – 1921A → S in AAS76476. 1 Publication
Sequence conflicti231 – 2311R → K in AAS76476. 1 Publication
Sequence conflicti445 – 4451E → D in AAS76476. 1 Publication
Sequence conflicti477 – 4771D → N in AAY89722. 1 Publication
Sequence conflicti512 – 5121S → R in AAY89722. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY538713 mRNA. Translation: AAY89721.1.
AY581204 Genomic DNA. Translation: AAS76476.1.
AY682553 mRNA. Translation: AAY89722.1.
RefSeqiNP_001025451.1. NM_001030280.1.
UniGeneiDr.88204.

Genome annotation databases

GeneIDi570312.
KEGGidre:570312.

Cross-referencesi

Web resourcesi

Protein Spotlight

Skin-deep - Issue 74 of September 2006

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY538713 mRNA. Translation: AAY89721.1 .
AY581204 Genomic DNA. Translation: AAS76476.1 .
AY682553 mRNA. Translation: AAY89722.1 .
RefSeqi NP_001025451.1. NM_001030280.1.
UniGenei Dr.88204.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000030499.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 570312.
KEGGi dre:570312.

Organism-specific databases

CTDi 283652.

Phylogenomic databases

eggNOGi COG0530.
HOGENOMi HOG000231933.
HOVERGENi HBG054881.
KOi K13753.
PhylomeDBi Q49SH1.

Miscellaneous databases

NextBioi 20890079.
PROi Q49SH1.

Family and domain databases

InterProi IPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
[Graphical view ]
PANTHERi PTHR10846. PTHR10846. 1 hit.
Pfami PF01699. Na_Ca_ex. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00367. TIGR00367. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiNCKX5_DANRE
AccessioniPrimary (citable) accession number: Q49SH1
Secondary accession number(s): Q49P06, Q592E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: September 13, 2005
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi