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Q49SH1

- NCKX5_DANRE

UniProt

Q49SH1 - NCKX5_DANRE

Protein

Sodium/potassium/calcium exchanger 5

Gene

slc24a5

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Cation exchanger which plays a central role in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca2+ and 1 K+ in exchange for 4 Na+.1 Publication

    GO - Molecular functioni

    1. antiporter activity Source: UniProtKB-KW
    2. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. calcium ion transport Source: UniProtKB-KW
    2. potassium ion transport Source: UniProtKB-KW
    3. response to stimulus Source: UniProtKB-KW
    4. sodium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Antiport, Calcium transport, Ion transport, Potassium transport, Sensory transduction, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Calcium, Potassium, Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium/calcium exchanger 5
    Alternative name(s):
    Na(+)/K(+)/Ca(2+)-exchange protein 5
    Protein golden
    Solute carrier family 24 member 5
    Gene namesi
    Name:slc24a5
    Synonyms:nckx5
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Subcellular locationi

    Endomembrane system 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Localizes to intracellular membranes, likely the melanosomes or their precursors.

    GO - Cellular componenti

    1. endomembrane system Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Fishes show a delayed and reduced development of pigmentation. They display a diminished number, size and density of melanosomes.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 513478Sodium/potassium/calcium exchanger 5PRO_0000045755Add
    BLAST

    Expressioni

    Tissue specificityi

    Highly expressed in melanin-producing cells. Colocalizes with melanin biosynthesis marker dct.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000030499.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini36 – 7843ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini100 – 12324CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini145 – 1484ExtracellularSequence Analysis
    Topological domaini170 – 18112CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini203 – 2075ExtracellularSequence Analysis
    Topological domaini229 – 31587CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini337 – 35014ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini372 – 38110CytoplasmicSequence Analysis
    Topological domaini403 – 42018ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini442 – 4509CytoplasmicSequence Analysis
    Topological domaini472 – 48211ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini504 – 51310CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei79 – 9921Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei124 – 14421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei149 – 16921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei182 – 20221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei208 – 22821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei316 – 33621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei351 – 37121Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei382 – 40221Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei421 – 44121Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei451 – 47121Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei483 – 50321Helical; Name=11Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0530.
    HOGENOMiHOG000231933.
    HOVERGENiHBG054881.
    KOiK13753.
    PhylomeDBiQ49SH1.

    Family and domain databases

    InterProiIPR004481. K/Na/Ca-exchanger.
    IPR004837. NaCa_Exmemb.
    [Graphical view]
    PANTHERiPTHR10846. PTHR10846. 1 hit.
    PfamiPF01699. Na_Ca_ex. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00367. TIGR00367. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q49SH1-1 [UniParc]FASTAAdd to Basket

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    MRTDVFLQRR KRRDVLLSII ALLLLIFAIV HLVFCAGLSF QGSSSARVRR    50
    DLENASECVQ PQSSEFPEGF FTVQERKDGG ILIYFMIIFY MLLSVSIVCD 100
    EYFLPSLEVI SERLGLSQDV AGATFMAAGS SAPELVTAFL GVFVTKGDIG 150
    VSTIMGSAVY NLLCICAACG LLSSAVGRLS CWPLFRDCVA YAISVAAVIA 200
    IISDNRVYWY DGACLLLVYG VYVAVLCFDL RISEYVMQRF SPCCWCLKPR 250
    DRDSGEQQPL VGWSDDSSLR VQRRSRNDSG IFQDDSGYSH LSLSLHGLNE 300
    ISDEHKSVFS MPDHDLKRIL WVLSLPVSTL LFVSVPDCRR PFWKNFYMLT 350
    FLMSAVWISA FTYVLVWMVT IVGETLGIPD TVMGMTLLAA GTSIPDTVAS 400
    VMVAREGKSD MAMSNIVGSN VFDMLCLGLP WFIQTVFVDV GSPVEVNSSG 450
    LVFMSCTLLL SIIFLFLAVH INGWKLDWKL GLVCLACYIL FATLSILYEL 500
    GIIGNNPIRS CSD 513
    Length:513
    Mass (Da):56,782
    Last modified:September 13, 2005 - v1
    Checksum:i42023F56CFB37045
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti192 – 1921A → S in AAS76476. (PubMed:16357253)Curated
    Sequence conflicti231 – 2311R → K in AAS76476. (PubMed:16357253)Curated
    Sequence conflicti445 – 4451E → D in AAS76476. (PubMed:16357253)Curated
    Sequence conflicti477 – 4771D → N in AAY89722. (PubMed:16357253)Curated
    Sequence conflicti512 – 5121S → R in AAY89722. (PubMed:16357253)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY538713 mRNA. Translation: AAY89721.1.
    AY581204 Genomic DNA. Translation: AAS76476.1.
    AY682553 mRNA. Translation: AAY89722.1.
    RefSeqiNP_001025451.1. NM_001030280.1.
    UniGeneiDr.88204.

    Genome annotation databases

    GeneIDi570312.
    KEGGidre:570312.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Skin-deep - Issue 74 of September 2006

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY538713 mRNA. Translation: AAY89721.1 .
    AY581204 Genomic DNA. Translation: AAS76476.1 .
    AY682553 mRNA. Translation: AAY89722.1 .
    RefSeqi NP_001025451.1. NM_001030280.1.
    UniGenei Dr.88204.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000030499.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 570312.
    KEGGi dre:570312.

    Organism-specific databases

    CTDi 283652.

    Phylogenomic databases

    eggNOGi COG0530.
    HOGENOMi HOG000231933.
    HOVERGENi HBG054881.
    KOi K13753.
    PhylomeDBi Q49SH1.

    Miscellaneous databases

    NextBioi 20890079.
    PROi Q49SH1.

    Family and domain databases

    InterProi IPR004481. K/Na/Ca-exchanger.
    IPR004837. NaCa_Exmemb.
    [Graphical view ]
    PANTHERi PTHR10846. PTHR10846. 1 hit.
    Pfami PF01699. Na_Ca_ex. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00367. TIGR00367. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiNCKX5_DANRE
    AccessioniPrimary (citable) accession number: Q49SH1
    Secondary accession number(s): Q49P06, Q592E6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3