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Q49SH1

- NCKX5_DANRE

UniProt

Q49SH1 - NCKX5_DANRE

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Protein

Sodium/potassium/calcium exchanger 5

Gene

slc24a5

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cation exchanger which plays a central role in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca2+ and 1 K+ in exchange for 4 Na+.1 Publication

GO - Molecular functioni

  1. antiporter activity Source: UniProtKB-KW
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. calcium ion transport Source: UniProtKB-KW
  2. potassium ion transport Source: UniProtKB-KW
  3. response to stimulus Source: UniProtKB-KW
  4. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Antiport, Calcium transport, Ion transport, Potassium transport, Sensory transduction, Sodium transport, Symport, Transport

Keywords - Ligandi

Calcium, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium/calcium exchanger 5
Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 5
Protein golden
Solute carrier family 24 member 5
Gene namesi
Name:slc24a5
Synonyms:nckx5
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Subcellular locationi

Endomembrane system 1 Publication; Multi-pass membrane protein 1 Publication
Note: Localizes to intracellular membranes, likely the melanosomes or their precursors.

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Fishes show a delayed and reduced development of pigmentation. They display a diminished number, size and density of melanosomes.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence AnalysisAdd
BLAST
Chaini36 – 513478Sodium/potassium/calcium exchanger 5PRO_0000045755Add
BLAST

Expressioni

Tissue specificityi

Highly expressed in melanin-producing cells. Colocalizes with melanin biosynthesis marker dct.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000030499.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 7843ExtracellularSequence AnalysisAdd
BLAST
Topological domaini100 – 12324CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini145 – 1484ExtracellularSequence Analysis
Topological domaini170 – 18112CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini203 – 2075ExtracellularSequence Analysis
Topological domaini229 – 31587CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini337 – 35014ExtracellularSequence AnalysisAdd
BLAST
Topological domaini372 – 38110CytoplasmicSequence Analysis
Topological domaini403 – 42018ExtracellularSequence AnalysisAdd
BLAST
Topological domaini442 – 4509CytoplasmicSequence Analysis
Topological domaini472 – 48211ExtracellularSequence AnalysisAdd
BLAST
Topological domaini504 – 51310CytoplasmicSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei79 – 9921Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei124 – 14421Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei149 – 16921Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei182 – 20221Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei208 – 22821Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei316 – 33621Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei351 – 37121Helical; Name=7Sequence AnalysisAdd
BLAST
Transmembranei382 – 40221Helical; Name=8Sequence AnalysisAdd
BLAST
Transmembranei421 – 44121Helical; Name=9Sequence AnalysisAdd
BLAST
Transmembranei451 – 47121Helical; Name=10Sequence AnalysisAdd
BLAST
Transmembranei483 – 50321Helical; Name=11Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0530.
HOGENOMiHOG000231933.
HOVERGENiHBG054881.
InParanoidiQ49SH1.
KOiK13753.
PhylomeDBiQ49SH1.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 1 hit.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00367. TIGR00367. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q49SH1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRTDVFLQRR KRRDVLLSII ALLLLIFAIV HLVFCAGLSF QGSSSARVRR
60 70 80 90 100
DLENASECVQ PQSSEFPEGF FTVQERKDGG ILIYFMIIFY MLLSVSIVCD
110 120 130 140 150
EYFLPSLEVI SERLGLSQDV AGATFMAAGS SAPELVTAFL GVFVTKGDIG
160 170 180 190 200
VSTIMGSAVY NLLCICAACG LLSSAVGRLS CWPLFRDCVA YAISVAAVIA
210 220 230 240 250
IISDNRVYWY DGACLLLVYG VYVAVLCFDL RISEYVMQRF SPCCWCLKPR
260 270 280 290 300
DRDSGEQQPL VGWSDDSSLR VQRRSRNDSG IFQDDSGYSH LSLSLHGLNE
310 320 330 340 350
ISDEHKSVFS MPDHDLKRIL WVLSLPVSTL LFVSVPDCRR PFWKNFYMLT
360 370 380 390 400
FLMSAVWISA FTYVLVWMVT IVGETLGIPD TVMGMTLLAA GTSIPDTVAS
410 420 430 440 450
VMVAREGKSD MAMSNIVGSN VFDMLCLGLP WFIQTVFVDV GSPVEVNSSG
460 470 480 490 500
LVFMSCTLLL SIIFLFLAVH INGWKLDWKL GLVCLACYIL FATLSILYEL
510
GIIGNNPIRS CSD
Length:513
Mass (Da):56,782
Last modified:September 13, 2005 - v1
Checksum:i42023F56CFB37045
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti192 – 1921A → S in AAS76476. (PubMed:16357253)Curated
Sequence conflicti231 – 2311R → K in AAS76476. (PubMed:16357253)Curated
Sequence conflicti445 – 4451E → D in AAS76476. (PubMed:16357253)Curated
Sequence conflicti477 – 4771D → N in AAY89722. (PubMed:16357253)Curated
Sequence conflicti512 – 5121S → R in AAY89722. (PubMed:16357253)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY538713 mRNA. Translation: AAY89721.1.
AY581204 Genomic DNA. Translation: AAS76476.1.
AY682553 mRNA. Translation: AAY89722.1.
RefSeqiNP_001025451.1. NM_001030280.1.
UniGeneiDr.88204.

Genome annotation databases

GeneIDi570312.
KEGGidre:570312.

Cross-referencesi

Web resourcesi

Protein Spotlight

Skin-deep - Issue 74 of September 2006

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY538713 mRNA. Translation: AAY89721.1 .
AY581204 Genomic DNA. Translation: AAS76476.1 .
AY682553 mRNA. Translation: AAY89722.1 .
RefSeqi NP_001025451.1. NM_001030280.1.
UniGenei Dr.88204.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000030499.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 570312.
KEGGi dre:570312.

Organism-specific databases

CTDi 283652.

Phylogenomic databases

eggNOGi COG0530.
HOGENOMi HOG000231933.
HOVERGENi HBG054881.
InParanoidi Q49SH1.
KOi K13753.
PhylomeDBi Q49SH1.

Miscellaneous databases

NextBioi 20890079.
PROi Q49SH1.

Family and domain databases

InterProi IPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
[Graphical view ]
PANTHERi PTHR10846. PTHR10846. 1 hit.
Pfami PF01699. Na_Ca_ex. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00367. TIGR00367. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiNCKX5_DANRE
AccessioniPrimary (citable) accession number: Q49SH1
Secondary accession number(s): Q49P06, Q592E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: September 13, 2005
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3