Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribonucleoside-diphosphate reductase

Gene

I4L

Organism
Vaccinia virus
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.UniRule annotation

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processDNA replicationUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductaseUniRule annotation (EC:1.17.4.1UniRule annotation)
Gene namesi
Name:I4LImported
Synonyms:VACV_BRZ_SERRO2_071Imported
ORF Names:m8089LImported, mO089LImported, VAC_DPP15_084Imported, VAC_DPP16_084Imported, VAC_DPP20_084Imported, VAC_IHDW1_075Imported, VAC_TP3_078Imported, VAC_TP5_078Imported, VACAC2_084Imported, VACV-DUKE-081Imported, VACV_069Imported, VACV_IOC_B141_099Imported, VACV_IOC_B388_099Imported, VACV_TT8_091Imported
OrganismiVaccinia virusImported
Taxonomic identifieri10245 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
Proteomesi
  • UP000171434 Componenti: Genome
  • UP000097422 Componenti: Genome
  • UP000148654 Componenti: Genome
  • UP000181484 Componenti: Genome
  • UP000181229 Componenti: Genome
  • UP000165418 Componenti: Genome
  • UP000181537 Componenti: Genome
  • UP000125606 Componenti: Genome
  • UP000098152 Componenti: Genome
  • UP000181589 Componenti: Genome
  • UP000108172 Componenti: Genome
  • UP000126037 Componenti: Genome
  • UP000148425 Componenti: Genome
  • UP000181416 Componenti: Genome
  • UP000173158 Componenti: Genome
  • UP000180962 Componenti: Genome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 92ATP-coneInterPro annotationAdd BLAST92

Sequence similaritiesi

Belongs to the ribonucleoside diphosphate reductase large chain family.UniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR005144. ATP-cone_dom.
IPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR008926. RNR_R1-su_N.
PfamiView protein in Pfam
PF03477. ATP-cone. 1 hit.
PF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
PRINTSiPR01183. RIBORDTASEM1.
SUPFAMiSSF48168. SSF48168. 1 hit.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
PROSITEiView protein in PROSITE
PS51161. ATP_CONE. 1 hit.
PS00089. RIBORED_LARGE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q49QJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVIKRNGYK ENVMFDKITS RIRKLCYGLN TDHIDPIKIA MKVIQGIYNG
60 70 80 90 100
VTTVELDTLA AEIAATCTTQ HPDYAILAAR IAVSNLHKET KKLFSEVMED
110 120 130 140 150
LFNYVNPKNG KHSPIISSIT MDIVNKYKDK LNSVIIYERD FSYNYFGFKT
160 170 180 190 200
LEKSYLLKIN NKIVERPQHM LMRVAVGIHQ WDIDSAIETY NLLSEKWFTH
210 220 230 240 250
ASPTLFNAGT SRHQMSSCFL LNMIDDSIEG IYDTLKRCAL ISKMAGGIGL
260 270 280 290 300
SISNIRASGS YISGTNGISN GIIPMLRVYN NTARYIDQGG NKRPGVMAIY
310 320 330 340 350
LEPWHSDIMA FLDLKKNTGN EEHRTRDLFI ALWIPDLFMK RVKDDGEWSL
360 370 380 390 400
MCPDECPGLD NVWGDEFERL YTLYERERRY KSIIKARVVW KAIIESQIET
410 420 430 440 450
GTPFILYKDA CNKKSNQQNL GTIKCSNLCT EIIQYADANE VAVCNLASVA
460 470 480 490 500
LNMFVIDGRF DFLKLKDVVK VIVRNLNKII DINYYPIPEA EISNKRHRPI
510 520 530 540 550
GIGVQGLADA FILLNYPFDS LEAQDLNKKI FETIYYGALE ASCELAEKEG
560 570 580 590 600
PYDTYVGSYA SNGILQYDLW NVVPSDLWNW EPLKDKIRTY GLRNSLLVAP
610 620 630 640 650
MPTASTAQIL GNNESVEPYT SNIYTRRVLS GEFQVVNPHL LRVLTERKLW
660 670 680 690 700
NDEIKNRIMA DGGSIQNTNL PEDIKRVYKT IWEIPQKTII KMAADRGAFI
710 720 730 740 750
DQSQSMNIHI ADPSYSKLTS MHFYGWSLGL KTGMYYLRTK PASAPIQFTL
760 770
DKDKIKPLVV CDSEICTSCS G
Length:771
Mass (Da):87,754
Last modified:September 13, 2005 - v1
Checksum:i6CA07F0C58EDC4F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY313847 Genomic DNA. Translation: AAR17916.1.
AY678275 Genomic DNA. Translation: AAW23481.1.
AY678277 Genomic DNA. Translation: AAW23763.1.
DQ377945 Genomic DNA. Translation: ABD57603.1.
DQ439815 Genomic DNA. Translation: ABD98543.1.
JN654981 Genomic DNA. Translation: AEY73831.1.
JN654982 Genomic DNA. Translation: AEY74071.1.
JN654985 Genomic DNA. Translation: AEY74780.1.
KC201194 Genomic DNA. Translation: AGB75794.1.
JX489135 Genomic DNA. Translation: AGJ91238.1.
KC207810 Genomic DNA. Translation: AGK06542.1.
KC207811 Genomic DNA. Translation: AGK06755.1.
KF179385 Genomic DNA. Translation: AHB35711.1.
KJ125439 Genomic DNA. Translation: AIX98990.1.
KT184690 Genomic DNA. Translation: ALF05069.1.
KT184691 Genomic DNA. Translation: ALF05320.1.
KX061501 Genomic DNA. Translation: AND73907.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY313847 Genomic DNA. Translation: AAR17916.1.
AY678275 Genomic DNA. Translation: AAW23481.1.
AY678277 Genomic DNA. Translation: AAW23763.1.
DQ377945 Genomic DNA. Translation: ABD57603.1.
DQ439815 Genomic DNA. Translation: ABD98543.1.
JN654981 Genomic DNA. Translation: AEY73831.1.
JN654982 Genomic DNA. Translation: AEY74071.1.
JN654985 Genomic DNA. Translation: AEY74780.1.
KC201194 Genomic DNA. Translation: AGB75794.1.
JX489135 Genomic DNA. Translation: AGJ91238.1.
KC207810 Genomic DNA. Translation: AGK06542.1.
KC207811 Genomic DNA. Translation: AGK06755.1.
KF179385 Genomic DNA. Translation: AHB35711.1.
KJ125439 Genomic DNA. Translation: AIX98990.1.
KT184690 Genomic DNA. Translation: ALF05069.1.
KT184691 Genomic DNA. Translation: ALF05320.1.
KX061501 Genomic DNA. Translation: AND73907.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00326.

Family and domain databases

InterProiView protein in InterPro
IPR005144. ATP-cone_dom.
IPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR008926. RNR_R1-su_N.
PfamiView protein in Pfam
PF03477. ATP-cone. 1 hit.
PF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
PRINTSiPR01183. RIBORDTASEM1.
SUPFAMiSSF48168. SSF48168. 1 hit.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
PROSITEiView protein in PROSITE
PS51161. ATP_CONE. 1 hit.
PS00089. RIBORED_LARGE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ49QJ3_9POXV
AccessioniPrimary (citable) accession number: Q49QJ3
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: May 10, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.