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Q49PX0

- Q49PX0_9POXV

UniProt

Q49PX0 - Q49PX0_9POXV

Protein
Submitted name:

Inhibitor of NFkB pathway

Gene

N1L

Organism
Vaccinia virus
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Submitted name:
    Inhibitor of NFkB pathwayImported
    Submitted name:
    N1LImported
    Submitted name:
    N1L proteinImported
    Submitted name:
    Putative virulence factorImported
    Submitted name:
    VACV-DUKE-037Imported
    Submitted name:
    VACV026Imported
    Submitted name:
    VirokineImported
    Submitted name:
    Virokine/NFkB inhibitorImported
    Gene namesi
    Name:N1LImported
    ORF Names:List025Imported, m8028LImported, mO028LImported, VAC_DPP10_037Imported, VAC_DPP11_037Imported, VAC_DPP12_037Imported, VAC_DPP13_037Imported, VAC_DPP15_037Imported, VAC_DPP16_037Imported, VAC_DPP17_037Imported, VAC_DPP19_037Imported, VAC_DPP20_037Imported, VAC_DPP21_037Imported, VAC_DPP9_037Imported, VAC_TP3_032Imported, VAC_TP5_032Imported, VACAC2_037Imported, VACCL3_037Imported, VACV-DUKE-037Imported, VACV_026Imported, VACV_TT10_033Imported, VACV_TT11_033Imported, VACV_TT12_033Imported, VACV_TT8_033Imported, VACV_TT9_033Imported, W86/88-1-025Imported
    OrganismiVaccinia virusImported
    Taxonomic identifieri10245 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2I39X-ray2.20A/B/C/D/E/F1-117[»]
    2UXEX-ray2.90A/B/C/D/E/F1-117[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ49PX0.

    Family & Domainsi

    Family and domain databases

    InterProiIPR009353. Orthopox_N1.
    IPR022819. Poxvirus.
    [Graphical view]
    PfamiPF06227. Poxvirus. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003784. VAC_N1L. 1 hit.
    ProDomiPD015763. Orthopox_N1. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Q49PX0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRTLLIRYIL WRNDNDQTYY NDDFKKLMLL DELVDDGDVC TLIKNMRMTL    50
    SDGPLLDRLN QPVNNIEDAK RMIAISAKVA RDIGERSEIR WEESFTILFR 100
    MIETYFDDLM IDLYGEK 117
    Length:117
    Mass (Da):13,962
    Last modified:April 18, 2006 - v1
    Checksum:i9050C1FECEB1B90B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF451287 Genomic DNA. Translation: AAL48257.1.
    AF455803 Genomic DNA. Translation: AAL57605.1.
    AF455804 Genomic DNA. Translation: AAL57606.1.
    AF455805 Genomic DNA. Translation: AAL57607.1.
    AF455806 Genomic DNA. Translation: AAL57608.1.
    AY313848 Genomic DNA. Translation: AAQ93123.1.
    AY313847 Genomic DNA. Translation: AAR17871.1.
    AY678275 Genomic DNA. Translation: AAW23421.1.
    AY678277 Genomic DNA. Translation: AAW23703.1.
    DQ121394 Genomic DNA. Translation: ABD52475.1.
    DQ377945 Genomic DNA. Translation: ABD57558.1.
    DQ439815 Genomic DNA. Translation: ABD98499.1.
    EF488967 Genomic DNA. Translation: ABP97444.1.
    JN654976 Genomic DNA. Translation: AEY72597.1.
    JN654977 Genomic DNA. Translation: AEY72835.1.
    JN654978 Genomic DNA. Translation: AEY73072.1.
    JN654979 Genomic DNA. Translation: AEY73312.1.
    JN654980 Genomic DNA. Translation: AEY73553.1.
    JN654981 Genomic DNA. Translation: AEY73784.1.
    JN654982 Genomic DNA. Translation: AEY74022.1.
    JN654983 Genomic DNA. Translation: AEY74262.1.
    JN654984 Genomic DNA. Translation: AEY74491.1.
    JN654985 Genomic DNA. Translation: AEY74731.1.
    JN654986 Genomic DNA. Translation: AEY74972.1.
    KC201194 Genomic DNA. Translation: AGB75748.1.
    JX489135 Genomic DNA. Translation: AGJ91179.1.
    JX489136 Genomic DNA. Translation: AGJ91452.1.
    JX489137 Genomic DNA. Translation: AGJ91723.1.
    JX489138 Genomic DNA. Translation: AGJ91994.1.
    JX489139 Genomic DNA. Translation: AGJ92269.1.
    KC207810 Genomic DNA. Translation: AGK06496.1.
    KC207811 Genomic DNA. Translation: AGK06709.1.
    KF866253 Genomic DNA. Translation: AHB23469.1.
    RefSeqiYP_232910.1. NC_006998.1.

    Genome annotation databases

    GeneIDi3707643.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF451287 Genomic DNA. Translation: AAL48257.1 .
    AF455803 Genomic DNA. Translation: AAL57605.1 .
    AF455804 Genomic DNA. Translation: AAL57606.1 .
    AF455805 Genomic DNA. Translation: AAL57607.1 .
    AF455806 Genomic DNA. Translation: AAL57608.1 .
    AY313848 Genomic DNA. Translation: AAQ93123.1 .
    AY313847 Genomic DNA. Translation: AAR17871.1 .
    AY678275 Genomic DNA. Translation: AAW23421.1 .
    AY678277 Genomic DNA. Translation: AAW23703.1 .
    DQ121394 Genomic DNA. Translation: ABD52475.1 .
    DQ377945 Genomic DNA. Translation: ABD57558.1 .
    DQ439815 Genomic DNA. Translation: ABD98499.1 .
    EF488967 Genomic DNA. Translation: ABP97444.1 .
    JN654976 Genomic DNA. Translation: AEY72597.1 .
    JN654977 Genomic DNA. Translation: AEY72835.1 .
    JN654978 Genomic DNA. Translation: AEY73072.1 .
    JN654979 Genomic DNA. Translation: AEY73312.1 .
    JN654980 Genomic DNA. Translation: AEY73553.1 .
    JN654981 Genomic DNA. Translation: AEY73784.1 .
    JN654982 Genomic DNA. Translation: AEY74022.1 .
    JN654983 Genomic DNA. Translation: AEY74262.1 .
    JN654984 Genomic DNA. Translation: AEY74491.1 .
    JN654985 Genomic DNA. Translation: AEY74731.1 .
    JN654986 Genomic DNA. Translation: AEY74972.1 .
    KC201194 Genomic DNA. Translation: AGB75748.1 .
    JX489135 Genomic DNA. Translation: AGJ91179.1 .
    JX489136 Genomic DNA. Translation: AGJ91452.1 .
    JX489137 Genomic DNA. Translation: AGJ91723.1 .
    JX489138 Genomic DNA. Translation: AGJ91994.1 .
    JX489139 Genomic DNA. Translation: AGJ92269.1 .
    KC207810 Genomic DNA. Translation: AGK06496.1 .
    KC207811 Genomic DNA. Translation: AGK06709.1 .
    KF866253 Genomic DNA. Translation: AHB23469.1 .
    RefSeqi YP_232910.1. NC_006998.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2I39 X-ray 2.20 A/B/C/D/E/F 1-117 [» ]
    2UXE X-ray 2.90 A/B/C/D/E/F 1-117 [» ]
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL1075128.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3707643.

    Miscellaneous databases

    EvolutionaryTracei Q49PX0.

    Family and domain databases

    InterProi IPR009353. Orthopox_N1.
    IPR022819. Poxvirus.
    [Graphical view ]
    Pfami PF06227. Poxvirus. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003784. VAC_N1L. 1 hit.
    ProDomi PD015763. Orthopox_N1. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. Bartlett N.W., Smith G.L.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: WRImported.
    2. Bartlett N.W., Smith G.L.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: King InstituteImported, ListerImported, USSRImported and WyethImported.
    3. "The vaccinia virus N1L protein is an intracellular homodimer that promotes virulence."
      Bartlett N., Symons J.A., Tscharke D.C., Smith G.L.
      J. Gen. Virol. 83:1965-1976(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: King InstituteImported, ListerImported, USSRImported, WRImported and WyethImported.
    4. "An attenuated LC16m8 smallpox vaccine: analysis of full-genome sequence and induction of immune protection."
      Morikawa S., Sakiyama T., Hasegawa H., Saijo M., Maeda A., Kurane I., Maeno G., Kimura J., Hirama C., Yoshida T., Asahi-Ozaki Y., Sata T., Kurata T., Kojima A.
      J. Virol. 79:11873-11891(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: LC16m8Imported and LC16mOImported.
    5. "Genomic sequence and analysis of a vaccinia virus isolate from a patient with a smallpox vaccine-related complication."
      Li G., Chen N., Feng Z., Buller R.M., Osborne J., Harms T., Damon I., Upton C., Esteban D.J.
      Virol. J. 3:88-88(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DUKEImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 3737Imported.
    7. "Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein."
      Cooray S., Bahar M.W., Abrescia N.G., McVey C.E., Bartlett N.W., Chen R.A., Stuart D.I., Grimes J.M., Smith G.L.
      J. Gen. Virol. 88:1656-1666(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS).
    8. "Genomic sequence of a clonal isolate of the vaccinia virus Lister strain employed for smallpox vaccination in France and its comparison to other orthopoxviruses."
      Garcel A., Crance J.M., Drillien R., Garin D., Favier A.L.
      J. Gen. Virol. 88:1906-1916(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ListerImported.
    9. "Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein."
      Aoyagi M., Zhai D., Jin C., Aleshin A.E., Stec B., Reed J.C., Liddington R.C.
      Protein Sci. 16:118-124(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS).
    10. "Genomic differences of Vaccinia virus clones from Dryvax smallpox vaccine: the Dryvax-like ACAM2000 and the mouse neurovirulent Clone-3."
      Osborne J.D., Da Silva M., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Upton C., Buller R.M., Chen N., Feng Z., Roper R.L., Liu J., Pougatcheva S., Chen W., Wohlhueter R.M., Esposito J.J.
      Vaccine 25:8807-8832(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: AcambisImported.
    11. "N1L gene from Vaccinia virus strain IOC."
      Reis S.A., Moussatche N., Damaso C.R.A.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: IOCImported.
    12. "Genomic analysis of the vaccinia virus strain variants found in Dryvax vaccine."
      Qin L., Upton C., Hazes B., Evans D.H.
      J. Virol. 85:13049-13060(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DryvaxImported.
    13. "Comparison of host cell gene expression in cowpox, monkeypox or vaccinia virus-infected cells reveals virus-specific regulation of immune response genes."
      Bourquain D., Dabrowski P.W., Nitsche A.
      Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: IHD-WImported.
    14. "Genomic Sequence and Virulence of Clonal Isolates of Vaccinia Virus Tiantan, the Chinese Smallpox Vaccine Strain."
      Zhang Q., Tian M., Feng Y., Zhao K., Xu J., Liu Y., Shao Y.
      PLoS ONE 8:E60557-E60557(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: TiantanImported.
    15. "Genomic analysis of vaccinia virus strain TianTan provides new insights into the evolution and evolutionary relationships between Orthopoxviruses."
      Qin L., Liang M., Evans D.H.
      Virology 0:0-0(2013)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: TianTanImported.
    16. "Genome Sequence of WAU86/88-1, a New Variant of Vaccinia Virus Lister Strain from Poland."
      Mavian C., Lopez-Bueno A., Alcami A.
      Genome Announc. 2:e01086-13(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: WAU86/88-1Imported.

    Entry informationi

    Entry nameiQ49PX0_9POXV
    AccessioniPrimary (citable) accession number: Q49PX0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 18, 2006
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3