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Q49PX0 (Q49PX0_9POXV) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

N1L EMBL AAL57605.1

N1L protein EMBL AAL48257.1

Putative virulence factor EMBL AGB75748.1

VACV-DUKE-037 EMBL ABD98499.1

VACV026 EMBL ABD57558.1

Virokine EMBL AAQ93123.1

Virokine/NFkB inhibitor EMBL AGJ91179.1
Gene names
Name:N1L EMBL AGB75748.1
ORF Names:List025 EMBL ABD52475.1, m8028L EMBL AAW23421.1, mO028L EMBL AAW23703.1, VAC_DPP10_037 EMBL AEY72835.1, VAC_DPP11_037 EMBL AEY73072.1, VAC_DPP12_037 EMBL AEY73312.1, VAC_DPP13_037 EMBL AEY73553.1, VAC_DPP15_037 EMBL AEY73784.1, VAC_DPP16_037 EMBL AEY74022.1, VAC_DPP17_037 EMBL AEY74262.1, VAC_DPP19_037 EMBL AEY74491.1, VAC_DPP20_037 EMBL AEY74731.1, VAC_DPP21_037 EMBL AEY74972.1, VAC_DPP9_037 EMBL AEY72597.1, VAC_TP3_032 EMBL AGK06496.1, VAC_TP5_032 EMBL AGK06709.1, VACAC2_037 EMBL AAR17871.1, VACCL3_037 EMBL AAQ93123.1, VACV-DUKE-037 EMBL ABD98499.1, VACV_026 EMBL ABD57558.1, VACV_TT10_033 EMBL AGJ91723.1, VACV_TT11_033 EMBL AGJ91994.1, VACV_TT12_033 EMBL AGJ92269.1, VACV_TT8_033 EMBL AGJ91179.1, VACV_TT9_033 EMBL AGJ91452.1, W86/88-1-025 EMBL AHB23469.1
OrganismVaccinia virus EMBL AAW23703.1
Taxonomic identifier10245 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus

Protein attributes

Sequence length117 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Ontologies

Keywords
   Technical term3D-structure PDB 2I39 PDB 2UXE
Gene Ontology (GO)
None. [Check GOA]

Sequences

Sequence LengthMass (Da)Tools
Q49PX0 [UniParc].

Last modified April 18, 2006. Version 1.
Checksum: 9050C1FECEB1B90B

FASTA11713,962
        10         20         30         40         50         60 
MRTLLIRYIL WRNDNDQTYY NDDFKKLMLL DELVDDGDVC TLIKNMRMTL SDGPLLDRLN 

        70         80         90        100        110 
QPVNNIEDAK RMIAISAKVA RDIGERSEIR WEESFTILFR MIETYFDDLM IDLYGEK 

« Hide

References

[1]Bartlett N.W., Smith G.L.
Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: WR EMBL AAL48257.1.
[2]Bartlett N.W., Smith G.L.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: King Institute EMBL AAL57607.1, Lister EMBL AAL57606.1, USSR EMBL AAL57608.1 and Wyeth EMBL AAL57605.1.
[3]"The vaccinia virus N1L protein is an intracellular homodimer that promotes virulence."
Bartlett N., Symons J.A., Tscharke D.C., Smith G.L.
J. Gen. Virol. 83:1965-1976(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: King Institute EMBL AAL57607.1, Lister EMBL AAL57606.1, USSR EMBL AAL57608.1, WR EMBL AAL48257.1 and Wyeth EMBL AAL57605.1.
[4]"An attenuated LC16m8 smallpox vaccine: analysis of full-genome sequence and induction of immune protection."
Morikawa S., Sakiyama T., Hasegawa H., Saijo M., Maeda A., Kurane I., Maeno G., Kimura J., Hirama C., Yoshida T., Asahi-Ozaki Y., Sata T., Kurata T., Kojima A.
J. Virol. 79:11873-11891(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: LC16m8 EMBL AAW23421.1 and LC16mO EMBL AAW23703.1.
[5]"Genomic sequence and analysis of a vaccinia virus isolate from a patient with a smallpox vaccine-related complication."
Li G., Chen N., Feng Z., Buller R.M., Osborne J., Harms T., Damon I., Upton C., Esteban D.J.
Virol. J. 3:88-88(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: DUKE EMBL ABD98499.1.
[6]Wilson R.K., Clifton S.W., Storch G., Bhonagiri V., Pepin K.H., Stanley S., Fulton L., Nash W., Maupin R., Godfrey J., Delehaunty K., Latreille P., Wang C., Kohlberg S., Newman F.K., Frey S.E., Belshe R.B.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 3737 EMBL ABD57558.1.
[7]"Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein."
Cooray S., Bahar M.W., Abrescia N.G., McVey C.E., Bartlett N.W., Chen R.A., Stuart D.I., Grimes J.M., Smith G.L.
J. Gen. Virol. 88:1656-1666(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS).
[8]"Genomic sequence of a clonal isolate of the vaccinia virus Lister strain employed for smallpox vaccination in France and its comparison to other orthopoxviruses."
Garcel A., Crance J.M., Drillien R., Garin D., Favier A.L.
J. Gen. Virol. 88:1906-1916(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Lister EMBL ABD52475.1.
[9]"Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein."
Aoyagi M., Zhai D., Jin C., Aleshin A.E., Stec B., Reed J.C., Liddington R.C.
Protein Sci. 16:118-124(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS).
[10]"Genomic differences of Vaccinia virus clones from Dryvax smallpox vaccine: the Dryvax-like ACAM2000 and the mouse neurovirulent Clone-3."
Osborne J.D., Da Silva M., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Upton C., Buller R.M., Chen N., Feng Z., Roper R.L., Liu J., Pougatcheva S., Chen W., Wohlhueter R.M., Esposito J.J.
Vaccine 25:8807-8832(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Acambis EMBL AAQ93123.1.
[11]"N1L gene from Vaccinia virus strain IOC."
Reis S.A., Moussatche N., Damaso C.R.A.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: IOC EMBL ABP97444.1.
[12]"Genomic analysis of the vaccinia virus strain variants found in Dryvax vaccine."
Qin L., Upton C., Hazes B., Evans D.H.
J. Virol. 85:13049-13060(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Dryvax EMBL AEY72597.1.
[13]"Comparison of host cell gene expression in cowpox, monkeypox or vaccinia virus-infected cells reveals virus-specific regulation of immune response genes."
Bourquain D., Dabrowski P.W., Nitsche A.
Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: IHD-W EMBL AGB75748.1.
[14]"Genomic Sequence and Virulence of Clonal Isolates of Vaccinia Virus Tiantan, the Chinese Smallpox Vaccine Strain."
Zhang Q., Tian M., Feng Y., Zhao K., Xu J., Liu Y., Shao Y.
PLoS ONE 8:E60557-E60557(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Tiantan EMBL AGJ91179.1.
[15]"Genomic analysis of vaccinia virus strain TianTan provides new insights into the evolution and evolutionary relationships between Orthopoxviruses."
Qin L., Liang M., Evans D.H.
Virology 0:0-0(2013)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: TianTan EMBL AGK06496.1.
[16]"Genome Sequence of WAU86/88-1, a New Variant of Vaccinia Virus Lister Strain from Poland."
Mavian C., Lopez-Bueno A., Alcami A.
Genome Announc. 2:e01086-13(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: WAU86/88-1 EMBL AHB23469.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF451287 Genomic DNA. Translation: AAL48257.1.
AF455803 Genomic DNA. Translation: AAL57605.1.
AF455804 Genomic DNA. Translation: AAL57606.1.
AF455805 Genomic DNA. Translation: AAL57607.1.
AF455806 Genomic DNA. Translation: AAL57608.1.
AY313848 Genomic DNA. Translation: AAQ93123.1.
AY313847 Genomic DNA. Translation: AAR17871.1.
AY678275 Genomic DNA. Translation: AAW23421.1.
AY678277 Genomic DNA. Translation: AAW23703.1.
DQ121394 Genomic DNA. Translation: ABD52475.1.
DQ377945 Genomic DNA. Translation: ABD57558.1.
DQ439815 Genomic DNA. Translation: ABD98499.1.
EF488967 Genomic DNA. Translation: ABP97444.1.
JN654976 Genomic DNA. Translation: AEY72597.1.
JN654977 Genomic DNA. Translation: AEY72835.1.
JN654978 Genomic DNA. Translation: AEY73072.1.
JN654979 Genomic DNA. Translation: AEY73312.1.
JN654980 Genomic DNA. Translation: AEY73553.1.
JN654981 Genomic DNA. Translation: AEY73784.1.
JN654982 Genomic DNA. Translation: AEY74022.1.
JN654983 Genomic DNA. Translation: AEY74262.1.
JN654984 Genomic DNA. Translation: AEY74491.1.
JN654985 Genomic DNA. Translation: AEY74731.1.
JN654986 Genomic DNA. Translation: AEY74972.1.
KC201194 Genomic DNA. Translation: AGB75748.1.
JX489135 Genomic DNA. Translation: AGJ91179.1.
JX489136 Genomic DNA. Translation: AGJ91452.1.
JX489137 Genomic DNA. Translation: AGJ91723.1.
JX489138 Genomic DNA. Translation: AGJ91994.1.
JX489139 Genomic DNA. Translation: AGJ92269.1.
KC207810 Genomic DNA. Translation: AGK06496.1.
KC207811 Genomic DNA. Translation: AGK06709.1.
KF866253 Genomic DNA. Translation: AHB23469.1.
RefSeqYP_232910.1. NC_006998.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2I39X-ray2.20A/B/C/D/E/F1-117[»]
2UXEX-ray2.90A/B/C/D/E/F1-117[»]
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL1075128.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3707643.

Family and domain databases

InterProIPR009353. Orthopox_N1.
IPR022819. Poxvirus.
[Graphical view]
PfamPF06227. Poxvirus. 1 hit.
[Graphical view]
PIRSFPIRSF003784. VAC_N1L. 1 hit.
ProDomPD015763. Orthopox_N1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

EvolutionaryTraceQ49PX0.

Entry information

Entry nameQ49PX0_9POXV
AccessionPrimary (citable) accession number: Q49PX0
Entry history
Integrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: June 11, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)