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Q49LX5

- SSR1_CANFA

UniProt

Q49LX5 - SSR1_CANFA

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Protein
Somatostatin receptor type 1
Gene
SSTR1
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins By similarity.

GO - Molecular functioni

  1. somatostatin receptor activity Source: Ensembl

GO - Biological processi

  1. glutamate receptor signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 1
Short name:
SS-1-R
Short name:
SS1-R
Short name:
SS1R
Gene namesi
Name:SSTR1
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 8

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5555Extracellular Reviewed prediction
Add
BLAST
Transmembranei56 – 8328Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini84 – 9310Cytoplasmic Reviewed prediction
Transmembranei94 – 11926Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini120 – 13011Extracellular Reviewed prediction
Add
BLAST
Transmembranei131 – 15222Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini153 – 17422Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei175 – 19521Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini196 – 21823Extracellular Reviewed prediction
Add
BLAST
Transmembranei219 – 24325Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini244 – 26926Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei270 – 29526Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini296 – 3027Extracellular Reviewed prediction
Transmembranei303 – 32624Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini327 – 39165Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Somatostatin receptor type 1
PRO_0000289598Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
Glycosylationi43 – 431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi47 – 471N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi129 ↔ 207 By similarity
Lipidationi338 – 3381S-palmitoyl cysteine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Interactioni

Subunit structurei

Interacts with SKB1 By similarity.

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000020273.

Structurei

3D structure databases

ProteinModelPortaliQ49LX5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274661.
GeneTreeiENSGT00630000089736.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
KOiK04217.
OMAiLLHHWPF.
OrthoDBiEOG7BKCVQ.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001116. Somatstn_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00587. SOMATOSTTN1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49LX5-1 [UniParc]FASTAAdd to Basket

« Hide

MFPNGTASSP SSPSPSPGSC GEGGGSRGPG AGAADGMEEP GRNASQNGTL    50
SEGQGSAILI SFIYSVVCLV GLCGNSMVIY VILRYAKMKT ATNIYILNLA 100
IADELLMLSV PFLVTSTLLR HWPFGALLCR LVLSVDAVNM FTSIYCLTVL 150
SVDRYVAVVH PIKAARYRRP TVAKVVNLGV WVLSLLVILP IVVFSRTAAN 200
SDGTVACNML MPEPAQRWLV GFVLYTFLMG FLLPVGAICL CYVLIIAKMR 250
MVALKAGWQQ RKRSERKITL MVMMVVMVFV ICWMPFYVVQ LVNVFAEQDD 300
ATVSQLSVIL GYANSCANPI LYGFLSDNFK RSFQRILCLS WMDNAAEEPV 350
DYYATALKSR AYSVEDFQPE NLESGGAVFR NGTCTSRITT L 391
Length:391
Mass (Da):42,670
Last modified:September 13, 2005 - v1
Checksum:i131F8E0152EE1725
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY702069 Genomic DNA. Translation: AAW31435.1.
RefSeqiNP_001026986.1. NM_001031816.1.
UniGeneiCfa.165.

Genome annotation databases

EnsembliENSCAFT00000021824; ENSCAFP00000020273; ENSCAFG00000013755.
GeneIDi403455.
KEGGicfa:403455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY702069 Genomic DNA. Translation: AAW31435.1 .
RefSeqi NP_001026986.1. NM_001031816.1.
UniGenei Cfa.165.

3D structure databases

ProteinModelPortali Q49LX5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000020273.

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000021824 ; ENSCAFP00000020273 ; ENSCAFG00000013755 .
GeneIDi 403455.
KEGGi cfa:403455.

Organism-specific databases

CTDi 6751.

Phylogenomic databases

eggNOGi NOG274661.
GeneTreei ENSGT00630000089736.
HOGENOMi HOG000230485.
HOVERGENi HBG106919.
KOi K04217.
OMAi LLHHWPF.
OrthoDBi EOG7BKCVQ.
TreeFami TF315737.

Miscellaneous databases

NextBioi 20816973.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001116. Somatstn_rcpt_1.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00587. SOMATOSTTN1R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of somatostatin receptors from Canis familiaris."
    Liew C.W., Richter D., Kreienkamp H.-J.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiSSR1_CANFA
AccessioniPrimary (citable) accession number: Q49LX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2005
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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