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Q49LX5

- SSR1_CANFA

UniProt

Q49LX5 - SSR1_CANFA

Protein

Somatostatin receptor type 1

Gene

SSTR1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins By similarity.By similarity

    GO - Molecular functioni

    1. somatostatin receptor activity Source: Ensembl

    GO - Biological processi

    1. glutamate receptor signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Somatostatin receptor type 1
    Short name:
    SS-1-R
    Short name:
    SS1-R
    Short name:
    SS1R
    Gene namesi
    Name:SSTR1
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 8

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 391391Somatostatin receptor type 1PRO_0000289598Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi129 ↔ 207PROSITE-ProRule annotation
    Lipidationi338 – 3381S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Interactioni

    Subunit structurei

    Interacts with SKB1.By similarity

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000020273.

    Structurei

    3D structure databases

    ProteinModelPortaliQ49LX5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5555ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini84 – 9310CytoplasmicSequence Analysis
    Topological domaini120 – 13011ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini153 – 17422CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini196 – 21823ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini244 – 26926CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini296 – 3027ExtracellularSequence Analysis
    Topological domaini327 – 39165CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei56 – 8328Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei94 – 11926Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei131 – 15222Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei175 – 19521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei219 – 24325Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei270 – 29526Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei303 – 32624Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG274661.
    GeneTreeiENSGT00630000089736.
    HOGENOMiHOG000230485.
    HOVERGENiHBG106919.
    KOiK04217.
    OMAiLLHHWPF.
    OrthoDBiEOG7BKCVQ.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001116. Somatstn_rcpt_1.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00587. SOMATOSTTN1R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q49LX5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFPNGTASSP SSPSPSPGSC GEGGGSRGPG AGAADGMEEP GRNASQNGTL    50
    SEGQGSAILI SFIYSVVCLV GLCGNSMVIY VILRYAKMKT ATNIYILNLA 100
    IADELLMLSV PFLVTSTLLR HWPFGALLCR LVLSVDAVNM FTSIYCLTVL 150
    SVDRYVAVVH PIKAARYRRP TVAKVVNLGV WVLSLLVILP IVVFSRTAAN 200
    SDGTVACNML MPEPAQRWLV GFVLYTFLMG FLLPVGAICL CYVLIIAKMR 250
    MVALKAGWQQ RKRSERKITL MVMMVVMVFV ICWMPFYVVQ LVNVFAEQDD 300
    ATVSQLSVIL GYANSCANPI LYGFLSDNFK RSFQRILCLS WMDNAAEEPV 350
    DYYATALKSR AYSVEDFQPE NLESGGAVFR NGTCTSRITT L 391
    Length:391
    Mass (Da):42,670
    Last modified:September 13, 2005 - v1
    Checksum:i131F8E0152EE1725
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY702069 Genomic DNA. Translation: AAW31435.1.
    RefSeqiNP_001026986.1. NM_001031816.1.
    UniGeneiCfa.165.

    Genome annotation databases

    EnsembliENSCAFT00000021824; ENSCAFP00000020273; ENSCAFG00000013755.
    GeneIDi403455.
    KEGGicfa:403455.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY702069 Genomic DNA. Translation: AAW31435.1 .
    RefSeqi NP_001026986.1. NM_001031816.1.
    UniGenei Cfa.165.

    3D structure databases

    ProteinModelPortali Q49LX5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000020273.

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000021824 ; ENSCAFP00000020273 ; ENSCAFG00000013755 .
    GeneIDi 403455.
    KEGGi cfa:403455.

    Organism-specific databases

    CTDi 6751.

    Phylogenomic databases

    eggNOGi NOG274661.
    GeneTreei ENSGT00630000089736.
    HOGENOMi HOG000230485.
    HOVERGENi HBG106919.
    KOi K04217.
    OMAi LLHHWPF.
    OrthoDBi EOG7BKCVQ.
    TreeFami TF315737.

    Miscellaneous databases

    NextBioi 20816973.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001116. Somatstn_rcpt_1.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00587. SOMATOSTTN1R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of somatostatin receptors from Canis familiaris."
      Liew C.W., Richter D., Kreienkamp H.-J.
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiSSR1_CANFA
    AccessioniPrimary (citable) accession number: Q49LX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3