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Q49LX5 (SSR1_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Somatostatin receptor type 1

Short name=SS-1-R
Short name=SS1-R
Short name=SS1R
Gene names
Name:SSTR1
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins By similarity.

Subunit structure

Interacts with SKB1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Somatostatin receptor type 1
PRO_0000289598

Regions

Topological domain1 – 5555Extracellular Potential
Transmembrane56 – 8328Helical; Name=1; Potential
Topological domain84 – 9310Cytoplasmic Potential
Transmembrane94 – 11926Helical; Name=2; Potential
Topological domain120 – 13011Extracellular Potential
Transmembrane131 – 15222Helical; Name=3; Potential
Topological domain153 – 17422Cytoplasmic Potential
Transmembrane175 – 19521Helical; Name=4; Potential
Topological domain196 – 21823Extracellular Potential
Transmembrane219 – 24325Helical; Name=5; Potential
Topological domain244 – 26926Cytoplasmic Potential
Transmembrane270 – 29526Helical; Name=6; Potential
Topological domain296 – 3027Extracellular Potential
Transmembrane303 – 32624Helical; Name=7; Potential
Topological domain327 – 39165Cytoplasmic Potential

Amino acid modifications

Lipidation3381S-palmitoyl cysteine Potential
Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation431N-linked (GlcNAc...) Potential
Glycosylation471N-linked (GlcNAc...) Potential
Disulfide bond129 ↔ 207 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q49LX5 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 131F8E0152EE1725

FASTA39142,670
        10         20         30         40         50         60 
MFPNGTASSP SSPSPSPGSC GEGGGSRGPG AGAADGMEEP GRNASQNGTL SEGQGSAILI 

        70         80         90        100        110        120 
SFIYSVVCLV GLCGNSMVIY VILRYAKMKT ATNIYILNLA IADELLMLSV PFLVTSTLLR 

       130        140        150        160        170        180 
HWPFGALLCR LVLSVDAVNM FTSIYCLTVL SVDRYVAVVH PIKAARYRRP TVAKVVNLGV 

       190        200        210        220        230        240 
WVLSLLVILP IVVFSRTAAN SDGTVACNML MPEPAQRWLV GFVLYTFLMG FLLPVGAICL 

       250        260        270        280        290        300 
CYVLIIAKMR MVALKAGWQQ RKRSERKITL MVMMVVMVFV ICWMPFYVVQ LVNVFAEQDD 

       310        320        330        340        350        360 
ATVSQLSVIL GYANSCANPI LYGFLSDNFK RSFQRILCLS WMDNAAEEPV DYYATALKSR 

       370        380        390 
AYSVEDFQPE NLESGGAVFR NGTCTSRITT L 

« Hide

References

[1]"Cloning of somatostatin receptors from Canis familiaris."
Liew C.W., Richter D., Kreienkamp H.-J.
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY702069 Genomic DNA. Translation: AAW31435.1.
RefSeqNP_001026986.1. NM_001031816.1.
UniGeneCfa.165.

3D structure databases

ProteinModelPortalQ49LX5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000020273.

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCAFT00000021824; ENSCAFP00000020273; ENSCAFG00000013755.
GeneID403455.
KEGGcfa:403455.

Organism-specific databases

CTD6751.

Phylogenomic databases

eggNOGNOG274661.
GeneTreeENSGT00630000089736.
HOGENOMHOG000230485.
HOVERGENHBG106919.
KOK04217.
OMALLHHWPF.
OrthoDBEOG7BKCVQ.
TreeFamTF315737.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001116. Somatstn_rcpt_1.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00587. SOMATOSTTN1R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816973.

Entry information

Entry nameSSR1_CANFA
AccessionPrimary (citable) accession number: Q49LX5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2005
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries