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Q49LX5

- SSR1_CANFA

UniProt

Q49LX5 - SSR1_CANFA

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Protein

Somatostatin receptor type 1

Gene

SSTR1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins (By similarity).By similarity

GO - Molecular functioni

  1. somatostatin receptor activity Source: Ensembl

GO - Biological processi

  1. glutamate receptor signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_246910. Peptide ligand-binding receptors.
REACT_254648. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 1
Short name:
SS-1-R
Short name:
SS1-R
Short name:
SS1R
Gene namesi
Name:SSTR1
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 8

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5555ExtracellularSequence AnalysisAdd
BLAST
Transmembranei56 – 8328Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini84 – 9310CytoplasmicSequence Analysis
Transmembranei94 – 11926Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini120 – 13011ExtracellularSequence AnalysisAdd
BLAST
Transmembranei131 – 15222Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini153 – 17422CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei175 – 19521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini196 – 21823ExtracellularSequence AnalysisAdd
BLAST
Transmembranei219 – 24325Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini244 – 26926CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei270 – 29526Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini296 – 3027ExtracellularSequence Analysis
Transmembranei303 – 32624Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini327 – 39165CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Somatostatin receptor type 1PRO_0000289598Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi129 ↔ 207PROSITE-ProRule annotation
Lipidationi338 – 3381S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Interactioni

Subunit structurei

Interacts with SKB1.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000020273.

Structurei

3D structure databases

ProteinModelPortaliQ49LX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274661.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiQ49LX5.
KOiK04217.
OMAiLLHHWPF.
OrthoDBiEOG7BKCVQ.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001116. Somatstn_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00587. SOMATOSTTN1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49LX5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFPNGTASSP SSPSPSPGSC GEGGGSRGPG AGAADGMEEP GRNASQNGTL
60 70 80 90 100
SEGQGSAILI SFIYSVVCLV GLCGNSMVIY VILRYAKMKT ATNIYILNLA
110 120 130 140 150
IADELLMLSV PFLVTSTLLR HWPFGALLCR LVLSVDAVNM FTSIYCLTVL
160 170 180 190 200
SVDRYVAVVH PIKAARYRRP TVAKVVNLGV WVLSLLVILP IVVFSRTAAN
210 220 230 240 250
SDGTVACNML MPEPAQRWLV GFVLYTFLMG FLLPVGAICL CYVLIIAKMR
260 270 280 290 300
MVALKAGWQQ RKRSERKITL MVMMVVMVFV ICWMPFYVVQ LVNVFAEQDD
310 320 330 340 350
ATVSQLSVIL GYANSCANPI LYGFLSDNFK RSFQRILCLS WMDNAAEEPV
360 370 380 390
DYYATALKSR AYSVEDFQPE NLESGGAVFR NGTCTSRITT L
Length:391
Mass (Da):42,670
Last modified:September 13, 2005 - v1
Checksum:i131F8E0152EE1725
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702069 Genomic DNA. Translation: AAW31435.1.
RefSeqiNP_001026986.1. NM_001031816.1.
UniGeneiCfa.165.

Genome annotation databases

EnsembliENSCAFT00000021824; ENSCAFP00000020273; ENSCAFG00000013755.
GeneIDi403455.
KEGGicfa:403455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702069 Genomic DNA. Translation: AAW31435.1 .
RefSeqi NP_001026986.1. NM_001031816.1.
UniGenei Cfa.165.

3D structure databases

ProteinModelPortali Q49LX5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000020273.

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000021824 ; ENSCAFP00000020273 ; ENSCAFG00000013755 .
GeneIDi 403455.
KEGGi cfa:403455.

Organism-specific databases

CTDi 6751.

Phylogenomic databases

eggNOGi NOG274661.
GeneTreei ENSGT00760000118797.
HOGENOMi HOG000230485.
HOVERGENi HBG106919.
InParanoidi Q49LX5.
KOi K04217.
OMAi LLHHWPF.
OrthoDBi EOG7BKCVQ.
TreeFami TF315737.

Enzyme and pathway databases

Reactomei REACT_246910. Peptide ligand-binding receptors.
REACT_254648. G alpha (i) signalling events.

Miscellaneous databases

NextBioi 20816973.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001116. Somatstn_rcpt_1.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00587. SOMATOSTTN1R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of somatostatin receptors from Canis familiaris."
    Liew C.W., Richter D., Kreienkamp H.-J.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiSSR1_CANFA
AccessioniPrimary (citable) accession number: Q49LX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2005
Last modified: November 26, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3