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Protein

Somatostatin receptor type 1

Gene

SSTR1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-CFA-375276. Peptide ligand-binding receptors.
R-CFA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 1
Short name:
SS-1-R
Short name:
SS1-R
Short name:
SS1R
Gene namesi
Name:SSTR1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 55ExtracellularSequence analysisAdd BLAST55
Transmembranei56 – 83Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini84 – 93CytoplasmicSequence analysis10
Transmembranei94 – 119Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini120 – 130ExtracellularSequence analysisAdd BLAST11
Transmembranei131 – 152Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini153 – 174CytoplasmicSequence analysisAdd BLAST22
Transmembranei175 – 195Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini196 – 218ExtracellularSequence analysisAdd BLAST23
Transmembranei219 – 243Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini244 – 269CytoplasmicSequence analysisAdd BLAST26
Transmembranei270 – 295Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini296 – 302ExtracellularSequence analysis7
Transmembranei303 – 326Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini327 – 391CytoplasmicSequence analysisAdd BLAST65

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002895981 – 391Somatostatin receptor type 1Add BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi43N-linked (GlcNAc...)Sequence analysis1
Glycosylationi47N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi129 ↔ 207PROSITE-ProRule annotation
Lipidationi338S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ49LX5.

Interactioni

Subunit structurei

Interacts with SKB1.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000020273.

Structurei

3D structure databases

ProteinModelPortaliQ49LX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiQ49LX5.
KOiK04217.
OMAiLLHHWPF.
OrthoDBiEOG091G0HEN.
TreeFamiTF315737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001116. Somatstn_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00587. SOMATOSTTN1R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49LX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPNGTASSP SSPSPSPGSC GEGGGSRGPG AGAADGMEEP GRNASQNGTL
60 70 80 90 100
SEGQGSAILI SFIYSVVCLV GLCGNSMVIY VILRYAKMKT ATNIYILNLA
110 120 130 140 150
IADELLMLSV PFLVTSTLLR HWPFGALLCR LVLSVDAVNM FTSIYCLTVL
160 170 180 190 200
SVDRYVAVVH PIKAARYRRP TVAKVVNLGV WVLSLLVILP IVVFSRTAAN
210 220 230 240 250
SDGTVACNML MPEPAQRWLV GFVLYTFLMG FLLPVGAICL CYVLIIAKMR
260 270 280 290 300
MVALKAGWQQ RKRSERKITL MVMMVVMVFV ICWMPFYVVQ LVNVFAEQDD
310 320 330 340 350
ATVSQLSVIL GYANSCANPI LYGFLSDNFK RSFQRILCLS WMDNAAEEPV
360 370 380 390
DYYATALKSR AYSVEDFQPE NLESGGAVFR NGTCTSRITT L
Length:391
Mass (Da):42,670
Last modified:September 13, 2005 - v1
Checksum:i131F8E0152EE1725
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702069 Genomic DNA. Translation: AAW31435.1.
RefSeqiNP_001026986.1. NM_001031816.1.
UniGeneiCfa.165.

Genome annotation databases

EnsembliENSCAFT00000021824; ENSCAFP00000020273; ENSCAFG00000013755.
GeneIDi403455.
KEGGicfa:403455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702069 Genomic DNA. Translation: AAW31435.1.
RefSeqiNP_001026986.1. NM_001031816.1.
UniGeneiCfa.165.

3D structure databases

ProteinModelPortaliQ49LX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000020273.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ49LX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000021824; ENSCAFP00000020273; ENSCAFG00000013755.
GeneIDi403455.
KEGGicfa:403455.

Organism-specific databases

CTDi6751.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiQ49LX5.
KOiK04217.
OMAiLLHHWPF.
OrthoDBiEOG091G0HEN.
TreeFamiTF315737.

Enzyme and pathway databases

ReactomeiR-CFA-375276. Peptide ligand-binding receptors.
R-CFA-418594. G alpha (i) signalling events.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001116. Somatstn_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00587. SOMATOSTTN1R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSR1_CANLF
AccessioniPrimary (citable) accession number: Q49LX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2005
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.