ID   TS1R3_FELCA             Reviewed;         865 AA.
AC   Q49KI5;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 20.
DE   RecName: Full=Taste receptor type 1 member 3;
DE            Short=Taste receptor T1R3;
DE   Flags: Precursor;
GN   Name=TAS1R3; Synonyms=T1R3;
OS   Felis silvestris catus (Cat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=16103917; DOI=10.1371/journal.pgen.0010003;
RA   Li X., Li W., Wang H., Cao J., Maehashi K., Hong L., Bachmanov A.A.,
RA   Reed D.R., Legrand-Defretin V., Beauchamp G.K., Brand J.G.;
RT   "Pseudogenization of a sweet-receptor gene accounts for cats'
RT   indifference toward sugar.";
RL   PLoS Genet. 1:27-35(2005).
CC   -!- FUNCTION: Putative taste receptor. TAS1R1/TAS1R3 responds to the
CC       umami taste stimulus (the taste of monosodium glutamate) (By
CC       similarity).
CC   -!- SUBUNIT: Forms homodimers or an heterodimer with TAS1R1.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in taste buds.
CC   -!- MISCELLANEOUS: Unlike most mammals domestic cats do not prefer and
CC       are unable to detect the sweetness of sugars. This is due to
CC       pseudogenization of the TAS1R2 gene which prevents the formation
CC       of the heterodimeric sweet taste receptor TAS1R2/TAS1R3. This
CC       molecular change was very likely an important event in the
CC       evolution of the cat's carnivorous behavior.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC       TAS1R subfamily.
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DR   EMBL; AY819786; AAX35814.1; -; mRNA.
DR   RefSeq; NP_001108019.1; -.
DR   GeneID; 100136905; -.
DR   HOVERGEN; Q49KI5; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007186; P:G-protein coupled receptor protein signalin...; IEA:UniProtKB-KW.
DR   InterPro; IPR001828; ANF_lig_bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR   InterPro; IPR017979; GPCR_3_CS.
DR   InterPro; IPR011500; GPCR_3_NCR.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07562; NCD3G; 1.
DR   PRINTS; PR00592; CASENSINGR.
DR   PRINTS; PR00248; GPCRMGR.
DR   PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; FALSE_NEG.
DR   PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; FALSE_NEG.
DR   PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; FALSE_NEG.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Signal; Transducer; Transmembrane.
FT   SIGNAL        1     24       Potential.
FT   CHAIN        25    865       Taste receptor type 1 member 3.
FT                                /FTId=PRO_0000240183.
FT   TOPO_DOM     25    573       Extracellular (Potential).
FT   TRANSMEM    574    594       1 (Potential).
FT   TOPO_DOM    595    606       Cytoplasmic (Potential).
FT   TRANSMEM    607    627       2 (Potential).
FT   TOPO_DOM    628    642       Extracellular (Potential).
FT   TRANSMEM    643    663       3 (Potential).
FT   TOPO_DOM    664    685       Cytoplasmic (Potential).
FT   TRANSMEM    686    706       4 (Potential).
FT   TOPO_DOM    707    732       Extracellular (Potential).
FT   TRANSMEM    733    753       5 (Potential).
FT   TOPO_DOM    754    765       Cytoplasmic (Potential).
FT   TRANSMEM    766    786       6 (Potential).
FT   TOPO_DOM    787    794       Extracellular (Potential).
FT   TRANSMEM    795    815       7 (Potential).
FT   TOPO_DOM    816    865       Cytoplasmic (Potential).
FT   CARBOHYD    134    134       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    267    267       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   865 AA;  94017 MW;  3B3F16D6B1DAB7E9 CRC64;
     MPGLALLGLT ALLGLTALLD HGEGATSCLS QQLRMQGDYV LGGLFPLGSA EGTGLGDGLQ
     PNATVCTRFS SLGLLWALAV KMAVEEINNG SALLPGLHLG YDLFDTCSEP MVAMKPSLVF
     MAKAGSCSIA AYCNYTQYQP RVLAVIGPHS SELALVTGKF FSFFLVPQVS YGASTDRLSN
     REIFPSFFRT VPSDQVQVAA MVELLEELGW NWVAAVGSDD EYGRQGLSLF SGLASARGIC
     IAHEGLVPLP PGSLRLGALQ GLLRQVNQSS VQVVVLFSSA HAARTLFSYS IRCKLSPKVW
     VASEAWLTSD LVMTLPGMPG VGTVLGFLQQ GAPMPEFPSY VRTRLALAAD PAFCASLDAE
     QPGLEEHVVG PRCPQCDHVT LENLSAGLLH HQTFAAYAAV YGVAQALHNT LRCNASGCPR
     REPVRPWQLL ENMYNVSFRA RGLALQFDAS GNVNVDYDLK LWVWQDPTPE LRTVGTFKGR
     LELWRSQMCW HTPGKQQPVS QCSRQCKEGQ VRRVKGFHSC CYNCVDCKAG SYQRNPDDLL
     CTQCDQDQWS PDRSTRCFAR KPMFLAWGEP AVLLLLALLA LALGLALAAL GLFLWHSDSP
     LVQASGGPRA CFGLACLGLV CLSVLLFPGQ PGPASCLAQQ PLFHLPLTGC LSTFFLQAAE
     IFVGSELPPS WAEKMRGRLR GPWAWLVVLL AMLAEAALCA WYLVAFPPEV VTDWRVLPTE
     ALVHCHVHSW ISFGLVHATN AMLAFLCFLG TFLVQSRPGR YNGARGLTFA MLAYFITWIS
     FVPLFANVHV AYQPAVQMGT ILLCALGILA TFHLPKCYLL LQRPELNTPE FFLEDNARAQ
     GSSWGQGRGE SGQKQVTPDP VTSPQ
//