ID   TS1R3_FELCA             Reviewed;         865 AA.
AC   Q49KI5;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   RecName: Full=Taste receptor type 1 member 3;
DE            Short=Taste receptor T1R3;
DE   Flags: Precursor;
GN   Name=TAS1R3; Synonyms=T1R3;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=16103917; DOI=10.1371/journal.pgen.0010003;
RA   Li X., Li W., Wang H., Cao J., Maehashi K., Hong L., Bachmanov A.A.,
RA   Reed D.R., Legrand-Defretin V., Beauchamp G.K., Brand J.G.;
RT   "Pseudogenization of a sweet-receptor gene accounts for cats' indifference
RT   toward sugar.";
RL   PLoS Genet. 1:27-35(2005).
CC   -!- FUNCTION: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami
CC       taste stimulus (the taste of monosodium glutamate) (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Forms homodimers or a heterodimer with TAS1R1.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in taste buds.
CC       {ECO:0000269|PubMed:16103917}.
CC   -!- MISCELLANEOUS: Unlike most mammals domestic cats do not prefer and are
CC       unable to detect the sweetness of sugars. This is due to
CC       pseudogenization of the TAS1R2 gene which prevents the formation of the
CC       heterodimeric sweet taste receptor TAS1R2/TAS1R3. This molecular change
CC       was very likely an important event in the evolution of the cat's
CC       carnivorous behavior.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AY819786; AAX35814.1; -; mRNA.
DR   RefSeq; NP_001108019.1; NM_001114547.1.
DR   AlphaFoldDB; Q49KI5; -.
DR   SMR; Q49KI5; -.
DR   STRING; 9685.ENSFCAP00000007059; -.
DR   GlyCosmos; Q49KI5; 2 sites, No reported glycans.
DR   PaxDb; 9685-ENSFCAP00000007059; -.
DR   GeneID; 100136905; -.
DR   KEGG; fca:100136905; -.
DR   eggNOG; KOG1056; Eukaryota.
DR   InParanoid; Q49KI5; -.
DR   OrthoDB; 4096532at2759; -.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0001582; P:detection of chemical stimulus involved in sensory perception of sweet taste; IEA:GOC.
DR   GO; GO:0050916; P:sensory perception of sweet taste; IBA:GO_Central.
DR   GO; GO:0050917; P:sensory perception of umami taste; IBA:GO_Central.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR   PANTHER; PTHR24061:SF435; TASTE RECEPTOR TYPE 1 MEMBER 3; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07562; NCD3G; 1.
DR   PRINTS; PR00592; CASENSINGR.
DR   PRINTS; PR00248; GPCRMGR.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Signal; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..865
FT                   /note="Taste receptor type 1 member 3"
FT                   /id="PRO_0000240183"
FT   TOPO_DOM        25..573
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        574..594
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        595..606
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        607..627
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        628..642
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        643..663
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        664..685
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        686..706
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        707..732
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        733..753
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        754..765
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        766..786
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        787..794
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        795..815
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        816..865
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          840..865
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        134
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        267
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   865 AA;  94017 MW;  3B3F16D6B1DAB7E9 CRC64;
     MPGLALLGLT ALLGLTALLD HGEGATSCLS QQLRMQGDYV LGGLFPLGSA EGTGLGDGLQ
     PNATVCTRFS SLGLLWALAV KMAVEEINNG SALLPGLHLG YDLFDTCSEP MVAMKPSLVF
     MAKAGSCSIA AYCNYTQYQP RVLAVIGPHS SELALVTGKF FSFFLVPQVS YGASTDRLSN
     REIFPSFFRT VPSDQVQVAA MVELLEELGW NWVAAVGSDD EYGRQGLSLF SGLASARGIC
     IAHEGLVPLP PGSLRLGALQ GLLRQVNQSS VQVVVLFSSA HAARTLFSYS IRCKLSPKVW
     VASEAWLTSD LVMTLPGMPG VGTVLGFLQQ GAPMPEFPSY VRTRLALAAD PAFCASLDAE
     QPGLEEHVVG PRCPQCDHVT LENLSAGLLH HQTFAAYAAV YGVAQALHNT LRCNASGCPR
     REPVRPWQLL ENMYNVSFRA RGLALQFDAS GNVNVDYDLK LWVWQDPTPE LRTVGTFKGR
     LELWRSQMCW HTPGKQQPVS QCSRQCKEGQ VRRVKGFHSC CYNCVDCKAG SYQRNPDDLL
     CTQCDQDQWS PDRSTRCFAR KPMFLAWGEP AVLLLLALLA LALGLALAAL GLFLWHSDSP
     LVQASGGPRA CFGLACLGLV CLSVLLFPGQ PGPASCLAQQ PLFHLPLTGC LSTFFLQAAE
     IFVGSELPPS WAEKMRGRLR GPWAWLVVLL AMLAEAALCA WYLVAFPPEV VTDWRVLPTE
     ALVHCHVHSW ISFGLVHATN AMLAFLCFLG TFLVQSRPGR YNGARGLTFA MLAYFITWIS
     FVPLFANVHV AYQPAVQMGT ILLCALGILA TFHLPKCYLL LQRPELNTPE FFLEDNARAQ
     GSSWGQGRGE SGQKQVTPDP VTSPQ
//