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Protein

Taste receptor type 1 member 3

Gene

TAS1R3

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 1 member 3
Short name:
Taste receptor T1R3
Gene namesi
Name:TAS1R3
Synonyms:T1R3
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 573549ExtracellularSequence AnalysisAdd
BLAST
Transmembranei574 – 59421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini595 – 60612CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei607 – 62721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini628 – 64215ExtracellularSequence AnalysisAdd
BLAST
Transmembranei643 – 66321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini664 – 68522CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei686 – 70621Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini707 – 73226ExtracellularSequence AnalysisAdd
BLAST
Transmembranei733 – 75321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini754 – 76512CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei766 – 78621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini787 – 7948ExtracellularSequence Analysis
Transmembranei795 – 81521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini816 – 86550CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 865841Taste receptor type 1 member 3PRO_0000240183Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Expressed in taste buds.1 Publication

Interactioni

Subunit structurei

Forms homodimers or a heterodimer with TAS1R1.

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000007059.

Structurei

3D structure databases

ProteinModelPortaliQ49KI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG303330.
HOVERGENiHBG098572.
InParanoidiQ49KI5.
KOiK04626.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q49KI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGLALLGLT ALLGLTALLD HGEGATSCLS QQLRMQGDYV LGGLFPLGSA
60 70 80 90 100
EGTGLGDGLQ PNATVCTRFS SLGLLWALAV KMAVEEINNG SALLPGLHLG
110 120 130 140 150
YDLFDTCSEP MVAMKPSLVF MAKAGSCSIA AYCNYTQYQP RVLAVIGPHS
160 170 180 190 200
SELALVTGKF FSFFLVPQVS YGASTDRLSN REIFPSFFRT VPSDQVQVAA
210 220 230 240 250
MVELLEELGW NWVAAVGSDD EYGRQGLSLF SGLASARGIC IAHEGLVPLP
260 270 280 290 300
PGSLRLGALQ GLLRQVNQSS VQVVVLFSSA HAARTLFSYS IRCKLSPKVW
310 320 330 340 350
VASEAWLTSD LVMTLPGMPG VGTVLGFLQQ GAPMPEFPSY VRTRLALAAD
360 370 380 390 400
PAFCASLDAE QPGLEEHVVG PRCPQCDHVT LENLSAGLLH HQTFAAYAAV
410 420 430 440 450
YGVAQALHNT LRCNASGCPR REPVRPWQLL ENMYNVSFRA RGLALQFDAS
460 470 480 490 500
GNVNVDYDLK LWVWQDPTPE LRTVGTFKGR LELWRSQMCW HTPGKQQPVS
510 520 530 540 550
QCSRQCKEGQ VRRVKGFHSC CYNCVDCKAG SYQRNPDDLL CTQCDQDQWS
560 570 580 590 600
PDRSTRCFAR KPMFLAWGEP AVLLLLALLA LALGLALAAL GLFLWHSDSP
610 620 630 640 650
LVQASGGPRA CFGLACLGLV CLSVLLFPGQ PGPASCLAQQ PLFHLPLTGC
660 670 680 690 700
LSTFFLQAAE IFVGSELPPS WAEKMRGRLR GPWAWLVVLL AMLAEAALCA
710 720 730 740 750
WYLVAFPPEV VTDWRVLPTE ALVHCHVHSW ISFGLVHATN AMLAFLCFLG
760 770 780 790 800
TFLVQSRPGR YNGARGLTFA MLAYFITWIS FVPLFANVHV AYQPAVQMGT
810 820 830 840 850
ILLCALGILA TFHLPKCYLL LQRPELNTPE FFLEDNARAQ GSSWGQGRGE
860
SGQKQVTPDP VTSPQ
Length:865
Mass (Da):94,017
Last modified:September 13, 2005 - v1
Checksum:i3B3F16D6B1DAB7E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY819786 mRNA. Translation: AAX35814.1.
RefSeqiNP_001108019.1. NM_001114547.1.

Genome annotation databases

GeneIDi100136905.
KEGGifca:100136905.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY819786 mRNA. Translation: AAX35814.1.
RefSeqiNP_001108019.1. NM_001114547.1.

3D structure databases

ProteinModelPortaliQ49KI5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000007059.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100136905.
KEGGifca:100136905.

Organism-specific databases

CTDi83756.

Phylogenomic databases

eggNOGiNOG303330.
HOVERGENiHBG098572.
InParanoidiQ49KI5.
KOiK04626.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Pseudogenization of a sweet-receptor gene accounts for cats' indifference toward sugar."
    Li X., Li W., Wang H., Cao J., Maehashi K., Hong L., Bachmanov A.A., Reed D.R., Legrand-Defretin V., Beauchamp G.K., Brand J.G.
    PLoS Genet. 1:27-35(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Entry informationi

Entry nameiTS1R3_FELCA
AccessioniPrimary (citable) accession number: Q49KI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: September 13, 2005
Last modified: January 7, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Unlike most mammals domestic cats do not prefer and are unable to detect the sweetness of sugars. This is due to pseudogenization of the TAS1R2 gene which prevents the formation of the heterodimeric sweet taste receptor TAS1R2/TAS1R3. This molecular change was very likely an important event in the evolution of the cat's carnivorous behavior.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.