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Reviewed, UniProtKB/Swiss-Prot Q49KI5 (TS1R3_FELCA)

Last modified June 16, 2009. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Taste receptor type 1 member 3
      Short name=Taste receptor T1R3
Gene names
Name: TAS1R3
Synonyms: T1R3
OrganismFelis silvestris catus (Cat)
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis

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Protein attributes

Sequence length865 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) By similarity.

Subunit structure

Forms homodimers or an heterodimer with TAS1R1.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in taste buds. Ref.1

Miscellaneous

Unlike most mammals domestic cats do not prefer and are unable to detect the sweetness of sugars. This is due to pseudogenization of the TAS1R2 gene which prevents the formation of the heterodimeric sweet taste receptor TAS1R2/TAS1R3. This molecular change was very likely an important event in the evolution of the cat's carnivorous behavior.

Sequence similarities

Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.

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Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainSignal
Transmembrane
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processG-protein coupled receptor protein signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 865841Taste receptor type 1 member 3
PRO_0000240183

Regions

Topological domain25 – 573549Extracellular Potential
Transmembrane574 – 594211 Potential
Topological domain595 – 60612Cytoplasmic Potential
Transmembrane607 – 627212 Potential
Topological domain628 – 64215Extracellular Potential
Transmembrane643 – 663213 Potential
Topological domain664 – 68522Cytoplasmic Potential
Transmembrane686 – 706214 Potential
Topological domain707 – 73226Extracellular Potential
Transmembrane733 – 753215 Potential
Topological domain754 – 76512Cytoplasmic Potential
Transmembrane766 – 786216 Potential
Topological domain787 – 7948Extracellular Potential
Transmembrane795 – 815217 Potential
Topological domain816 – 86550Cytoplasmic Potential

Amino acid modifications

Glycosylation1341N-linked (GlcNAc...) Potential
Glycosylation2671N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q49KI5-1 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 3B3F16D6B1DAB7E9

FASTA86594,017
        10         20         30         40         50         60 
MPGLALLGLT ALLGLTALLD HGEGATSCLS QQLRMQGDYV LGGLFPLGSA EGTGLGDGLQ 

        70         80         90        100        110        120 
PNATVCTRFS SLGLLWALAV KMAVEEINNG SALLPGLHLG YDLFDTCSEP MVAMKPSLVF 

       130        140        150        160        170        180 
MAKAGSCSIA AYCNYTQYQP RVLAVIGPHS SELALVTGKF FSFFLVPQVS YGASTDRLSN 

       190        200        210        220        230        240 
REIFPSFFRT VPSDQVQVAA MVELLEELGW NWVAAVGSDD EYGRQGLSLF SGLASARGIC 

       250        260        270        280        290        300 
IAHEGLVPLP PGSLRLGALQ GLLRQVNQSS VQVVVLFSSA HAARTLFSYS IRCKLSPKVW 

       310        320        330        340        350        360 
VASEAWLTSD LVMTLPGMPG VGTVLGFLQQ GAPMPEFPSY VRTRLALAAD PAFCASLDAE 

       370        380        390        400        410        420 
QPGLEEHVVG PRCPQCDHVT LENLSAGLLH HQTFAAYAAV YGVAQALHNT LRCNASGCPR 

       430        440        450        460        470        480 
REPVRPWQLL ENMYNVSFRA RGLALQFDAS GNVNVDYDLK LWVWQDPTPE LRTVGTFKGR 

       490        500        510        520        530        540 
LELWRSQMCW HTPGKQQPVS QCSRQCKEGQ VRRVKGFHSC CYNCVDCKAG SYQRNPDDLL 

       550        560        570        580        590        600 
CTQCDQDQWS PDRSTRCFAR KPMFLAWGEP AVLLLLALLA LALGLALAAL GLFLWHSDSP 

       610        620        630        640        650        660 
LVQASGGPRA CFGLACLGLV CLSVLLFPGQ PGPASCLAQQ PLFHLPLTGC LSTFFLQAAE 

       670        680        690        700        710        720 
IFVGSELPPS WAEKMRGRLR GPWAWLVVLL AMLAEAALCA WYLVAFPPEV VTDWRVLPTE 

       730        740        750        760        770        780 
ALVHCHVHSW ISFGLVHATN AMLAFLCFLG TFLVQSRPGR YNGARGLTFA MLAYFITWIS 

       790        800        810        820        830        840 
FVPLFANVHV AYQPAVQMGT ILLCALGILA TFHLPKCYLL LQRPELNTPE FFLEDNARAQ 

       850        860 
GSSWGQGRGE SGQKQVTPDP VTSPQ

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References

[1]"Pseudogenization of a sweet-receptor gene accounts for cats' indifference toward sugar."
Li X., Li W., Wang H., Cao J., Maehashi K., Hong L., Bachmanov A.A., Reed D.R., Legrand-Defretin V., Beauchamp G.K., Brand J.G.
PLoS Genet. 1:27-35(2005) [PubMed: 16103917] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

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Cross-references

Sequence databases

AY819786 mRNA. Translation: AAX35814.1.
RefSeqNP_001108019.1.

3D structure databases

ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Genome annotation databases

GeneID100136905.

Phylogenomic databases

HOVERGENQ49KI5.

Family and domain databases

InterProIPR001828. ANF_lig_bd_rcpt.
IPR000337. GPCR_3.
IPR017978. GPCR_3_C.
IPR000068. GPCR_3_Ca_sens_rcpt-rel.
IPR017979. GPCR_3_CS.
IPR011500. GPCR_3_NCR.
[Graphical view]
PfamPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSPR00592. CASENSINGR.
PR00248. GPCRMGR.
PROSITEPS00979. G_PROTEIN_RECEP_F3_1. False negative.
PS00980. G_PROTEIN_RECEP_F3_2. False negative.
PS00981. G_PROTEIN_RECEP_F3_3. False negative.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameTS1R3_FELCA
AccessionPrimary (citable) accession number: Q49KI5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: September 13, 2005
Last modified: June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents