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Q49KI5

- TS1R3_FELCA

UniProt

Q49KI5 - TS1R3_FELCA

Protein

Taste receptor type 1 member 3

Gene

TAS1R3

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 1 member 3
    Short name:
    Taste receptor T1R3
    Gene namesi
    Name:TAS1R3
    Synonyms:T1R3
    OrganismiFelis catus (Cat) (Felis silvestris catus)
    Taxonomic identifieri9685 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
    ProteomesiUP000011712: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 865841Taste receptor type 1 member 3PRO_0000240183Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Tissue specificityi

    Expressed in taste buds.1 Publication

    Interactioni

    Subunit structurei

    Forms homodimers or a heterodimer with TAS1R1.

    Protein-protein interaction databases

    STRINGi9685.ENSFCAP00000007059.

    Structurei

    3D structure databases

    ProteinModelPortaliQ49KI5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 573549ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini595 – 60612CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini628 – 64215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini664 – 68522CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini707 – 73226ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini754 – 76512CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini787 – 7948ExtracellularSequence Analysis
    Topological domaini816 – 86550CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei574 – 59421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei607 – 62721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei643 – 66321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei686 – 70621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei733 – 75321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei766 – 78621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei795 – 81521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG303330.
    HOVERGENiHBG098572.
    KOiK04626.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR028082. Peripla_BP_I.
    [Graphical view]
    PfamiPF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view]
    PRINTSiPR00248. GPCRMGR.
    SUPFAMiSSF53822. SSF53822. 1 hit.
    PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q49KI5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGLALLGLT ALLGLTALLD HGEGATSCLS QQLRMQGDYV LGGLFPLGSA    50
    EGTGLGDGLQ PNATVCTRFS SLGLLWALAV KMAVEEINNG SALLPGLHLG 100
    YDLFDTCSEP MVAMKPSLVF MAKAGSCSIA AYCNYTQYQP RVLAVIGPHS 150
    SELALVTGKF FSFFLVPQVS YGASTDRLSN REIFPSFFRT VPSDQVQVAA 200
    MVELLEELGW NWVAAVGSDD EYGRQGLSLF SGLASARGIC IAHEGLVPLP 250
    PGSLRLGALQ GLLRQVNQSS VQVVVLFSSA HAARTLFSYS IRCKLSPKVW 300
    VASEAWLTSD LVMTLPGMPG VGTVLGFLQQ GAPMPEFPSY VRTRLALAAD 350
    PAFCASLDAE QPGLEEHVVG PRCPQCDHVT LENLSAGLLH HQTFAAYAAV 400
    YGVAQALHNT LRCNASGCPR REPVRPWQLL ENMYNVSFRA RGLALQFDAS 450
    GNVNVDYDLK LWVWQDPTPE LRTVGTFKGR LELWRSQMCW HTPGKQQPVS 500
    QCSRQCKEGQ VRRVKGFHSC CYNCVDCKAG SYQRNPDDLL CTQCDQDQWS 550
    PDRSTRCFAR KPMFLAWGEP AVLLLLALLA LALGLALAAL GLFLWHSDSP 600
    LVQASGGPRA CFGLACLGLV CLSVLLFPGQ PGPASCLAQQ PLFHLPLTGC 650
    LSTFFLQAAE IFVGSELPPS WAEKMRGRLR GPWAWLVVLL AMLAEAALCA 700
    WYLVAFPPEV VTDWRVLPTE ALVHCHVHSW ISFGLVHATN AMLAFLCFLG 750
    TFLVQSRPGR YNGARGLTFA MLAYFITWIS FVPLFANVHV AYQPAVQMGT 800
    ILLCALGILA TFHLPKCYLL LQRPELNTPE FFLEDNARAQ GSSWGQGRGE 850
    SGQKQVTPDP VTSPQ 865
    Length:865
    Mass (Da):94,017
    Last modified:September 13, 2005 - v1
    Checksum:i3B3F16D6B1DAB7E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY819786 mRNA. Translation: AAX35814.1.
    RefSeqiNP_001108019.1. NM_001114547.1.

    Genome annotation databases

    GeneIDi100136905.
    KEGGifca:100136905.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY819786 mRNA. Translation: AAX35814.1 .
    RefSeqi NP_001108019.1. NM_001114547.1.

    3D structure databases

    ProteinModelPortali Q49KI5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9685.ENSFCAP00000007059.

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100136905.
    KEGGi fca:100136905.

    Organism-specific databases

    CTDi 83756.

    Phylogenomic databases

    eggNOGi NOG303330.
    HOVERGENi HBG098572.
    KOi K04626.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR028082. Peripla_BP_I.
    [Graphical view ]
    Pfami PF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view ]
    PRINTSi PR00248. GPCRMGR.
    SUPFAMi SSF53822. SSF53822. 1 hit.
    PROSITEi PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Pseudogenization of a sweet-receptor gene accounts for cats' indifference toward sugar."
      Li X., Li W., Wang H., Cao J., Maehashi K., Hong L., Bachmanov A.A., Reed D.R., Legrand-Defretin V., Beauchamp G.K., Brand J.G.
      PLoS Genet. 1:27-35(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiTS1R3_FELCA
    AccessioniPrimary (citable) accession number: Q49KI5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Unlike most mammals domestic cats do not prefer and are unable to detect the sweetness of sugars. This is due to pseudogenization of the TAS1R2 gene which prevents the formation of the heterodimeric sweet taste receptor TAS1R2/TAS1R3. This molecular change was very likely an important event in the evolution of the cat's carnivorous behavior.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3