Reviewed, UniProtKB/Swiss-Prot Q49KG0 (MHPF_PSEPU)

Names and origin

Protein names

Recommended name:
    Acetaldehyde dehydrogenase
    EC=1.2.1.10
Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating]

Gene names

Name:	mhpF1
Synonyms:	cbzQ

Encoded on

Plasmid pKW1

Organism

Pseudomonas putida

Taxonomic identifier

303 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the terminal reaction in meta-cleavage pathways, that is, the transformation of acetaldehyde into acetyl coenzyme A By similarity.
Catalytic activity	Acetaldehyde + CoA + NAD(+) = acetyl-CoA + NADH. HAMAP MF_01657
Pathway	Aromatic compound metabolism; 3-phenylpropionic acid degradation. HAMAP MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family. MhpF subfamily.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Plasmid
Gene Ontology (GO)
Biological process	amino acid metabolic process Inferred from electronic annotation. Source: InterPro aromatic compound catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Acetaldehyde dehydrogenase HAMAP MF_01657		PRO_0000337983

Sequences

	Sequence		Length	Mass (Da)
	Q49KG0-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 51B57FFE9CF24B43	FASTA	312	32,710
	10 20 30 40 50 60 MTTKRKVAIV GSGNVGTDLM IKILRNAEHL EMAVMVGIDP ASDGLARAGR MGVATTHEGV 70 80 90 100 110 120 AGLVKMPEFA DVDFVFDATS AGAHVKNDAL LRATKPGIRV IDLTPAAIGP YCVPVVNLEQ 130 140 150 160 170 180 HVNAENLNMV TCGGQATIPM VAAVSRVAKV HYAEIVASIA SKSAGPGTRA NIDEFTETTS 190 200 210 220 230 240 KAIEAIGGAA KGKAIIIMNP AEPPLMMRDT VYVLSEAADQ DHVEASIEEM VAAVNAYVPG 250 260 270 280 290 300 YRLKQKVQFE VIPDTAPLNI PGHGEFSGLK TSVFIEVEGA AHYLPAYAGN LDIMTSAALA 310 TAERMAQSMS QA

References

[1]	"GJ31 meta-operon." Reineke W., Kunze M. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: GJ31.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY831461 Genomic DNA. Translation: AAX50131.1.
3D structure databases
SMR	Q49KG0. Positions 1-312.
ModBase	Search...
Family and domain databases
HAMAP	MF_01657. [Tree]
InterPro	IPR003361. Acetylald_dehydrogenase. IPR015426. Acetylald_DHase_C. IPR000534. Semialdehyde_DHase_NAD-bd. [Graphical view]
PANTHER	PTHR21123. Acetylald_dh. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
TIGRFAMs	TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MHPF_PSEPU

Accession

Primary (citable) accession number: Q49KG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	September 13, 2005
Last modified:	November 25, 2008
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)