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Protein

Taste receptor type 1 member 2

Gene

TAS1R2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 1 member 2
Alternative name(s):
Sweet taste receptor T1R2
Gene namesi
Name:TAS1R2
Synonyms:T1R2
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 565546ExtracellularSequence analysisAdd
BLAST
Transmembranei566 – 58621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini587 – 60115CytoplasmicSequence analysisAdd
BLAST
Transmembranei602 – 62221Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini623 – 63412ExtracellularSequence analysisAdd
BLAST
Transmembranei635 – 65521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini656 – 68025CytoplasmicSequence analysisAdd
BLAST
Transmembranei681 – 70121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini702 – 72423ExtracellularSequence analysisAdd
BLAST
Transmembranei725 – 74521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini746 – 75712CytoplasmicSequence analysisAdd
BLAST
Transmembranei758 – 77821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini779 – 7813ExtracellularSequence analysis
Transmembranei782 – 80221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini803 – 83634CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 836817Taste receptor type 1 member 2PRO_0000285549Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence analysis
Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence analysis
Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence analysis
Glycosylationi351 – 3511N-linked (GlcNAc...)Sequence analysis
Glycosylationi427 – 4271N-linked (GlcNAc...)Sequence analysis
Glycosylationi479 – 4791N-linked (GlcNAc...)Sequence analysis
Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence analysis
Glycosylationi526 – 5261N-linked (GlcNAc...)Sequence analysis
Glycosylationi546 – 5461N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ49HI0.

Interactioni

Subunit structurei

Forms heterodimers with TAS1R3.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000022796.

Structurei

3D structure databases

ProteinModelPortaliQ49HI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
KOG2455. Eukaryota.
COG1012. LUCA.
HOGENOMiHOG000038047.
HOVERGENiHBG108601.
InParanoidiQ49HI0.
KOiK04625.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q49HI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPRAKAVCS LFILLQVLAE PAENSDFYLP GDYLLGGLFT LHANVKGTVH
60 70 80 90 100
LSFLQVPQCK KYEMKVLGYN LMQAMRFAVE EINNRSDLLP GVLLGYEIVD
110 120 130 140 150
VCYISNNVQP VLYFLAREDY SLPIQEDYSH YVPRVLAVIG PDNSESTTTV
160 170 180 190 200
AHFLSLFLLP QITYSAISDD LRDKQHFPAL LRTVAGADHQ IEAMVQLLLH
210 220 230 240 250
FNWNWIIVLV SSDDYGRYNS QLLNDRLATG DICIAFQETL PMPQPDQVVT
260 270 280 290 300
EWERQRLEAI VGKLQQSSAR VVVLFSPDLI LHNFFREVLR QNFTGAVWIA
310 320 330 340 350
SESWAIDPVL HNLTELRQTG TFLGVTTQSV PIPGFSEFRI RRTPVRLPEP
360 370 380 390 400
NRTSLEATCN QECDTCQDTT ASFNSILMLS GERVVYNVYS AVYAVAHALH
410 420 430 440 450
SLLGCTQACS KEVVYPWQLL KEIWKVNFTL LGHNVFFGQQ GDVLMPMEVI
460 470 480 490 500
QWQWDLSQNP FQSIASYYPK LRQLKAIHNI SWHTANNTIP VSMCSKDCHP
510 520 530 540 550
GQRKKPVGIH SCCFECIDCL PGTFLNRTAD EFDCQPCPSY EWSHRNDTSC
560 570 580 590 600
FKRRLAFLEW HEPSTIFVVM LTILGFLSTL AIMVIFWRHL HTPVVRSAGG
610 620 630 640 650
PMCFLMLVPL LLAYAMVPMY IGQPTFFSCL WRQTFFTLCF TICISCITVR
660 670 680 690 700
SFQIVCIFKM ARRLPRAYGY WVRCHGPYVF VASFMVLKVV IVAGNVLATT
710 720 730 740 750
ANPTARPDPD DPNIMVLSCN YRRALLFNTS LDLLLSVAGF SFAYMGKELP
760 770 780 790 800
TNYNEAKFIT LCMTFYFTSS VSLCTFMSVY DGVLVTILDL LITVLNLLGI
810 820 830
SFGYFGPKCY MVLFYPERNT QVYFSSMIQG YTMGKD
Length:836
Mass (Da):94,960
Last modified:September 13, 2005 - v1
Checksum:iCABF1E5E2152A723
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY916758 mRNA. Translation: AAX98691.1.
RefSeqiNP_001026989.1. NM_001031819.1.
UniGeneiCfa.24102.

Genome annotation databases

GeneIDi478213.
KEGGicfa:478213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY916758 mRNA. Translation: AAX98691.1.
RefSeqiNP_001026989.1. NM_001031819.1.
UniGeneiCfa.24102.

3D structure databases

ProteinModelPortaliQ49HI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000022796.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ49HI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi478213.
KEGGicfa:478213.

Organism-specific databases

CTDi80834.

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
KOG2455. Eukaryota.
COG1012. LUCA.
HOGENOMiHOG000038047.
HOVERGENiHBG108601.
InParanoidiQ49HI0.
KOiK04625.

Miscellaneous databases

NextBioi20853571.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Pseudogenization of a sweet-receptor gene accounts for cats' indifference toward sugar."
    Li X., Li W., Wang H., Cao J., Maehashi K., Hong L., Bachmanov A.A., Reed D.R., Legrand-Defretin V., Beauchamp G.K., Brand J.G.
    PLoS Genet. 1:27-35(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTS1R2_CANLF
AccessioniPrimary (citable) accession number: Q49HI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: September 13, 2005
Last modified: December 9, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.